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Joan Stephenson, PhD

JAMA. 2009;302(11):1161.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The level of a substance called vascular cell adhesion molecule 1 (VCAM-1) is a strong and independent predictor of the risk of future joint replacement surgery resulting from severe osteoarthritis of the hip and knee, report researchers from Germany, Austria, and Italy (Schett G et al. Arthritis Rheum. 2009;60[8]:2381-2389). VCAM-1 is a cell surface molecule that plays a role in promoting leukocyte adhesion and homing to sites of inflammation.

The prospective cohort study involved more than 900 randomly selected residents of Bruneck, Italy, in their 40s, 50s, 60s, and 70s. Demographic characteristics, lifestyle factors, and biochemical variables, including the level of VCAM-1 in the blood, were assessed at a baseline visit in 1990. Over the next 15 years, 60 participants had hip or knee joint replacement surgery.

Frequency of the intervention was 1.9 per 1000 person-years in the lowest VCAM-1 tertile, 4.2 for the middle tertile, . . . [Full Text of this Article]

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