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Joan Stephenson, PhD

JAMA. 2009;302(3):246.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Changes in blood glucose and insulin sensitivity are evident several years before a patient is diagnosed with type 2 diabetes, according to findings from a team of European researchers (Tabák AG et al. Lancet. doi:10.1016/S0140-6736(09)60619-X [published online ahead of print June 8, 2009]).

The prospective occupational cohort study (called Whitehall II) involved 6538 British civil servants without diabetes at baseline. During a median follow-up period of nearly 10 years, 505 cases of type 2 diabetes were diagnosed. Glucose concentrations increased and insulin sensitivity decreased as much as 3 to 6 years before diagnosis of diabetes. Starting 4 years before diagnosis, beta-cell function increased as the body attempted to compensate for increased glucose levels; it then decreased in the 3 years before diagnosis.

The researchers said "our findings suggest that people with prediabetes are already on the steep part of the glucose trajectory," the researchers noted. . . . [Full Text of this Article]

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