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	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

To the Editor: Dr Timsit and colleagues¹ reported the results of a 2-by-2 factorial design for the prevention of extraluminal catheter colonization and subsequent infections. As the authors acknowledged, the validity of such design lies in the absence of interaction between the 2 interventions. In the "Methods" section, they stated that this assumption was confirmed by testing for interaction in the Cox model. However, they did not report the power of this test to rule out any possible interaction.

The authors reported a significant increase in the semiquantitative culture count from the skin around the insertion site among patients in the 7-day dressing change interval group compared with those in the 3-day dressing change interval group. This was observed despite half of the dressings containing antiseptic-impregnated sponges.

I remain uncertain whether the use of CHGIS would reduce CRIs as much as was reported if catheter dressings were changed every 3 . . . [Full Text of this Article]

Jean-Jacques Parienti, MD
parienti-jj@chu-caen.fr
Department of Biostatistics and Clinical Research
Côte de Nacre University Hospital
Caen, France

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Chlorhexidine-Impregnated Sponges and Less Frequent Dressing Changes for Prevention of Catheter-Related Infections in Critically Ill Adults: A Randomized Controlled Trial
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