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Prevalence and Predictors

Edward O. Laumann, PhD; Anthony Paik, MA; Raymond C. Rosen, PhD

JAMA. 1999;281:537-544.

ABSTRACT
Context  While recent pharmacological advances have generated increased public interest and demand for clinical services regarding erectile dysfunction, epidemiologic data on sexual dysfunction are relatively scant for both women and men.

Objective  To assess the prevalence and risk of experiencing sexual dysfunction across various social groups and examine the determinants and health consequences of these disorders.

Design  Analysis of data from the National Health and Social Life Survey, a probability sample study of sexual behavior in a demographically representative, 1992 cohort of US adults.

Participants  A national probability sample of 1749 women and 1410 men aged 18 to 59 years at the time of the survey.

Main Outcome Measures  Risk of experiencing sexual dysfunction as well as negative concomitant outcomes.

Results  Sexual dysfunction is more prevalent for women (43%) than men (31%) and is associated with various demographic characteristics, including age and educational attainment. Women of different racial groups demonstrate different patterns of sexual dysfunction. Differences among men are not as marked but generally consistent with women. Experience of sexual dysfunction is more likely among women and men with poor physical and emotional health. Moreover, sexual dysfunction is highly associated with negative experiences in sexual relationships and overall well-being.

Conclusions  The results indicate that sexual dysfunction is an important public health concern, and emotional problems likely contribute to the experience of these problems.

INTRODUCTION

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Sexual dysfunctions are characterized by disturbances in sexual desire and in the psychophysiological changes associated with the sexual response cycle in men and women.¹ Despite increasing demand for clinical services and the potential impact of these disorders on interpersonal relationships and quality of life,^2-3 epidemiologic data are relatively scant. Based on the few available community studies, it appears that sexual dysfunctions are highly prevalent in both sexes, ranging from 10% to 52% of men and 25% to 63% of women.^4-6 Data from the Massachusetts Male Aging Study⁷ (MMAS) showed that 34.8% of men aged 40 to 70 years had moderate to complete erectile dysfunction, which was strongly related to age, health status, and emotional function. Erectile dysfunction has been described as an important public health problem by a National Institutes of Health Consensus Panel,⁸ which identified an urgent need for population-based data concerning the prevalence, determinants, and consequences of this disorder. Even less is known about the epidemiology of female sexual dysfunction.

Professional and public interest in sexual dysfunction has recently been sparked by developments in several areas. First, major advances have occurred in our understanding of the neurovascular mechanisms of sexual response in men and women.^9-11 Several new classes of drugs have been identified that offer significant therapeutic potential for the treatment of male erectile disorder,^12-14 while other agents have been proposed for sexual desire and orgasm disorders.^15-16 Availability of these drugs could increase dramatically the number of patients seeking professional help for these problems. Epidemiologic data would be of obvious value in developing appropriate service delivery and resource allocation models. Additionally, changing cultural attitudes and demographic shifts in the population have highlighted the pervasiveness of sexual concerns in all ethnic and age groups.

The present study addresses these issues by analyzing data on sexual dysfunction from the National Health and Social Life Survey (NHSLS), a study of adult sexual behavior in the United States.¹⁷ Sampling, data collection, and response analysis were all conducted under highly controlled conditions. This unique data source provides extensive information on key aspects of sexual behavior, including sexual problems and dysfunction, health and lifestyle variables, and sociocultural predictors. Prior analyses of sexual dysfunction, using NHSLS data, are limited, presenting basic prevalence rates across demographic characteristics and indicators of overall health and well-being.¹⁷(pp368-374) The present study, in contrast, uses multivariate techniques to estimate relative risk (RR) of sexual dysfunction for each demographic characteristic as well as for key risk factors.

METHODS

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Survey

The NHSLS, conducted in 1992, is a national probability sample of 1410 men and 1749 women between the ages of 18 and 59 years living in households throughout the United States. It accounts for about 97% of the population in this age range—roughly 150 million Americans. It excludes people living in group quarters such as barracks, college dormitories, and prisons, as well as those who do not know English well enough to be interviewed. The sample completion rate was greater than 79%. Checks with other high-quality samples (eg, US Census Bureau's Current Population Survey) indicated that the NHSLS succeeded in producing a truly representative sample of the population. Each respondent was surveyed in person by experienced interviewers, who matched respondents on various social attributes, for an interview averaging 90 minutes. Extensive discussion of the sampling design and evaluations of sample and data quality are found in the book by Laumann et al.¹⁷(pp35-73,549-605)

Sexual dysfunction was indexed in this study according to 7 dichotomous response items, each measuring presence of a critical symptom or problem during the past 12 months.¹⁷(p660) Response items included: (1) lacking desire for sex; (2) arousal difficulties (ie, erection problems in men, lubrication difficulties in women); (3) inability achieving climax or ejaculation; (4) anxiety about sexual performance; (5) climaxing or ejaculating too rapidly; (6) physical pain during intercourse; and (7) not finding sex pleasurable. The last 3 items were asked only of respondents who were sexually active during the prior 12-month period. Taken together, these items cover the major problem areas addressed in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition¹ classification of sexual dysfunction. Self-reports about sexual dysfunctions, especially in face-to-face interviews, are subject to underreporting biases arising from personal concerns about social stigmatization. Moreover, there may be systematic biases in underreporting related to particular attributes of the respondents. For example, older or less educated women or younger Hispanic men might be more reluctant to report sexual problems. Lack of privacy during interviews could also result in underreporting. However, analyses (not reported herein) indicate that reporting biases due to lack of privacy are negligible in NHSLS data.¹⁷(pp564-570)

A latent class analysis (LCA) was used to evaluate the syndromal clustering of individual sexual symptoms. Latent class analysis is a statistical method well suited for grouping categorical data into latent classes^18-19 and has a number of medical applications, such as evaluation of diagnostic systems^20-23 and generation of epidemiologic estimates using symptom data.^24-25 Latent class analysis tests whether a latent variable, specified as a set of mutually exclusive classes, accounts for observed covariation among manifest, categorical variables. A more detailed discussion of this method is available on request from the authors. Since diagnostic criteria for disorders of sexual dysfunction involve a complex of symptoms, we used LCA for grouping symptoms into categories. These categories, then, represent a typology of disorders for sexual dysfunction found in the US population, indicating both prevalence and types of symptoms.

We analyzed only those respondents reporting at least 1 partner in the prior 12-month period. Respondents who were sexually inactive during this period were excluded. This procedure may limit our results because excluded respondents may have avoided sex because of sexual problems. However, this procedure was necessary to ensure that each respondent answered all the symptom items since 3 items were asked only of sexually active respondents. A total of 139 men and 238 women were excluded on this basis. Excluded men were more likely to be single and have lower levels of education. We expect that this will bias our estimates of prevalence of sexual dysfunction downward since sexually inactive men generally reported higher rates of symptoms. Excluded women tended to be older and single. The exclusion of these women is likely to bias our estimates of the prevalence of sexual dysfunction upward given that these women tended to report lower rates.

Analyses performed in this study were made by use of logistic and multinomial logistic regression. For assessing the prevalence of symptoms across demographic characteristics, we performed logistic regressions for each symptom. This approach produced adjusted odds ratios (ORs), which indicate the odds that members of a given social group (eg, never married) reported the symptom relative to a reference group (eg, currently married), while controlling for other demographic characteristics. Demographic characteristics included respondent's age, marital status, educational attainment level, and race and ethnicity. Next, while controlling for these characteristics, we estimated adjusted ORs using multinomial logistic regressions for 3 sets of risk factors, each modeled separately in a nonnested manner. Risk factors associated with health and lifestyle included alcohol consumption, prior contraction of sexually transmitted diseases (STDs), presence of urinary tract symptoms, circumcision, health status, and experience of emotional or stress-related problems. Social status variables included change in income level and normative orientation, indexed by how liberal or conservative respondents' attitudes were toward sex. Risk factors associated with sexual experience included the number of lifetime sex partners, frequency of sex, how often respondents think about sex, frequency of masturbation, same sex contact, and experience in potentially traumatic events such as adult-child contact, forced sexual contact, sexual harassment, and abortion. Finally, we conducted a set of logistic regressions that used the categories of sexual dysfunction as predictor variables. These models measured the association between experience of dysfunction categories and quality-of-life concomitants, which included being satisfied personally and in relationships. We stress that concomitant outcomes cannot be causally linked as an outcome of sexual dysfunction. Latent class analyses were performed using maximum likelihood latent structure analysis.²⁶ All logistic regressions used STATA version 5.0.²⁷ Information regarding variable construction, LCA methods, and data quality are available from the authors.

RESULTS

Jump to Section  • Top  • Introduction  • Methods  • Results  • Comment  • Conclusion  • Author information  • References

Prevalence of Sexual Problems

Use of NHSLS data allows for calculating national prevalence estimates of sexual problems for adult women and men. While NHSLS data on critical symptoms do not connote a clinical definition of sexual dysfunction, their prevalence does provide important information about their extent and differential distribution among the US population. Table 1 and Table 2 analyze the prevalencing sexual problems across selected demographic characteristics. For women, the prevalence of sexual problems tends to decrease with increasing age except for those who report trouble lubricating. Increasing age for men is positively associated with experience of erection problems and lacking desire for sex. The oldest cohort of men (ages 50-59 years) is more than 3 times as likely to experience erection problems (95% confidence interval [CI], 1.8-7.0) and to report low sexual desire (95% CI, 1.6-5.4) in comparison to men aged 18 to 29 years. The prevalence of sexual problems also varies significantly across marital status. Premarital and postmarital (divorced, widowed, or separated) statuses are associated with elevated risk of experiencing sexual problems. Nonmarried women are roughly 1 times more likely to have climax problems (95% CI, 1.0-2.1 and 1.2-2.3, respectively) and sexual anxiety (95% CI, 1.0-2.4 and 1.1-2.4, respectively) than married women. Similarly, nonmarried men report significantly higher rates for most symptoms of sexual dysfunction than married men. Thus, married women and men are clearly at lower risk of experiencing sexual symptoms than their nonmarried counterparts.

View this table: [in this window] [in a new window] Table 1. Prevalence of Dysfunction Items by Demographic Characteristics (Women)*

View this table: [in this window] [in a new window] Table 2. Prevalence of Dysfunction Items by Demographic Characteristics (Men)*

High educational attainment is negatively associated with experience of sexual problems for both sexes. These differences are especially marked between women who do not have high school diplomas and those who have college degrees. Controlling for other demographic characteristics, women who have graduated from college are roughly half as likely to experience low sexual desire (95% CI, 0.3-0.8), problems achieving orgasm (95% CI, 0.3-0.7), sexual pain (95% CI, 0.3-1.0), and sexual anxiety (95% CI, 0.3-1.0) as women who have not graduated from high school. Male college graduates are only two thirds (95% CI, 0.4-1.0) as likely to report climaxing too early and half as likely to report nonpleasurable sex (95% CI, 0.2-0.9) and sexual anxiety (95% CI, 0.3-0.8) than men who do not have high school diplomas. Overall, women and men with lower educational attainment report less pleasurable sexual experience and raised levels of sexual anxiety.

The association between race and ethnicity and sexual problems is more variable. Black women tend to have higher rates of low sexual desire and experience less pleasure compared with white women, who are more likely to have sexual pain than black women. Hispanic women, in contrast, consistently report lower rates of sexual problems. Differences between men are not as marked but are generally consistent with what women experience. Indeed, although the effects of race and ethnicity are fairly modest among both sexes, blacks appear more likely to have sexual problems while Hispanics are less likely to have sexual problems, across the categories of sexual dysfunction.

Latent Class Analysis

The results of LCA allow for analyzing risk factors and quality-of-life concomitants in relation to categories of sexual dysfunction, rather than individual symptoms. Analyses presented in Table 3, Table 4 , and Table 5 use the results of LCA instead of individual symptoms. These results indicate that the clustering of symptoms according to syndrome can be represented by 4 categories for women as well as for men. Latent class analysis also estimates the size of each class as a proportion of the total sample, a result corresponding to prevalence of categories of sexual dysfunction in the US population. Finally, LCA identifies each class's symptoms, indicating the likelihood that respondents in that class will exhibit a given symptom, thus providing researchers with information about what elements characterize each category. Although not equivalent to clinical diagnosis, this approach offers a statistical representation of sexual dysfunction.

View this table: [in this window] [in a new window] Table 3. Latent Classes of Sexual Dysfunction by Risk Factors (Women)*

View this table: [in this window] [in a new window] Table 4. Latent Classes of Sexual Dysfunction by Risk Factors (Men)*

View this table: [in this window] [in a new window] Table 5. Quality-of-Life Concomitants by Latent Classes of Sexual Dysfunction*

For women, the 4 categories identified by LCA roughly correspond to major disorders of sexual dysfunction as outlined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition.¹ These include an unaffected group (58% prevalence), a low sexual desire category (22% prevalence), a category for arousal problems (14% prevalence), and a group with sexual pain (7% prevalence). Similarly, a large proportion of men (70% prevalence) constitutes an unaffected population. The remaining categories consist of premature ejaculation (21% prevalence), erectile dysfunction (5% prevalence), and low sexual desire (5% prevalence). Overall, the results of LCA show that the total prevalence of sexual dysfunction is higher for women than men (43% vs 31%).

Risk Factors

Table 3 and Table 4 present multinomial logistic regressions on categories of sexual dysfunction. Adjusted ORs indicate the relative risk of experiencing a given category of sexual dysfunction vs reporting no problems for each risk factor, while controlling for other characteristics. With regard to health and lifestyle risk factors, those who experience emotional or stress-related problems are more likely to experience sexual dysfunctions defined in each of the categories. In contrast, health problems affect women and men differently. Men with poor health have elevated risk for all categories of sexual dysfunction, whereas this factor is only associated with sexual pain for women. The presence of urinary tract symptoms appears to impact sexual function only (eg, arousal and pain disorders for women or erectile dysfunction for men). Finally, having had an STD, moderate to high alcohol consumption, and circumcision generally do not result in increased odds of experiencing sexual dysfunction.

Social status variables, which measure an individual's socioeconomic and normative position relative to other persons, assess how sociocultural position affects sexual function. Deterioration in economic position, indexed by falling household income, is generally associated with a modest increase in risk for all categories of sexual dysfunction for women but only erectile dysfunction for men. Normative orientation does not appear to have any impact on sexual dysfunction for women; men with liberal attitudes about sex, in contrast, are approximately 1 times more likely to experience premature ejaculation (95% CI, 1.2-2.5).

Finally, various aspects of sexual experience result in an increased risk of sexual dysfunction. Sexual history, indicated by having more than 5 lifetime partners and by masturbation practices, does not increase relative risk for either women or men. Women with low sexual activity or interests, however, have elevated risk for low sexual desire and arousal disorders. Men do not exhibit similar associations. The impact of potentially traumatic sexual events is markedly different for women and men. Women respondents reporting any same-sex activity are not at higher risk for sexual dysfunction, while men are. Men reporting any same-sex activity are more than twice as likely to experience premature ejaculation (95% CI, 1.2-3.9) and low sexual desire (95% CI, 1.1-5.7) than men who have not. Arousal disorder appears to be highly associated in women who have experienced sexual victimization through adult-child contact or forced sexual contact. Similarly, male victims of adult-child contact are 3 times as likely to experience erectile dysfunction (95% CI, 1.5-6.6) and approximately 2 times as likely to experience premature ejaculation (95% CI, 1.2-2.9) and low sexual desire (95% CI, 1.1-4.6) than those who have not been victims of adult-child contact. Finally, men who have sexually assaulted women are 3 times as likely to report erectile dysfunction (95% CI, 1.0-12.0). Indeed, traumatic sexual acts continue to exert profound effects on sexual functioning, some effects lasting many years beyond the occurrence of the original event.

Quality-of-Life Concomitants

The experience of sexual dysfunction is highly associated with a number of unsatisfying personal experiences and relationships. Table 5 highlights the associations of categories of sexual dysfunction with emotional and physical satisfaction with sexual partners and with feelings of general happiness. However, no causal order should be assumed since quality-of-life indicators are concomitant outcomes of sexual dysfunction. For women, all categories of sexual dysfunction—low sexual desire, arousal disorder, sexual pain—have strong positive associations with low feelings of physical and emotional satisfaction and low feelings of happiness. Similar to women, men with erectile dysfunction and low sexual desire experience diminished quality of life, but those with premature ejaculation are not affected. In brief, experience of sexual dysfunction is generally associated with poor quality of life; however, these negative outcomes appear to be more extensive and possibly more severe for women than men. In an examination of help-seeking behavior (analysis not shown here, but available on request), we found that roughly 10% and 20% of these afflicted men and women, respectively, sought medical consultation for their sexual problems.

COMMENT

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Demographic factors such as age are strongly predictive of sexual difficulties, particularly erectile dysfunction. Sexual problems are most common among young women and older men. Several factors may explain these differential rates. Since young women are more likely to be single, their sexual activities involve higher rates of partner turnover as well as periodic spells of sexual inactivity. This instability, coupled with inexperience, generates stressful sexual encounters, providing the basis for sexual pain and anxiety. Young men are not similarly affected. Older men are more likely to have trouble maintaining or achieving an erection as well as to lack an interest in sex. Low sexual interest and erection problems are age-dependent disorders, possibly resulting from physiological changes associated with the aging process. Indeed, our results are consistent with those generated by the MMAS, which determined that 9.6% of its sample experienced complete impotence and showed a strong age association increasing from 5% to 15% between subject ages of 40 and 70 years.⁷

Other factors such as poor health and lifestyle are differentially predictive across demographic groups. While nonmarital status is associated with lower overall well-being, part of the higher risk of sexual dysfunction probably stems from differences in sexual lifestyles. Similarly, elevated risks associated with low educational attainment and minority status attest to the fact that better-educated individuals are healthier and have lifestyles that are physically and emotionally less stressful. To understand the factors that predispose individuals to sexual dysfunction, we should analyze risk factors.

The NHSLS data indicate that emotional and stress-related problems among women and men generate elevated risk of experiencing sexual difficulties in all phases of the sexual response cycle. While we caution that the causal order of this relationship is uncertain, these results suggest that psychosocial disturbances affect sexual functioning. This does not imply that the impact of poor health is negligible; in fact, the opposite is demonstrated since age, health problems, and urinary tract infections result in elevated risk of experiencing sexual dysfunction. Rather, both physiological and psychological statuses are independent factors that affect sexual functioning.

Given the salience of emotional distress on sexual dysfunction, we examine 2 underlying sources of psychosocial stress: social status and sexual trauma. The NHSLS data clearly suggest that deteriorating social position negatively affects sexual functioning. Deterioration in economic position induces higher levels of stress, which in turn affects sexual functioning, a result more pervasive among women than men. Future research should be directed toward mapping the social distribution of emotional distress.

With respect to possibly traumatic sexual experiences, our findings are complex and show distinct differences between sexes but clearly provide evidence that these experiences are sources of psychosocial stress. First, we found that the impact of same-sex activity is relevant for men but not women. The source of this difference may be rooted in the subjective meaning of these sex acts, because many male-to-male encounters have involved adult-child contact. We should note that these results assess the impact of historical instances of same-sex activity, not the relationship between homosexuality and sexual problems. Similarly, indicators for sexual victimization show strong effects in persons of both sexes. For women, adult-child contact or forced sex, both generally perpetrated by men, results in increased risk of experiencing arousal disorders. These results support the view that sexual traumas induce lasting psychosocial disturbances, which ultimately affect sexual functioning.²⁸ Similarly, men who were touched sexually before puberty also are more likely to experience all categories of sexual dysfunction. In short, both female and male victims of unwanted sexual contact exhibit long-term changes in sexual functioning.

While the causal relationship between quality-of-life concomitants and sexual dysfunction also remains to be investigated, the strong associations observed in NHSLS data suggest that sexual dysfunction is a largely uninvestigated yet significant public health problem. Recent advances in therapy for erectile dysfunction may increase quality of life for some men. However, since low well-being is strongly associated with female sexual problems, researchers should focus on identifying the consequences of these problems as well as developing appropriate therapies. With the affected population rarely receiving medical therapy for sexual dysfunction, service delivery efforts should be augmented to target high-risk populations.

CONCLUSION

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This report provides the first population-based assessment of sexual dysfunction in the half-century since Kinsey et al.^29-30 The results from the NHSLS indicate that sexual problems are widespread in society and are influenced by both health-related and psychosocial factors. The role of the latter implies that stress-inducing events, due to either individual or social sources, can affect sexual functioning in both men and women. Differing patterns of sexual dysfunction were observed across sex, age, and demographic groups, highlighting the need for further research on etiologic mechanisms. With the strong association between sexual dysfunction and impaired quality of life, this problem warrants recognition as a significant public health concern.

AUTHOR INFORMATION

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Funding/Support: This study was supported in part by grant NICHD RO1-HD28356 from the National Institutes of Health, Bethesda, Md, and by grant 940-1417 from the Ford Foundation, New York, NY.

Acknowledgment: We also would like to express our appreciation for the helpful comments of George Rhodes, MD.

Corresponding Author and Reprints: Edward O. Laumann, PhD, Department of Sociology, University of Chicago, 5848 S University Ave, Chicago, IL 60637 (e-mail: ob01{at}midway.uchicago.edu).

Author Affiliations: Department of Sociology, University of Chicago, Chicago, Ill (Dr Laumann and Mr Paik); and Department of Psychiatry, University of Medicine and Denistry of New Jersey—Robert Wood Johnson Medical School, Piscataway (Dr Rosen).

REFERENCES

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The Thin Line Between Reality and Imagination: Attachment Orientations and the Effects of Relationship Threats on Sexual Fantasies
Birnbaum et al.
Pers Soc Psychol Bull 2008;34:1185-1199.
ABSTRACT  

Prevalence of Low Sexual Desire and Hypoactive Sexual Desire Disorder in a Nationally Representative Sample of US Women
West et al.
Arch Intern Med 2008;168:1441-1449.
ABSTRACT | FULL TEXT  

Testosterone Supplementation to Improve Women's Sexual Satisfaction: Complexities and Unknowns
Basson
ANN INTERN MED 2008;148:620-621.
FULL TEXT  

Sexual Dysfunction in Schizophrenia
Malik
Focus 2008;6:234-238.
ABSTRACT | FULL TEXT  

Female Sex Offenders: Exploring Issues of Personality, Trauma, and Cognitive Distortions
Strickland
J Interpers Violence 2008;23:474-489.
ABSTRACT  

Paradox in Positive Organizational Change
Cameron
Journal of Applied Behavioral Science 2008;44:7-24.
ABSTRACT  

Premature Ovarian Failure and Its Consequences: Vasomotor Symptoms, Sexuality, and Fertility
Schover
JCO 2008;26:753-758.
ABSTRACT | FULL TEXT  

Herpes simplex virus type 2 infection among young uncircumcised men in Kisumu, Kenya
Mehta et al.
Sex. Transm. Infect. 2008;84:42-48.
ABSTRACT | FULL TEXT  

Sexual function changes during the 5 years after high-dose treatment and hematopoietic cell transplantation for malignancy, with case-matched controls at 5 years
Syrjala et al.
Blood 2008;111:989-996.
ABSTRACT | FULL TEXT  

Assessment & management of sexual problems in women
Wylie
JRSM 2007;100:547-550.
FULL TEXT  

History of Past Sexual Abuse in Married Observant Jewish Women
Yehuda et al.
Am. J. Psychiatry 2007;164:1700-1706.
ABSTRACT | FULL TEXT  

Current thoughts on psychosexual disorders in women
Coulson and Crowley
The Obstetrician and Gynaecologist 2007;9:217-222.
ABSTRACT | FULL TEXT  

A Study of Sexuality and Health among Older Adults in the United States
Lindau et al.
NEJM 2007;357:762-774.
ABSTRACT | FULL TEXT  

Prevalence and Predictors of Sexual Dysfunction in Psychiatric Inpatients
Perlman et al.
Psychosomatics 2007;48:309-318.
ABSTRACT | FULL TEXT  

Female Sexual Desire--Beyond Testosterone
Ganz and Greendale
JNCI J Natl Cancer Inst 2007;99:659-661.
FULL TEXT  

Sexual dysfunction in dialysis patients treated with antihypertensive or antidepressive medications: results from the DOPPS
Bailie et al.
Nephrol Dial Transplant 2007;22:1163-1170.
ABSTRACT | FULL TEXT  

Deep dyspareunia and sex life after laparoscopic excision of endometriosis
Ferrero et al.
Hum Reprod 2007;22:1142-1148.
ABSTRACT | FULL TEXT  

Dapoxetine Has No Pharmacokinetic or Cognitive Interactions With Ethanol in Healthy Male Volunteers
Modi et al.
J Clin Pharmacol 2007;47:315-322.
ABSTRACT | FULL TEXT  

Overexpression of arginase in the aged mouse penis impairs erectile function and decreases eNOS activity: influence of in vivo gene therapy of anti-arginase
Bivalacqua et al.
Am. J. Physiol. Heart Circ. Physiol. 2007;292:H1340-H1351.
ABSTRACT | FULL TEXT  

A 60-Year-Old Woman With Sexual Difficulties
Potter
JAMA 2007;297:620-633.
ABSTRACT | FULL TEXT  

Issues for DSM-V: Sexual Dysfunction, Disorder, or Variation Along Normal Distribution: Toward Rethinking DSM Criteria of Sexual Dysfunctions
Balon et al.
Am. J. Psychiatry 2007;164:198-200.
FULL TEXT  

Pesticides and Polychlorinated Biphenyls as Potential Risk Factors for Erectile Dysfunction
Polsky et al.
J Androl 2007;28:28-37.
ABSTRACT | FULL TEXT  

Controversies Regarding Transdermal Androgen Therapy in Postmenopausal Women
Basaria and Dobs
J. Clin. Endocrinol. Metab. 2006;91:4743-4752.
ABSTRACT | FULL TEXT  

Androgen Therapy in Women: An Endocrine Society Clinical Practice Guideline
Wierman et al.
J. Clin. Endocrinol. Metab. 2006;91:3697-3710.
ABSTRACT | FULL TEXT  

SSRI-Associated Sexual Dysfunction
Balon
Am. J. Psychiatry 2006;163:1504-1509.
FULL TEXT  

Pharmacokinetics of dapoxetine, a new treatment for premature ejaculation: impact of age and effects of a high-fat meal.
Dresser et al.
J Clin Pharmacol 2006;46:1023-1029.
ABSTRACT | FULL TEXT  

The 'Pinking' of Viagra Culture: Drug Industry Efforts to Create and Repackage Sex Drugs for Women
Hartley
Sexualities 2006;9:363-378.
ABSTRACT  

Topical Alprostadil Treatment of Female Sexual Arousal Disorder
Kielbasa and Daniel
The Annals of Pharmacotherapy 2006;40:1369-1376.
ABSTRACT | FULL TEXT  

Role of Oxidative Stress in the Pathophysiological Mechanism of Erectile Dysfunction
Agarwal et al.
J Androl 2006;27:335-347.
FULL TEXT  

Use of Sildenafil for Female Sexual Dysfunction
Shields and Hrometz
The Annals of Pharmacotherapy 2006;40:931-934.
ABSTRACT | FULL TEXT  

Randomized Trial of Peer Counseling on Reproductive Health in African American Breast Cancer Survivors
Schover et al.
JCO 2006;24:1620-1626.
ABSTRACT | FULL TEXT  

Sexual Submissiveness in Women: Costs for Sexual Autonomy and Arousal
Sanchez et al.
Pers Soc Psychol Bull 2006;32:512-524.
ABSTRACT  

Disruption of sexual function, FSH secretion, and spermiogenesis in rabbits following developmental exposure to vinclozolin, a fungicide.
Veeramachaneni et al.
Reproduction 2006;131:805-816.
ABSTRACT | FULL TEXT  

Smoking and erectile dysfunction: findings from a representative sample of Australian men.
Millett et al.
Tobacco Control 2006;15:136-139.
ABSTRACT | FULL TEXT  

Sexual health and the new ageing
Gott
Age Ageing 2006;35:106-107.
FULL TEXT  

Single- and multiple-dose pharmacokinetics of dapoxetine hydrochloride, a novel agent for the treatment of premature ejaculation.
Modi et al.
J Clin Pharmacol 2006;46:301-309.
ABSTRACT | FULL TEXT  

Evaluation and Medical Management of Erectile Dysfunction
Beckman et al.
Mayo Clin Proc. 2006;81:385-390.
ABSTRACT | FULL TEXT  

Predictors and Prevalence of Erectile Dysfunction in a Racially Diverse Population
Saigal et al.
Arch Intern Med 2006;166:207-212.
ABSTRACT | FULL TEXT  

Resilient Sexual Desire in Heterosexual Couples
McCarthy et al.
The Family Journal 2006;14:59-64.
ABSTRACT  

Gonadotropin-Releasing Hormone II Stimulates Female Sexual Behavior in Marmoset Monkeys
Barnett et al.
Endocrinology 2006;147:615-623.
ABSTRACT | FULL TEXT  

Is dehydroepiandrosterone a hormone?
Labrie et al.
J Endocrinol 2005;187:169-196.
ABSTRACT | FULL TEXT  

Sexual Dysfunction
IsHak et al.
Focus 2005;3:520-525.
ABSTRACT | FULL TEXT  

A Reintroduction to Clinical Sexuality
Levine
Focus 2005;3:526-531.
ABSTRACT | FULL TEXT  

STIs and sexual dysfunction
Goldmeier and Leiblum
Sex. Transm. Infect. 2005;81:364-364.
FULL TEXT  

Who reports sexual function problems? Empirical evidence from Britain's 2000 National Survey of Sexual Attitudes and Lifestyles
Mercer et al.
Sex. Transm. Infect. 2005;81:394-399.
ABSTRACT | FULL TEXT  

Safety and Efficacy of a Testosterone Patch for the Treatment of Hypoactive Sexual Desire Disorder in Surgically Menopausal Women: A Randomized, Placebo-Controlled Trial
Braunstein et al.
Arch Intern Med 2005;165:1582-1589.
ABSTRACT | FULL TEXT  

Circulating Androgen Levels and Self-reported Sexual Function in Women
Davis et al.
JAMA 2005;294:91-96.
ABSTRACT | FULL TEXT  

Tadalafil Improved Erectile Function at Twenty-Four and Thirty-Six Hours After Dosing in Men With Erectile Dysfunction: US Trial
Young et al.
J Androl 2005;26:310-318.
ABSTRACT | FULL TEXT  

High Proportions of Erectile Dysfunction in Men With the Metabolic Syndrome
Esposito et al.
Diabetes Care 2005;28:1201-1203.
FULL TEXT  

Female sexual dysfunction
Lewis
BMJ 2005;330:E345-E346.
FULL TEXT  

Dietary supplements for female sexual dysfunction
Boone and Shields
Am J Health Syst Pharm 2005;62:574-580.
FULL TEXT  

Sexual Dysfunction in Women With the Metabolic Syndrome
Esposito et al.
Diabetes Care 2005;28:756-756.
FULL TEXT  

Female Sexual Arousal Disorder and Counseling Deliberations
Millner
The Family Journal 2005;13:95-100.
ABSTRACT  

Urologic Complications of Diabetes
Brown et al.
Diabetes Care 2005;28:177-185.
FULL TEXT  

Selective Serotonin Reuptake Inhibitors
JWatch Women's Health 2004;2004:8-8.
FULL TEXT  

Intimacy, commitment, and adaptation: Sexual relationships within long-term marriages
Hinchliff and Gott
Journal of Social and Personal Relationships 2004;21:595-609.
ABSTRACT  

Role of Arginase in the Male and Female Sexual Arousal Response
Kim et al.
J. Nutr. 2004;134:2873S-2879S.
ABSTRACT | FULL TEXT  

Perceptions of Well-Being in Sexual Ill Health: What Role does Age Play?
Hinchliff and Gott
J Health Psychol 2004;9:649-660.
ABSTRACT  

Erectile Dysfunction: Evaluation and New Treatment Options
Carson
Psychosom. Med. 2004;66:664-671.
ABSTRACT | FULL TEXT  

The Link Between LUTS and ED: Clinical and Basic Science Evidence
Schiff and Mulhall
J Androl 2004;25:470-478.
FULL TEXT  

Effect of Lifestyle Changes on Erectile Dysfunction in Obese Men: A Randomized Controlled Trial
Esposito et al.
JAMA 2004;291:2978-2984.
ABSTRACT | FULL TEXT  

Manufacturing Desire:: The Commodification of Female Sexual Dysfunction
Fishman
Social Studies of Science 2004;34:187-218.
ABSTRACT  

Introduction to Sexuality in Late Life
Sharpe
The Family Journal 2004;12:199-205.
ABSTRACT  

Do Sexual Health Care Needs Differ for Women with and without Histories of Abuse?
Nusbaum et al.
Violence Against Women 2004;10:294-311.
ABSTRACT  

Predictors of Sexual Functioning in Ovarian Cancer Patients
Carmack Taylor et al.
JCO 2004;22:881-889.
ABSTRACT | FULL TEXT  

Restoration of Couple's Intimacy and Relationship Vital to Reestablishing Erectile Function
Dunn
JAOA: Journal of the American Osteopathic Association 2004;104:6S-10S.
ABSTRACT | FULL TEXT  

A Twin Study of Erectile Dysfunction
Fischer et al.
Arch Intern Med 2004;164:165-168.
ABSTRACT | FULL TEXT  

Impaired brachial artery endothelium-dependent and -independent vasodilation in men with erectile dysfunction and no other clinical cardiovascular disease
Kaiser et al.
J Am Coll Cardiol 2004;43:179-184.
ABSTRACT | FULL TEXT  

Endothelial Dysfunction in Erectile Dysfunction: Role of the Endothelium in Erectile Physiology and Disease
Bivalacqua et al.
J Androl 2003;24:S17-S37.
FULL TEXT  

Andropause: Symptom Management for Prostate Cancer Patients Treated With Hormonal Ablation
Thompson et al.
The Oncologist 2003;8:474-487.
ABSTRACT | FULL TEXT  

Sexual Satisfaction in Young Adulthood: Cohabitation, Committed Dating or Unattached Life?
Pedersen and Blekesaune
Acta Sociologica 2003;46:179-193.
ABSTRACT  

Problems with sexual function in people attending London general practitioners: cross sectional study
Nazareth et al.
BMJ 2003;327:423.
ABSTRACT | FULL TEXT  

Sexual Function in Men Older Than 50 Years of Age: Results from the Health Professionals Follow-up Study
Bacon et al.
ANN INTERN MED 2003;139:161-168.
ABSTRACT | FULL TEXT  

Intimacy and Women With Type 2 Diabetes: An Exploratory Study Using Focus Group Interviews
Sarkadi and Rosenqvist
The Diabetes Educator 2003;29:641-652.
ABSTRACT  

Female Sexual Dysfunction: Review of the Disorder and Evidence for Available Treatment Alternatives
Miller and Hunt
Journal of Pharmacy Practice 2003;16:200-208.
ABSTRACT  

Sexual side-effects of antidepressant and antipsychotic drugs
Baldwin and Mayers
Adv. Psychiatr. Treat. 2003;9:202-210.
ABSTRACT | FULL TEXT  

Treatment of Female Sexual Dysfunction
Ragucci and Culhane
The Annals of Pharmacotherapy 2003;37:546-555.
ABSTRACT | FULL TEXT  

Gene transfer of extracellular SOD to the penis reduces O₂⁻{middle dot} and improves erectile function in aged rats
Bivalacqua et al.
Am. J. Physiol. Heart Circ. Physiol. 2003;284:H1408-H1421.
ABSTRACT | FULL TEXT  

Prevalence and incidence of prolonged and severe dyspareunia in women: results from a population study
Danielsson et al.
Scand J Public Health 2003;31:113-118.
ABSTRACT  

Vardenafil, a New Phosphodiesterase Type 5 Inhibitor, in the Treatment of Erectile Dysfunction in Men With Diabetes: A multicenter double-blind placebo-controlled fixed-dose study
Goldstein et al.
Diabetes Care 2003;26:777-783.
ABSTRACT | FULL TEXT