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Low Risk-Factor Profile and Long-term Cardiovascular and Noncardiovascular Mortality and Life Expectancy
Findings for 5 Large Cohorts of Young Adult and Middle-Aged Men and Women
Jeremiah Stamler, MD;
Rose Stamler, MA;
James D. Neaton, PhD;
Deborah Wentworth, MA;
Martha L. Daviglus, MD, PhD;
Dan Garside, MA;
Alan R. Dyer, PhD;
Kiang Liu, PhD;
Philip Greenland, MD
JAMA. 1999;282:2012-2018.
ABSTRACT
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Context Three major coronary risk factors—serum cholesterol level, blood pressure, and smoking—increase incidence of coronary heart disease (CHD) and related end points. In previous investigations, risks for low-risk reference groups were estimated statistically because samples contained too few such people to measure risk.
Objective To measure long-term mortality rates for individuals with favorable levels for all 3 major risk factors, compared with others.
Design Two prospective studies, involving 5 cohorts based on age and sex, that enrolled persons with a range of risk factors. Low risk was defined as serum cholesterol level less than 5.17 mmol/L (<200 mg/dL), blood pressure less than or equal to120/80 mm Hg, and no current cigarette smoking. All persons with a history of diabetes, myocardial infarction (MI), or, in 3 of 5 cohorts, electrocardiogram (ECG) abnormalities, were excluded.
Setting and Participants In 18 US cities, a total of 72,144 men aged 35 through 39 years and 270,671 men aged 40 through 57 years screened (1973-1975) for the Multiple Risk Factor Intervention Trial (MRFIT); in Chicago, a total of 10,025 men aged 18 through 39 years, 7490 men aged 40 through 59 years, and 6229 women aged 40 through 59 years screened (1967-1973) for the Chicago Heart Association Detection Project in Industry (CHA) (N = 366,559).
Main Outcome Measures Cause-specific mortality during 16 (MRFIT) and 22 (CHA) years, relative risks (RRs) of death, and estimated greater life expectancy, comparing low-risk subcohorts vs others by age strata.
Results Low-risk persons comprised only 4.8% to 9.9% of the cohorts. All 5 low-risk groups experienced significantly and markedly lower CHD and cardiovascular disease death rates than those who had elevated cholesterol level, or blood pressure, or smoked. For example, age-adjusted RRs of CHD mortality ranged from 0.08 for CHA men aged 18 to 39 years to 0.23 for CHA men aged 40 through 59 years. The age-adjusted relative risks (RRs) for all cardiovascular disease mortality ranged from 0.15 for MRFIT men aged 35 through 39 years to 0.28 for CHA men aged 40 through 59 years. The age-adjusted RR for all-cause mortality rate ranged from 0.42 for CHA men aged 40 through 59 years to 0.60 for CHA women aged 40 through 59 years. Estimated greater life expectancy for low-risk groups ranged from 5.8 years for CHA women aged 40 through 59 years to 9.5 years for CHA men aged 18 through 39 years.
Conclusions Based on these very large cohort studies, for individuals with favorable levels of cholesterol and blood pressure who do not smoke and do not have diabetes, MI, or ECG abnormalities, long-term mortality is much lower and longevity is much greater. A substantial increase in the proportion of the population at lifetime low risk could contribute decisively to ending the CHD epidemic.
INTRODUCTION
Long-term, population-based, prospective studies have amassed extensive data on relationships of major coronary-cardiovascular risk factors—particularly serum cholesterol level, blood pressure, and cigarette smoking—with incidence of coronary heart disease (CHD), stroke, and cardiovascular disease (CVD), to mortality from these causes and all causes and longevity.1-7 These relationships have been well summarized as " . . . strong, continuous, graded, consistent, independent, predictive, and etiologically significant for those with and without coronary heart disease."7 The judgment on etiologic significance is based on the consistent results of many epidemiological studies and on concordant findings from clinical and postmortem investigations and animal experimentation. This judgment is reinforced by data from randomized controlled trials demonstrating that sustained lowering of high blood pressure or elevated serum cholesterol level produces sizable reductions in CHD-CVD incidence and in cause-specific and all-cause mortality.7-14 These positive results have been obtained repeatedly, even though trials have been undertaken in middle-aged and older people after decades of exposure to these adverse traits. Extensive data also document that smoking cessation has similar favorable effects.15-16
Most epidemiologic research on the impact of major risk factors deals with the predictive value of higher levels of such factors. In assessments of their combined impact, risks of those with favorable status for all 3 major risk factors have been estimated statistically, for example, by extrapolation down multiple logistic smoothed curves.3 This was necessary because in the population samples studied, numbering in the hundreds or thousands, too few people had low levels of all major risk factors—hence too few CVD events—to permit direct measurement of risk.
Large, long-term studies permit measured estimates based on actual observed mortality. In this article, we use data on 5 cohorts from 2 studies, the Multiple Risk Factor Intervention Trial (MRFIT) and the Chicago Heart Association Detection Project in Industry (CHA): 2 cohorts of young adult men, 2 cohorts of middle-aged men, and 1 cohort of middle-aged women—366,559 people all together.
METHODS
Published reports on the MRFIT and CHA cohorts detail their baseline screening methods.5-6,17-19 We provide a summary of these here.
Multiple Risk Factor Intervention Trial
All together, 361,662 men aged 35 through 57 years were screened in 1973-1975 at 22 centers in 18 US cities for recruitment for MRFIT. The 342,815 men with complete baseline risk factor data are the focus here, stratified into 2 cohorts: those aged 35 through 39 years (n = 72,144) and 40 through 57 years (n = 270,671). Trial eligibility was based on a man's major risk factor profile; therefore, initial screening included measurements only of blood pressure and serum cholesterol level; current smoking (by questionnaire), including number of cigarettes per day; and conditions for exclusion, ie, drug treatment for diabetes and previous hospitalization for myocardial infarction (MI). Blood pressure was measured according to a standardized protocol by trained certified staff, using a mercury sphygmomanometer, with the man seated. Diastolic blood pressure (DBP) was measured at the fifth Korotkoff sound. Three readings per individual were taken; the average of the second and third systolic blood pressure (SBP) measurements was used for analyses. Serum total cholesterol level was determined, in 15 standardized local laboratories, by the Lieberman-Burchard color reaction and use of serum calibrators to yield values equivalent to Abell-Kendall reference values.17-19
Vital status of the men is ascertained periodically through the US National Death Index. Prior to 1979, Social Security Administration records were used. With a mean follow-up of 16 years, 38,265 deaths have been identified; cause of death is known for 98.9% of decedents. Underlying cause of death was coded by a nosologist using the International Classification of Diseases, Ninth Revision (ICD-9).20
Chicago Heart Association Detection Project in Industry
Employees of 84 Chicago-area companies and organizations, about 75,000 people, were invited to participate. The response rate was 55%. Screening was done by 2 trained and standardized 4-person field teams who collected demographic information, medical history, and medical treatment data; information on past and present smoking status; 1 measurement of height, weight, heart rate, and supine blood pressure; resting electrocardiogram (ECG); and venipuncture for blood chemistry measurements. Serum total cholesterol level was determined by the Levine and Zak method.6, 17 The criteria of the Pooling Project3 were used to code ECG abnormalities. Three cohorts are the focus here: men aged 18 through 39 years, men aged 40 through 59 years, and women aged 40 through 59 years.
Methods of follow-up to ascertain vital status include local procedures and use of Social Security Administration and National Death Index records. With a mean follow-up of 22 years, vital status has been determined for more than 99% of the cohorts. For each decedent, underlying cause of death was coded by a trained staff professional, using the International Classification of Diseases, Eighth Revision (ICD-8).21
Low-Risk Criteria
Criteria for defining a person as low risk were all of the following at baseline: serum cholesterol level less than 5.17 mmol/L (<200 mg/dL), SBP/DBP of 120/80 mm Hg or lower; not a current smoker; no history of diabetes or MI; and, for the 3 CHA cohorts, no ECG abnormalities.
Deaths from all CHDs were defined for MRFIT cohorts as ICD-9 codes 410 through 414 and 429.9, for CHA cohorts as ICD-8 codes 410 through 414; MI, code 410; stroke, codes 430 through 438; all CVD, codes 390 through 459; all cancers, codes 140 through 209; violence, for MRFIT cohorts ICD-9 codes 800 through 999, for CHA cohorts ICD-8 codes E800 through E999 exclusive of codes E930 through E936. Coders were blinded to baseline data.
Statistical Methods
To focus on risk for persons with favorable levels of serum cholesterol, blood pressure, and no tobacco use (all 3 combined), compared with persons with adverse levels of 1 or more of these, persons with histories of diabetes or MI were excluded (all 5 cohorts), as were persons with ECG abnormalities (the 3 CHA cohorts). Mortality rates for low-risk and other persons were age-adjusted by the direct method to the age distribution of all persons in an age stratum. Cox proportional hazards regression was used to calculate age-adjusted relative risks (RRs) and their 95% confidence intervals (CIs) for low-risk compared with other persons.
Cox multivariate proportional hazards regression was used to calculate coefficients for the relation of baseline major risk factors to all-cause mortality for each cohort. Coefficients were used to estimate number of years of greater life expectancy for each low-risk subcohort compared with other persons of the same cohort.17 Thus, the coefficient for the relationship of SBP to all-cause mortality in the Cox multivariate analyses for CHA men aged 18 through 39 years is 0.0116. Average SBP for the 942 low-risk men was 116.0 mm Hg; for the 9083 other men, 136.0 mm Hg; by exponentiation, estimated RR of death is e-0.0116x20 = e-0.232 = 0.793. To estimate impact of this lower SBP on life expectancy, we used the concomitant Cox coefficient for the relationship of age to all-cause mortality, 0.0703. The product for SBP exponentiation, 0.0116 x 20 = 0.232, is also obtained when the coefficient for age, 0.0703, is multiplied by 3.3, which indicates that SBP of 116 mm Hg vs 136 mm Hg is equivalent to being, on average, 3.3 years younger: eg, age 26.7 years rather than age 30 years. From US life tables,22 male expectation of life at age 30 years is 44.1 years; at age 26.7 years, 47.2 years: ie, 3.1 years estimated greater life expectancy is attributable to SBP 116 mm Hg vs SBP 136 mm Hg. Similar calculations yield data on impact on life expectancy of favorable status of the low-risk subcohort for serum cholesterol level and smoking compared with the other subcohort. These 3 estimates are summed to give the overall estimate presented here.
RESULTS
Baseline Findings: Low-Risk Subcohorts vs Others
The proportion of persons meeting low-risk criteria was small: for young adult men, 9.9% (MRFIT) and 9.4% (CHA); for middle-aged men, 6.0% (MRFIT) and 4.8% (CHA); and for middle-aged women, 6.8% (CHA) (Table 1 and Table 2). In accordance with low-risk criteria, average blood pressure and serum cholesterol levels were much lower for low-risk subcohorts compared with other persons. Body mass index was lower for CHA low-risk subcohorts compared with others (Table 2).
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Table 1. Baseline Descriptive Statistics: MRFIT Low-Risk Subcohorts and Other Men Aged 35-39 and 40-57 Years*
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Table 2. Baseline Descriptive Statistics: Low-Risk Subcohorts and Other Men Aged 18-39 and 40-59 Years, Low-Risk Subcohorts and Other Women Aged 40-59 Years, CHA Study*
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Mortality by Cause, Low-Risk Subcohorts vs Others
Coronary Heart Disease
The CHD mortality rate was much lower for low-risk subcohorts than for others, by 86% to 92% for low-risk young adult men (<40 years) and 77% to 79% for low-risk middle-aged subcohorts (Table 3). Findings were similar for death attributed to acute MI.
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Table 3. Mortality From Coronary Heart Disease and All Cardiovascular Diseases for Low-Risk Subcohorts and Others*
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For low-risk subcohorts, CHD death accounted for a much smaller proportion of all death than for others (Table 3). This finding was especially prominent for low-risk young adult men, with CHD mortality only 6% to 8% of all mortality vs 25% to 29% for others.
All CVDs
All CVD mortality was much lower for low-risk subcohorts than for others by 72% to 85% (Table 3).
Stroke, All Cancers, Violence, and All Other Mortality
There were no stroke deaths in the 2 young adult low-risk subcohorts. For the 2 middle-aged, male low-risk subcohorts, stroke mortality was lower than for others by 52% to 76%. Mortality from cancers was consistently lower for low-risk subcohorts compared with others: by 44% to 56% for the 4 male low-risk subcohorts and 17% for the female low-risk subcohort. No results significantly supported the hypothesis that low serum cholesterol level is associated with greater risk of violent death. For the 2 young adult cohorts, mortality from all other causes was similar for low-risk men and others. For the 3 middle-aged cohorts, RR was lower for low-risk groups than others by 36% to 86%(Table 4).
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Table 4. Mortality From Stroke, Cancer, Violence, and Other Causes for Low-Risk Subcohorts and Others*
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All-Cause Mortality
Mortality from all causes was consistently and markedly lower for low-risk groups vs others: by 50% to 58% for men and 40% for women (Table 5). Estimated greater life expectancy for low-risk subcohorts vs others ranged from 5.8 years to 9.5 years.
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Table 5. Mortality From All Causes, Low-Risk Subcohorts and Others, and Estimated Greater Life Expectancy for Low-Risk Subcohort Compared With Others*
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COMMENT
Large sample sizes and long follow-up of the 5 MRFIT and CHA cohorts enabled measurement of actual cause-specific and all-cause mortality experience of adults assessed to be low risk at baseline. Results were consistent qualitatively and quantitatively for all 5 cohorts, young adult and middle-aged, male and female, free at baseline of a history of diabetes and MI, and of ECG abnormalities (CHA cohorts). Only a small minority (<10%) met all criteria for low risk—serum cholesterol level under 5.17 mmol/L (<200 mg/dL), SBP/DBP of 120/80 mm Hg or less, and no cigarette smoking. During long-term follow-up, low-risk subcohorts, compared with others, consistently experienced significantly and markedly lower CHD death rates by 77% to 92%, and CHD mortality was a much smaller proportion of all-cause mortality. Findings for stroke and for all CVD paralleled those for CHD. There was no evidence of significant countervailing non-CVD mortality for low-risk subcohorts; rather, their cancer mortality was consistently lower. Consequently, compared with others, all-cause mortality was markedly lower for low-risk persons (by 40% to 58%), and their estimated longevity was much greater (by 5.8 to 9.5 years).
These findings directly confirm earlier statistical estimates of the benefits of low-risk status. For example, in the national cooperative Pooling Project, risk of a first major coronary event was estimated by multiple logistic regression to be lower by 70% for middle-aged men in the lowest quintile of risk, compared with all other men.3 Concordantly, recent data from the Framingham Study estimate CHD risk to be considerably reduced for low-risk men and women compared with all men and women.23 Results for the 5 MRFIT and CHA cohorts go beyond such estimates in several respects: (1) they are actual observations, not extrapolations from regression analyses; (2) they are not only for middle-aged men and women, but also young adult men; (3) they demonstrate the favorable impact of low-risk status not only on CHD incidence, but also CHD mortality, risk of fatal stroke, all CVD, all cancers, and all causes, without any significant evidence of countervailing mortality risks; (4) they indicate that low-risk status is associated with greater life expectancy by several years; and (5) additional analyses (reported previously) on the CHA cohorts show further that low risk in middle age is associated with lower average annual costs for medical care in older age.24
These data on the benefits of low risk are almost certainly underestimates due to both misclassification of individuals with a single measurement of the 3 major risk factors25 and lack of data on the fourth independent major risk factor, adverse dietary pattern.1-2,5-6,8, 17, 19, 26 Data on participant exercise habits were also missing. In this regard, the 2 diet-dependent major risk factors (serum cholesterol level and blood pressure) may be viewed not only as etiologically significant traits, but also as markers of other lifestyle characteristics contributing to favorable outcomes for low-risk subcohorts. This inference is supported by the CHA data showing lower average body mass index for low-risk individuals vs others.
The data here challenge the view that the major risk factors " . . . explain at most half of all myocardial infarctions." 27 Despite underestimation, favorable status for all 3 major risk factors consistently predicted long-term CHD and MI mortality rates that are lower by much more than 50%: by 86% to 92% for young adult men and 77% to 79% for middle-aged persons compared with others. Consequently, for low-risk subcohorts, in contrast to others, MI and CHD mortality rates were not at epidemic levels, were not main causes of death, and did not account for a large proportion of all deaths. Available data indicate that this favorable status for low-risk persons holds for both African Americans and whites, and for those of lower and higher socioeconomic status.28
These findings are relevant for the national effort to end the CHD-CVD epidemic. They lend strong support to the concept2 that a strategy based on identifying, evaluating, and treating people with risk factors is not enough. A population-wide strategy is critical to prevent and reduce the magnitude of all the major risk factors, first and foremost by safe nutritional-hygienic means, so that a substantial increase is achieved in the proportion of people in the population who, throughout life, have favorable levels for all the major risk factors and so are at low risk. For upcoming generations, this means encouraging favorable behaviors beginning in early childhood in regard to eating, drinking, exercising, and smoking. For others (particularly older children, teenagers, and young adults), this strategy emphasizes efforts to preserve favorable risk factor status for those who still have none of the major risk factors.
Genetic makeup undoubtedly influenced propensity to fall into low-risk categories. However, as shown by multiple data sets on groups such as American Seventh Day Adventists, Chinese, Greeks, Italians, Japanese, and South Africans, adult population average serum cholesterol level lower than 5.17 mmol/L (<200 mg/dL) is widely prevalent.1-2 For the US population as a whole in the 1990s, mean serum cholesterol level has fallen almost to the national health goal for the year 2000 of no more than 5.17 mmol/L (200 mg/dL).29 Similarly, extensive data are available on isolated populations around the world with average adult SBP/DBP of 120/80 mm Hg or less, with little or no blood pressure rise during adulthood, and with little or no hypertension30: favorable blood pressure patterns that are not due to unusual genetic makeup, since with migration and adoption of modern lifestyles these populations too develop adverse blood pressure levels.
Therefore, lifestyle also clearly influences who will fall into the low risk-factor group. Since the 1960s, nutritional recommendations have been available for prevention of dyslipidemia in the form of advice to decrease intake of dietary total fat, saturated fat, cholesterol; partially replace saturated fat with monounsaturated and polyunsaturated fat; increase intake of dietary fiber, especially water-soluble fiber; and prevent or reduce overweight.1-2,8, 19, 26, 29, 31 Average serum cholesterol levels of the adult population have decreased from approximately 6.21 mmol/L (240 mg/dL) to less than 5.30 mmol/L (205 mg/dL).29 More recently, lifestyle recommendations have been set down for prevention of adverse blood pressure levels. These initially involved avoidance of high salt intake, inadequate potassium intake, excess alcohol use, overweight, and sedentary habits,30-32 and have been expanded to include high intake of fruits and vegetables, fat-free and low-fat protein sources, and low intake of lipid-rich foods (ie, reduced dietary total fat, saturated fat, and cholesterol).7, 33-34 National survey data indicate that average blood pressure levels of Americans and rates of high blood pressure are lower as a result of improved lifestyles, independent of effects of antihypertensive drug treatment.35 All these data support the concept that lifestyles, particularly nutritional habits, interdigitate with polygenic propensities (widespread in the population) to influence average serum lipid and blood pressure levels of both individuals and the overall population. Adverse levels are not fixed consequences of the genome; they are widely amenable to prevention by safe nutritional-hygienic means, with resultant sizable increases in the proportion of the population at low risk.
In summary, data from large, population-based, prospective studies indicate that lifetime favorable status in regard to all 3 major CHD-CVD risk factors (serum cholesterol level, blood pressure, and smoking) leads to low mortality rates from CHD, CVD, and all causes and increased life expectancy. The extensive findings support a strategic emphasis on population-wide primary prevention of all major risk factors as a key component of the effort to end the CHD-CVD epidemic. Research advances have supplied the scientific information to make implementation of this strategic component widely feasible. The challenge is to mobilize the societal will and resources to realize these goals in all population strata to help end the CHD-CVD epidemic early in the next century.
AUTHOR INFORMATION
Funding/Support: The Multiple Risk Factor Intervention Trial (MRFIT) investigation has been a collaborative research endeavor with the National Heart, Lung, and Blood Institute, Bethesda, Md (contract and grant support) (HL28715). The Chicago Heart Association (CHA) research has been supported by the American Heart Association and its Chicago and Illinois affiliates; the Illinois Regional Medical Program; the National Heart, Lung, and Blood Institute (HL21010); the Chicago Health Research Foundation; and private donors.
Acknowledgment: We thank the many colleagues in the 22 clinical centers across the United States where the 361,662 men were screened for MRFIT, in the laboratories where the serum cholesterol analyses were done, and in the MRFIT Coordinating Center, Division of Biometry, School of Public Health, University of Minnesota, Minneapolis, where the analyses of the MRFIT data were done. Comprehensive listings of MRFIT colleagues are given in references 18 and 19 cited here. The work of the CHA was accomplished thanks to the invaluable cooperation of 84 Chicago-area companies and organizations, their officers, staff, and employees whose volunteer efforts made the project possible. We also acknowledge all those in the Chicago Heart Association—staff and volunteers—serving the project. Many of these individuals are cited by name in reference 17.
Corresponding Author and Reprints: Jeremiah Stamler, MD, Department of Preventive Medicine, Northwestern University Medical School, 680 N Lake Shore Dr, Suite 1102 (D335), Chicago, IL 60611.
Author Affiliations: Department of Preventive Medicine, Northwestern University Medical School, Chicago, Ill (Drs Stamler, Daviglus, Dyer, Liu, and Greenland, Ms Stamler, and Mr Garside); and Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis (Dr Neaton and Ms Wentworth). Ms Stamler died February 28, 1998.
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Am J Epidemiol 2009;170:229-236.
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Heart Disease and Stroke Statistics--2009 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
WRITING GROUP MEMBERS et al.
Circulation 2009;119:e21-e181.
FULL TEXT
Absolute and Attributable Risks of Heart Failure Incidence in Relation to Optimal Risk Factors
Folsom et al.
Circ Heart Fail 2009;2:11-17.
ABSTRACT
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Cardiovascular risk reduction for African-American men through health empowerment and anger management
Stephens et al.
Health Education Journal 2008;67:208-218.
ABSTRACT
Primary Prevention of Stroke: Impact of Healthy Lifestyle
Gorelick
Circulation 2008;118:904-906.
FULL TEXT
Primary Prevention of Stroke by Healthy Lifestyle
Chiuve et al.
Circulation 2008;118:947-954.
ABSTRACT
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Preventing Heart Disease in the 21st Century: Implications of the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Study
McGill et al.
Circulation 2008;117:1216-1227.
FULL TEXT
Relation of plasma lipids to all-cause mortality in Caucasian, African-American and Hispanic elders
Akerblom et al.
Age Ageing 2008;37:207-213.
ABSTRACT
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Exceptional Longevity in Men: Modifiable Factors Associated With Survival and Function to Age 90 Years
Yates et al.
Arch Intern Med 2008;168:284-290.
ABSTRACT
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Resting Heart Rate in Middle Age and Diabetes Development in Older Age
Carnethon et al.
Diabetes Care 2008;31:335-339.
ABSTRACT
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Heart Disease and Stroke Statistics--2008 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Writing Group Members et al.
Circulation 2008;117:e25-e146.
FULL TEXT
Biomarkers of Inflammation and Thrombosis as Predictors of Near-Term Mortality in Patients with Peripheral Arterial Disease: A Cohort Study
Vidula et al.
ANN INTERN MED 2008;148:85-93.
ABSTRACT
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Special Article: Physical Activity, Physical Fitness, and Cardiovascular Risk Factors in Childhood
Gidding
AMERICAN JOURNAL OF LIFESTYLE MEDICINE 2007;1:499-505.
ABSTRACT
Time to End the Mixed and Often Incorrect Messages About Prevention and Treatment of Atherosclerotic Cardiovascular Disease
Greenland and Lloyd-Jones
J Am Coll Cardiol 2007;50:2133-2135.
FULL TEXT
Combined Effect of Low-Risk Dietary and Lifestyle Behaviors in Primary Prevention of Myocardial Infarction in Women
Akesson et al.
Arch Intern Med 2007;167:2122-2127.
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Changes in Triglyceride Levels and Risk for Coronary Heart Disease in Young Men
Tirosh et al.
ANN INTERN MED 2007;147:377-385.
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Beneficial Effects of Valsartan in Asymptomatic Individuals With Vascular or Cardiac Abnormalities: The DETECTIV Pilot Study
Duprez et al.
J Am Coll Cardiol 2007;50:835-839.
ABSTRACT
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Electrocardiographic abnormalities in patients with cluster headache on verapamil therapy
Cohen et al.
Neurology 2007;69:668-675.
ABSTRACT
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Socioeconomic Position, Co-Occurrence of Behavior-Related Risk Factors, and Coronary Heart Disease: the Finnish Public Sector Study
Kivimaki et al.
AJPH 2007;97:874-879.
ABSTRACT
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Absolute and Attributable Risks of Cardiovascular Disease Incidence in Relation to Optimal and Borderline Risk Factors: Comparison of African American With White Subjects--Atherosclerosis Risk in Communities Study
Hozawa et al.
Arch Intern Med 2007;167:573-579.
ABSTRACT
| FULL TEXT
Consistently Stable or Decreased Body Mass Index in Young Adulthood and Longitudinal Changes in Metabolic Syndrome Components: The Coronary Artery Risk Development in Young Adults Study
Lloyd-Jones et al.
Circulation 2007;115:1004-1011.
ABSTRACT
| FULL TEXT
Heart Disease and Stroke Statistics--2007 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Rosamond et al.
Circulation 2007;115:e69-e171.
FULL TEXT
An Overview Of Cardiovascular Disease Burden In The United States
Mensah and Brown
Health Aff (Millwood) 2007;26:38-48.
ABSTRACT
| FULL TEXT
The Prevention Of Cardiovascular Disease: Have We Really Made Progress?
Pearson
Health Aff (Millwood) 2007;26:49-60.
ABSTRACT
| FULL TEXT
Cardiovascular Disease Risk Factor Knowledge in Young Adults and 10-year Change in Risk Factors: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Lynch et al.
Am J Epidemiol 2006;164:1171-1179.
ABSTRACT
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Risk Factors for Mortality in Middle-aged Women
Tice et al.
Arch Intern Med 2006;166:2469-2477.
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Cardiovascular Risk in Midlife and Psychological Well-being Among Older Men.
Strandberg et al.
Arch Intern Med 2006;166:2266-2271.
ABSTRACT
| FULL TEXT
Healthy Lifestyle Factors in the Primary Prevention of Coronary Heart Disease Among Men: Benefits Among Users and Nonusers of Lipid-Lowering and Antihypertensive Medications
Chiuve et al.
Circulation 2006;114:160-167.
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| FULL TEXT
Comparison of risk factors for cardiovascular mortality in black and white adults.
Carnethon et al.
Arch Intern Med 2006;166:1196-1202.
ABSTRACT
| FULL TEXT
A tale of three species rabbits, chickens and humans: an interview with clinical trials pioneer Jeremiah Stamler
Wittes
Clin Trials 2006;3:320-334.
Favorable Cardiovascular Risk Profile (Low Risk) and 10-Year Stroke Incidence in Women and Men: Findings from 12 Italian Population Samples
Giampaoli et al.
Am J Epidemiol 2006;163:893-902.
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Explaining the social gradient in coronary heart disease: comparing relative and absolute risk approaches
Lynch et al.
J. Epidemiol. Community Health 2006;60:436-441.
ABSTRACT
| FULL TEXT
Heart Disease and Stroke Statistics--2006 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Thom et al.
Circulation 2006;113:e85-e151.
FULL TEXT
Prediction of Lifetime Risk for Cardiovascular Disease by Risk Factor Burden at 50 Years of Age
Lloyd-Jones et al.
Circulation 2006;113:791-798.
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Dietary Recommendations for Children and Adolescents: A Guide for Practitioners
American Heart Association et al.
Pediatrics 2006;117:544-559.
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Midlife Body Mass Index and Hospitalization and Mortality in Older Age
Yan et al.
JAMA 2006;295:190-198.
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Normal Fasting Plasma Glucose Levels and Type 2 Diabetes in Young Men
Tirosh et al.
NEJM 2005;353:1454-1462.
ABSTRACT
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Dietary Recommendations for Children and Adolescents: A Guide for Practitioners: Consensus Statement From the American Heart Association
Endorsed by the American Academy of Pediatrics et al.
Circulation 2005;112:2061-2075.
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Prevalence of Cardiovascular Disease Risk Factor Clustering Among the Adult Population of China: Results From the International Collaborative Study of Cardiovascular Disease in Asia (InterAsia)
Gu et al.
Circulation 2005;112:658-665.
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Race/Ethnicity, Income, Major Risk Factors, and Cardiovascular Disease Mortality
Thomas et al.
AJPH 2005;95:1417-1423.
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Cardiovascular Risk Profile Earlier in Life and Medicare Costs in the Last Year of Life
Daviglus et al.
Arch Intern Med 2005;165:1028-1034.
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Healthy Lifestyle Characteristics Among Adults in the United States, 2000
Reeves and Rafferty
Arch Intern Med 2005;165:854-857.
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Commentary: Incubation of coronary heart disease--recent developments
McCarron and Davey Smith
Int J Epidemiol 2005;34:248-250.
FULL TEXT
Relative Importance of Borderline and Elevated Levels of Coronary Heart Disease Risk Factors
Vasan et al.
ANN INTERN MED 2005;142:393-402.
ABSTRACT
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Cardiovascular Risk Factors in Iranian Adults according to Educational Levels: Isfahan Healthy Heart Program
Roohafza et al.
Asia Pac J Public Health 2005;17:9-14.
ABSTRACT
Metabolic Syndrome Variables at Low Levels in Childhood Are Beneficially Associated With Adulthood Cardiovascular Risk: The Bogalusa Heart Study
Chen et al.
Diabetes Care 2005;28:126-131.
ABSTRACT
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Today's Agenda: We Must Focus on Achieving Favorable Levels of All Risk Factors Simultaneously
Daviglus and Liu
Arch Intern Med 2004;164:2086-2087.
FULL TEXT
Prevalence of Heart Disease and Stroke Risk Factors in Persons With Prehypertension in the United States, 1999-2000
Greenlund et al.
Arch Intern Med 2004;164:2113-2118.
ABSTRACT
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Favorable Cardiovascular Risk Profile in Young Women and Long-term Risk of Cardiovascular and All-Cause Mortality
Daviglus et al.
JAMA 2004;292:1588-1592.
ABSTRACT
| FULL TEXT
The Relative Impact of Inadequate Primary and Secondary Prevention on Cardiovascular Mortality in the United States
Qureshi et al.
Stroke 2004;35:2346-2350.
ABSTRACT
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Short-term Menopausal Hormone Therapy for Symptom Relief: An Updated Decision Model
Col et al.
Arch Intern Med 2004;164:1634-1640.
ABSTRACT
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Haemostatic/inflammatory markers predict 10-year risk of IHD at least as well as lipids: the Caerphilly collaborative studies
Yarnell et al.
Eur Heart J 2004;25:1049-1056.
ABSTRACT
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Parental Cardiovascular Disease as a Risk Factor for Cardiovascular Disease in Middle-aged Adults: A Prospective Study of Parents and Offspring
Lloyd-Jones et al.
JAMA 2004;291:2204-2211.
ABSTRACT
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Women and Heart Disease: The Role of Diabetes and Hyperglycemia
Barrett-Connor et al.
Arch Intern Med 2004;164:934-942.
ABSTRACT
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Sickness absence as a predictor of mortality among male and female employees
Vahtera et al.
J. Epidemiol. Community Health 2004;58:321-326.
ABSTRACT
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Social class differences in coronary heart disease in middle-aged British men: implications for prevention
Emberson et al.
Int J Epidemiol 2004;33:289-296.
ABSTRACT
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Trends in Self-reported Multiple Cardiovascular Disease Risk Factors Among Adults in the United States, 1991-1999
Greenlund et al.
Arch Intern Med 2004;164:181-188.
ABSTRACT
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Traditional Risk Factors for Coronary Heart Disease--Reply
Greenland
JAMA 2004;291
:300-301.
FULL TEXT
Response Rates to a Questionnaire 26 Years after Baseline Examination with Minimal Interim Participant Contact and Baseline Differences between Respondents and Nonrespondents
Pirzada et al.
Am J Epidemiol 2004;159:94-101.
ABSTRACT
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Inflammation-Sensitive Plasma Proteins and Incidence of Myocardial Infarction in Men With Low Cardiovascular Risk
Engstrom et al.
Arterioscler. Thromb. Vasc. Bio. 2003;23:2247-2251.
ABSTRACT
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Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
Chobanian et al.
Hypertension 2003;42:1206-1252.
ABSTRACT
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Body Mass Index in Middle Age and Health-Related Quality of Life in Older Age: The Chicago Heart Association Detection Project in Industry Study
Daviglus et al.
Arch Intern Med 2003;163:2448-2455.
ABSTRACT
| FULL TEXT
Favorable Cardiovascular Risk Profile in Middle Age and Health-Related Quality of Life in Older Age
Daviglus et al.
Arch Intern Med 2003;163:2460-2468.
ABSTRACT
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Re-assessing the contribution of serum total cholesterol, blood pressure and cigarette smoking to the aetiology of coronary heart disease: impact of regression dilution bias
Emberson et al.
Eur Heart J 2003;24:1719-1726.
ABSTRACT
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Major Risk Factors as Antecedents of Fatal and Nonfatal Coronary Heart Disease Events
Greenland et al.
JAMA 2003;290:891-897.
ABSTRACT
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Prevalence of Conventional Risk Factors in Patients With Coronary Heart Disease
Khot et al.
JAMA 2003;290:898-904.
ABSTRACT
| FULL TEXT
Emerging Risk Factors for Atherosclerotic Vascular Disease: A Critical Review of the Evidence
Hackam and Anand
JAMA 2003;290:932-940.
ABSTRACT
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Sickness absence as a global measure of health: evidence from mortality in the Whitehall II prospective cohort study
Kivimaki et al.
BMJ 2003;327:364.
ABSTRACT
| FULL TEXT
Selecting Asymptomatic Patients for Coronary Computed Tomography or Electrocardiographic Exercise Testing
Greenland and Gaziano
NEJM 2003;349:465-473.
FULL TEXT
Middle Age Cardiovascular Risk Factors and Abdominal Aortic Aneurysm in Older Age
Rodin et al.
Hypertension 2003;42:61-68.
ABSTRACT
| FULL TEXT
Task force #1--identification of coronary heart disease risk: is there a detection gap?
Pasternak et al.
J Am Coll Cardiol 2003;41:1863-1874.
FULL TEXT
Smoking reduction, smoking cessation, and incidence of fatal and non-fatal myocardial infarction in Denmark 1976-1998: a pooled cohort study
Godtfredsen et al.
J. Epidemiol. Community Health 2003;57:412-416.
ABSTRACT
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Impact of Electron Beam Tomography, With or Without Case Management, on Motivation, Behavioral Change, and Cardiovascular Risk Profile: A Randomized Controlled Trial
O'Malley et al.
JAMA 2003;289:2215-2223.
ABSTRACT
| FULL TEXT
Improving Risk of Coronary Heart Disease: Can a Picture Make the Difference?
Greenland
JAMA 2003;289:2270-2272.
FULL TEXT
Birth Weight and Blood Cholesterol Level: A Study in Adolescents and Systematic Review
Owen et al.
Pediatrics 2003;111:1081-1089.
ABSTRACT
| FULL TEXT
American Heart Association Guide for Improving Cardiovascular Health at the Community Level: A Statement for Public Health Practitioners, Healthcare Providers, and Health Policy Makers From the American Heart Association Expert Panel on Population and Prevention Science
Pearson et al.
Circulation 2003;107:645-651.
FULL TEXT
Family history, longevity, and risk of coronary heart disease: the PRIME Study
Yarnell et al.
Int J Epidemiol 2003;32:71-77.
ABSTRACT
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The search for new risk factors for coronary heart disease: occupational therapy for epidemiologists?
Beaglehole and Magnus
Int J Epidemiol 2002;31:1117-1122.
ABSTRACT
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Commentary: Lifelong prevention of atherosclerosis: the critical importance of major risk factor exposures
Greenland et al.
Int J Epidemiol 2002;31:1129-1134.
FULL TEXT
Response: Coronary heart disease prevention: act now, research at leisure
Beaglehole and Magnus
Int J Epidemiol 2002;31:1134-1135.
FULL TEXT
Effect of Blood Pressure Lowering and Antihypertensive Drug Class on Progression of Hypertensive Kidney Disease: Results From the AASK Trial
Wright et al.
JAMA 2002;288:2421-2431.
ABSTRACT
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Primary Prevention of Hypertension: Clinical and Public Health Advisory From the National High Blood Pressure Education Program
Whelton et al.
JAMA 2002;288:1882-1888.
ABSTRACT
| FULL TEXT
Task Force #1--magnitude of the prevention problem: opportunities and challenges
Benjamin et al.
J Am Coll Cardiol 2002;40:588-603.
FULL TEXT
contribution of major cardiovascular risk factors to familial premature coronary artery disease: The GENECARD project
Jomini et al.
J Am Coll Cardiol 2002;40:676-684.
ABSTRACT
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AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke: 2002 Update: Consensus Panel Guide to Comprehensive Risk Reduction for Adult Patients Without Coronary or Other Atherosclerotic Vascular Diseases
Pearson et al.
Circulation 2002;106:388-391.
FULL TEXT
Eight-Year Blood Pressure Change in Middle-Aged Men: Relationship to Multiple Nutrients
Stamler et al.
Hypertension 2002;39:1000-1006.
ABSTRACT
| FULL TEXT
Invited Commentary: Height-Cardiovascular Disease Relation: Where to Go from Here?
Miura et al.
Am J Epidemiol 2002;155:688-689.
FULL TEXT
Screening for traditional risk factors for cardiovascular disease: A review for oral health care providers
GLICK
Journal of the American Dental Association 2002;133:291-300.
ABSTRACT
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Prevention of Coronary Heart Disease by Diet and Lifestyle: Evidence From Prospective Cross-Cultural, Cohort, and Intervention Studies
Kromhout et al.
Circulation 2002;105:893-898.
FULL TEXT
Stroke: The Next 30 Years
Hachinski
Stroke 2002;33:1-4.
FULL TEXT
The Real Contribution of the Major Risk Factors to the Coronary Epidemics: Time to End the "Only-50%" Myth
Magnus and Beaglehole
Arch Intern Med 2001;161:2657-2660.
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