 |
|
Depression, Hopelessness, and Desire for Hastened Death in Terminally Ill Patients With Cancer
William Breitbart, MD;
Barry Rosenfeld, PhD;
Hayley Pessin, MA;
Monique Kaim, PhD;
Julie Funesti-Esch, RN;
Michele Galietta, MA;
Christian J. Nelson, MA;
Robert Brescia, MD
JAMA. 2000;284:2907-2911.
ABSTRACT
| |
Context Understanding why some terminally ill patients desire a hastened death has become an important issue in palliative care and the debate regarding legalization of assisted suicide.
Objectives To assess the prevalence of desire for hastened death among terminally ill cancer patients and to identify factors corresponding to desire for hastened death.
Design Prospective survey conducted in a 200-bed palliative care hospital in New York, NY.
Patients Ninety-two terminally ill cancer patients (60% female; 70% white; mean age, 65.9 years) admitted between June 1998 and January 1999 for end-of-life care who passed a cognitive screening test and provided sufficient data to permit analysis.
Main Outcome Measure Scores on the Schedule of Attitudes Toward Hastened Death (SAHD), a self-report measure assessing desire for hastened death among individuals with life-threatening medical illness.
Results Sixteen patients (17%) were classified as having a high desire for hastened death based on the SAHD and 15 (16%) of 89 patients met criteria for a current major depressive episode. Desire for hastened death was significantly associated with a clinical diagnosis of depression (P = .001) as well as with measures of depressive symptom severity (P<.001) and hopelessness (P<.001). In multivariate analyses, depression (P = .003) and hopelessness (P<.001) provided independent and unique contributions to the prediction of desire for hastened death, while social support (P = .05) and physical functioning (P = .02) added significant but smaller contributions.
Conclusions Desire for hastened death among terminally ill cancer patients is not uncommon. Depression and hopelessness are the strongest predictors of desire for hastened death in this population and provide independent and unique contributions. Interventions addressing depression, hopelessness, and social support appear to be important aspects of adequate palliative care, particularly as it relates to desire for hastened death.
INTRODUCTION
Understanding why some patients with a terminal illness seek to hasten their death remains an important element in both the physician-assisted suicide debate as well as the practice of palliative care.1-3 Conflicting findings regarding the importance of factors such as pain, depression, and physical functioning have fueled debates regarding how best to respond to patient expressions of a desire to die.4-5
Unfortunately, the growing literature on interest in physician-assisted suicide has been plagued by methodological shortcomings that limit the conclusiveness of published findings.6 In response to methodological concerns, researchers have identified the concept of "desire for hastened death" as a unifying construct underlying requests for assisted suicide, euthanasia, and suicidal thoughts in general.7-9 Studying desire for death may be preferable to studying requests for assisted suicide because the latter are influenced by legal and social constraints as well as desire for hastened death. Studying factors associated with desire for hastened death enables researchers to explore issues central to end-of-life care in a broad spectrum of terminally ill individuals rather than the minority who request assisted suicide.
Recently, researchers have developed scales designed to assess the construct of desire for hastened death.8-10 Chochinov et al8 developed the first such scale, a clinician-rated single-item scale, the Desire for Death Rating Scale. More recently, Rosenfeld et al9-10 published a 20-item self-report measure of desire for hastened death for use with medically ill patients, the Schedule of Attitudes Toward Hastened Death (SAHD). Both of these measures assess the extent to which medically ill individuals desire a more rapid death than would occur naturally. In our study, we used the SAHD to assess the factors influencing desire for hastened death among hospitalized, terminally ill cancer patients. The purpose of this investigation was to explore the relationships between desire for hastened death and depression, hopelessness, social support, and physical symptoms to improve end-of-life care.
METHODS
Patients
Patients were recruited after admission to a 200-bed palliative care hospital in New York City between June 1, 1998, and January 31, 1999. Patients had a life expectancy of less than 6 months and the average time until death was 28 days. Patients were eligible for study participation if they spoke English, were sufficiently cognitively intact to provide informed consent and valid data, and were not considered likely (by their physician) to suffer psychological harm from participation. Patients approached for participation represented 22% of the total patients admitted during the study period (most patients admitted were too cognitively impaired or ill to participate in research). Prior to participation, all patients were informed of the nature, risks, and benefits of study participation and consented to participate. The study was approved by the Calvary Hospital institutional review board.
Of 154 patients offered participation, 122 consented (79%; most patients who refused cited physical discomfort and/or fatigue as the reason). An additional 22 patients were excluded because their Mini-Mental State Examination score11 was below 20, resulting in a sample of 100 patients who met inclusion and exclusion criteria. Only 92 of these 100 patients provided sufficient data to permit data analysis (80 subjects completed the entire battery). Eight patients were unable to complete the study because of physical deterioration or death; 3 patients withdrew because of psychological distress, and 7 withdrew for other reasons (eg, increased confusion, family member request). The data presented herein are based on the 92 patients who provided sufficient data to permit most statistical analyses.
The sample included 55 women and 37 men (Table 1), with an average age of 65.9 years (SD = 15.6) and an average of 12.7 years of education (SD = 3.7). Most patients were white (70%); 21% were African American, and 9% were Hispanic. The demographic composition of the sample was roughly comparable to the overall composition of patients hospitalized during the study period (female, 54%; average age, 70.2 years; white, 60%; African American, 24%; Hispanic, 13%; and other, 2%). Fifty-two percent of the sample was Catholic, with 18% Protestant, 16% Jewish, and 13% other (or no) religious affiliation. Seventy-eight percent of the sample (63 of 81, data were missing for 11 subjects) reported pain during the preceding 2 weeks; the average pain intensity (based on a 0-10 rating scale) for these patients was 4.3 (SD = 2.1), reflecting mild to moderate pain. At the time of study participation, 37 (40%) of 92 were prescribed antidepressants, although these medications were occasionally prescribed for pain.
|
|
|
|
Table 1. Subject Characteristics
|
|
|
Procedures
Participants who consented to participate and scored 20 or higher on the Mini-Mental State Examination were administered several clinician-rated and self-report measures (because of potential fatigue or vision problems, all questionnaires were read to participants). Most evaluations were completed in a single interview, although testing was occasionally divided into 2 sessions conducted over the next few days (incomplete data were retained whenever possible, providing patients had completed the SAHD and most of the relevant measures; because the order of administration was varied, missing data are not likely to be systematically biased).
The measures administered included the following: the SAHD,9-10 the Structured Clinical Interview for DSM-IV [Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition] (SCID),12 the Hamilton Depression Rating Scale (HDRS),13 the Beck Hopelessness Scale (BHS),14 the Duke-University of North Carolina Functional Social Support Questionnaire (FSSQ),15 the Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being Scale,16 the Brief Pain Inventory,17 the Memorial Symptom Assessment Scale,18 the Karnofsky Performance Rating Scale (KPRS),19 and an abbreviated version of the McGill Quality of Life Questionnaire.20 Assessments were conducted jointly by 2 investigators to establish reliability. Demographic and medical data were elicited from subjects and hospital charts. Patients diagnosed with major depression (based on SCID interviews) were referred to the institution's psychiatrist for further evaluation and treatment.
Statistical Analysis
Because the distribution of SAHD scores was skewed, nonparametric statistics were used for most analyses. Spearman correlation coefficients were used to quantify the association between SAHD scores and independent variables (eg, HDRS, BHS), and Kruskal-Wallis tests were used to assess whether SAHD scores differed across sex, race, and other categorical variables. Interrater reliability was assessed using intraclass correlation coefficients for the HDRS and KPRS and  coefficients for SCID diagnosis. The reliability coefficients were as follows: HDRS, 0.80; KPRS, 0.76; and SCID, 0.55.
RESULTS
Prevalence of Depression and Desire for Death
Based on SCID interviews, 15 (17%) of 89 patients met DSM-IV criteria for a major depressive episode (SCID interviews could not be completed for 3 subjects). The average HDRS score for this sample was 10.8 (SD = 6.4; range, 0-27), indicating moderate depressive symptoms. The average number of items endorsed on the BHS was 8.5 (SD = 6.4; range, 0-20), indicating a moderately high level of pessimism. Interestingly, patients who met the criteria for a diagnosis of major depression (based on SCID interviews) did not differ from nondepressed patients on the BHS (10.3 vs 8.2, t = 1.6, P = .12). Further, depression and hopelessness scores (HDRS and BHS, respectively) were only moderately, although significantly, correlated (r = 0.29, P<.008).
The average total score on the SAHD for this sample of terminally ill cancer patients was 4.76 (SD = 4.3; range, 0-16; maximum possible range, 0-20). As expected, the distribution of SAHD total scores was positively skewed, with more than 55% (51 of 92) endorsing 3 or fewer items. Based on prior SAHD validation studies, we used a cutoff score of 10 to identify patients with a "high" desire for hastened death. Using this cutoff, 16 (17%) of 92 patients studied indicated a high desire for hastened death.
Desire for Hastened Death, Depression, and Hopelessness
A SCID diagnosis of depression was significantly associated with desire for hastened death ( 21 = 11.44, P = .001). Of 15 patients who met criteria for a major depressive episode, 7 (47%) were classified as having a high desire for hastened death and 8 (53%) were not. Conversely, among the 74 patients who were not depressed, 9 (12%) had a high desire for hastened death while 65 (88%) did not. Thus, patients with a major depression were 4 times more likely to have high desire for hastened death (47% vs 12%). Likewise, mean SAHD scores for patients with a major depression were 8.9 (SD = 5.4) compared with 3.9 (SD = 3.6) for nondepressed patients (Kruskal-Wallis 21 = 11.17, P<.001). Patients classified as having a high desire for hastened death also obtained significantly higher scores on the HDRS than patients with low desire for hastened death (16.7 vs 9.6, t85 = 4.20, P<.001) and endorsed significantly more items on the BHS (13.6 vs 7.5, t84 = 5.58, P<.001). There was a significant correlation between SAHD total scores and scores on both the HDRS and BHS (r = 0.49, P<.001 and r = 0.54, P<.001, respectively), with more depressed and hopeless patients endorsing more SAHD items.
Finally, using a 2-way analysis of variance we examined the role of hopelessness, in addition to depression, in predicting a desire for hastened death. Patients who endorsed more than 8 items on the BHS were classified as "hopeless" and compared with patients who endorsed 8 or fewer items. This analysis, which accounted for 37% of the variance in SAHD scores, revealed significant main effects for both depression and hopelessness (F = 9.33, P = .003 and F = 15.16, P<.001, respectively), but no interaction effect (F = 0.07, P = .96). This analysis indicates that both depression and hopelessness provide independent contributions to predicting desire for hastened death. Table 2 displays the relationships among depression, hopelessness, and desire for hastened death, demonstrating that patients with neither depression (based on the SCID) nor hopelessness had low levels of desire for hastened death. The presence of either of these factors increased desire for hastened death somewhat, while the presence of both depression and hopelessness increased desire for hastened death considerably.
|
|
|
|
Table 2. Relationships Among Depression, Hopelessness, and Desire for Hastened Death*
|
|
|
Additional Factors Influencing Desire for Hastened Death
A stepwise multiple regression analysis was conducted to identify the strongest predictors of desire for hastened death. This analysis resulted in a significant model that accounted for more than 51% of the variance in SAHD scores (F = 18.79, P<.001). The variables remaining in this model were hopelessness (partial F = 29.77, P<.001) and depression (partial F = 13.94, P<.001), as well as overall physical functioning (KPRS: partial F = 5.77, P = .02) and social support (FSSQ: partial F = 4.35, P = .05). With these 4 variables included in the model, no other clinical or demographic variables contributed significantly to the prediction of SAHD scores. Of note, these findings were comparable when data were analyzed only for the subset of patients who reported pain.
The univariate correlations between SAHD scores and the independent variables studied are reported in Table 3. Of the demographic variables measured, only race was significantly associated with desire for death (whites endorsed significantly more SAHD items than nonwhites, 5.5 vs 3.1, Kruskal-Wallis 21 = 8.03, P = .004). The strongest correlates of desire for hastened death were measures of spiritual well-being and quality of life (both negatively correlated with SAHD scores) and the perception of being a burden to others, physical symptoms, and symptom distress (all of which were positively correlated with SAHD scores). There was no significant association between desire for hastened death and pain (Kruskal-Wallis 21 = 0.11, P = .75) or pain intensity "on average" for patients who reported pain (r = 0.16, P = .20), nor with perceived quality of social support (r = -0.06, P = .64). Of note, there were few differences when these correlations were recalculated for only those patients who did not meet the criteria for a major depressive episode (Table 3).
|
|
|
|
Table 3. Correlates of Desire for Death (Schedule of Attitudes Toward Hastened Death Total Scores)*
|
|
|
COMMENT
In a sample of terminally ill cancer patients receiving aggressive, inpatient palliative care, we found substantial rates of clinical depression (17%) and desire for hastened death (17%). Depressed patients were 4 times more likely to have high desire for hastened death compared with nondepressed patients (47% vs 12%). Hopelessness (characterized as a pessimistic cognitive style rather than an assessment of one's poor prognosis) also appears to be an integral determinant of desire for hastened death. We found that both depression and hopelessness provided independent contributions to predicting desire for hastened death. Among patients who were neither depressed nor hopeless, none had high desire for hastened death, whereas approximately one fourth of the patients with either one of these factors had high desire for hastened death, and nearly two thirds of patients with both depression and hopelessness had high desire for hastened death.
We also found a number of social, physical, and psychological variables associated with desire for hastened death, including spiritual well-being, quality of life, physical symptoms, symptom distress, physical functioning, and perception of oneself as a burden to others. However, we found no significant association between desire for hastened death and either the presence of pain or pain intensity. This finding may reflect the quality of pain management practiced by the study institution (average pain intensity was <5, corresponding to relatively good physical functioning and quality of life).21 Alternatively, these results may simply confirm previous research that found little or no relationship between pain and desire for hastened death or interest in assisted suicide.8, 22-23
Our finding, that both depression and hopelessness provide independent contributions to desire for hastened death, is perhaps the most novel and clinically relevant contribution of these data. Chochinov et al8 found a strong association between desire for hastened death and clinical depression in terminally ill patients with cancer (58% of their patients with high desire for hastened death were diagnosed with a major depression compared with 44% in our sample), but that study did not include a measure of hopelessness. In a subsequent analysis, Chochinov and colleagues24 found significant associations between depression, hopelessness, and suicidal ideation (rather than desire for death), concluding that "the correlation of depression with suicidal ideation is based largely on variance that it shares with hopelessness." Ganzini et al25 found that hopelessness was significantly associated with "interest in physician assisted suicide" among patients with amyotrophic lateral sclerosis while depression was not, but this study used responses to hypothetical questions regarding interest in assisted suicide rather than a measure of desire for hastened death and used a measure of depression that did not generate a clinical diagnosis.
Disentangling the constructs of depression and hopelessness is particularly difficult in the context of terminal illnesses. Because terminal illness is by definition incurable, many individuals might confuse a "hopeless" prognosis with a "hopeless" cognitive style. Our experience and these data suggest that patients often maintain hope during the final weeks of life, although what they hope for may evolve as death nears. Indeed, less than half of our sample endorsed a large number of items on the BHS, a measure of pessimism. Further, because hopelessness can be a symptom of depression, these 2 constructs are often assumed to be more overlapping than may be justified. We found only a modest correlation between these 2 measures (r = 0.29), indicating that depression and hopelessness are distinct constructs.
The data and conclusions described here are tempered by methodological limitations. First, although we measured desire for hastened death, we cannot determine which, if any, of these patients would have requested assisted suicide if this option were legal. A related concern is whether the SAHD can differentiate individuals who have "accepted" death from those who desire a hastened death. While some SAHD items might be endorsed by those who accept their death yet do not want to hasten death, most items assess interest in hastening death. By analyzing these data using a cutoff score to reflect a high desire for hastened death, the likelihood of confusing "acceptance" of death with desire for hastened death is thereby minimized. Another methodological issue concerns the generalizability of our findings, as our sample was recruited from a state-of-the-art palliative care facility. This sample represents an ethnically and economically diverse group that is likely representative of terminally ill cancer patients receiving high-quality palliative care. It is possible that the prevalence of desire for hastened death and depression would be even greater in patients receiving less adequate palliative care.
Because depression and hopelessness are not identical, clinical interventions may need to target these issues selectively. There is a general consensus that individuals with a major depression can be effectively treated, even in the context of terminal illness, but no research has addressed whether such treatment influences desire for hastened death.26-28 A more challenging question is how to address hopelessness, in the absence of depressive illness, among terminally ill patients. Interventions to address hopelessness have not been systematically studied and represent an important new frontier in palliative care. Psychotherapeutic interventions such as cognitive behavioral therapy targeting pessimistic cognitions or spirituality-based interventions to address existential issues such as a loss of meaning may help decrease hopelessness.27-29 Further research regarding the impact of treatments for depression and/or hopelessness on desire for hastened death is needed to formulate appropriate clinical responses to patients who express a desire for hastened death.
AUTHOR INFORMATION
Funding/Support: This research was supported by the Faculty Scholar's Program, Open Society Institute Project on Death in America (Dr Breitbart, scholar). Additional support was provided by the Emily Davie and Joseph S. Kornfeld Foundation and the philanthropy of Jack and Sarah Rudin.
Corresponding Author: William Breitbart, MD, Department of Psychiatry and Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, 1242 Second Ave, New York, NY 10021 (e-mail: breitbaw{at}mskcc.org).
Author Affiliations: Department of Psychiatry and Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, New York, NY (Drs Breitbart and Kaim, Mss Pessin and Funesti-Esch, and Mr Nelson); Department of Psychology, Fordham University, Bronx, NY (Dr Rosenfeld and Ms Galietta); and the Palliative Care Institute, Calvary Hospital, Bronx, NY (Dr Brescia).
REFERENCES
| |
1. Ganzini L, Nelson HD, Schmidt TA, et al. Physician's experiences with the Oregon Death With Dignity Act. N Engl J Med. 2000;342:557-563.
FREE FULL TEXT
2. Sullivan AD, Hedberg K, Fleming DA. Legalized physician-assisted suicide in Oregon—the second year. N Engl J Med. 2000;342:598-604.
FREE FULL TEXT
3. Meier DE, Emmons C-A, Wallenstein S, et al. A national survey of physician-assisted suicide and euthanasia in the United States. N Engl J Med. 1998;338:1193-1201.
FREE FULL TEXT
4. Foley KM. Competent care for the dying instead of physician-assisted suicide. N Engl J Med. 1997;336:54-58.
FULL TEXT
|
ISI
| PUBMED
5. Hendin H, Klerman G. Physician-assisted suicide: the dangers of legalization. Am J Psychiatry. 1993;150:143-145.
FREE FULL TEXT
6. Rosenfeld B. Depression, assisted suicide and the right to die. Psychol Public Policy Law. In press.
7. Brown JH, Henteleff P, Barakat S, Rowe CJ. Is it normal for terminally ill patients to desire death? Am J Psychiatry. 1986;143:208-211.
FREE FULL TEXT
8. Chochinov HM, Wilson KG, Enns M, et al. Desire for death in the terminally ill. Am J Psychiatry. 1995;152:1185-1191.
FREE FULL TEXT
9. Rosenfeld B, Breitbart W, Stein K, et al. Measuring desire for death among patients with HIV/AIDS: the Schedule of Attitudes Toward Hastened Death. Am J Psychiatry. 1999;156:94-100.
FREE FULL TEXT
10. Rosenfeld B, Breitbart W, Galietta M, et al. The Schedule of Attitudes Toward Hastened Death: measuring desire for death in terminally ill cancer patients. Cancer. 2000;88:2868-2875.
FULL TEXT
|
ISI
| PUBMED
11. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state": a practical method of grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189-198.
FULL TEXT
|
ISI
| PUBMED
12. Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders-Nonpatient Edition (SCID-NP) Version 2.0. New York, NY: Biometrics Research Department, New York State Psychiatric Institute; 1996.
13. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:56-61.
ISI
| PUBMED
14. Beck AT, Weissman A, Lester D, et al. The measurement of pessimism: the Beck Hopelessness Scale. J Consult Clin Psychol. 1974;42:861-865.
FULL TEXT
|
ISI
| PUBMED
15. Broadhead WE, Gehlbach SH, De Gruy FV, et al. The Duke-UNC Functional Social Support Questionnaire: measurement of social support in family medicine patients. Med Care. 1988;26:709-723.
ISI
| PUBMED
16. Brady MJ, Peterman AH, Fitchett G, et al. A case for including spirituality in quality of life measurement in oncology. Psychooncology. 1999;8:417-428.
FULL TEXT
| PUBMED
17. Cleeland CS. Measurement of pain by subjective report. In: Chapman CR, Loeser JD, eds. Advances in Pain Research and Therapy, XXII: Issues of Pain Measurement. New York, NY: Raven Press; 1989:391-403.
18. Portenoy R, Thaler HT, Kornblith AB, et al. The Memorial Symptom Assessment Scale: an instrument for evaluation of symptom prevalence, characteristics and distress. Eur J Cancer. 1994;30A:1326-1336.
19. Karnofsky DA, Burchenal JH. The clinical evaluation of chemotherapeutic agents in cancer. In: MacLeod CM, ed. Evaluation of Chemotherapeutic Agents. New York, NY: Columbia University Press; 1949:191-205.
20. Cohen SR, Mount BF, Strobel MG, et al. The McGill Quality of Life Questionnaire: a measure of quality of life appropriate for people with advanced disease. Palliat Med. 1995;9:207-219.
FREE FULL TEXT
21. Serlin RC, Mendoza TR, Nakamura Y, et al. When is cancer pain mild, moderate or severe? grading pain severity by its interference with function. Pain. 1995;61:277-284.
FULL TEXT
|
ISI
| PUBMED
22. Breitbart W, Rosenfeld B, Passik S. Interest in physician assisted suicide among ambulatory HIV-infected patients. Am J Psychiatry. 1996;153:238-242.
FREE FULL TEXT
23. Emanuel EJ, Fairclough DL, Daniels ER, Clarridge BR. Euthanasia and physician assisted suicide: attitudes and experiences of oncology patients, oncologists, and the public. Lancet. 1996;347:1805-1810.
FULL TEXT
|
ISI
| PUBMED
24. Chochinov HM, Wilson KG, Enns M, Lander S. Depression, hopelessness, and suicidal ideation. Psychosomatics. 1998;39:366-370.
FREE FULL TEXT
25. Ganzini L, Johnston WS, McFarland BH, et al. Attitudes of patients with amyotrophic lateral sclerosis and their care givers toward assisted suicide. N Engl J Med. 1998;339:967-973.
FREE FULL TEXT
26. Block SD. Assessing and managing depression in the terminally ill patient. Ann Intern Med. 2000;132:209-218.
FREE FULL TEXT
27. Moorey S, Greer S, Bliss J, Law M. A comparison of adjuvant psychosocial therapy and supporting counseling in patients with cancer. Psychooncology. 1998;7:218-228.
FULL TEXT
| PUBMED
28. Spiegel D. Essentials of psychotherapy intervention for cancer patients. Support Care Cancer. 1995;3:252-256.
ISI
| PUBMED
29. Rousseau P. Spirituality and the dying patient. J Clin Oncol. 2000;18:2000-2002.
FREE FULL TEXT
RELATED LETTER
Dignity-Conserving Care at the End of Life
Faye Girsh and Harvey Max Chochinov
JAMA. 2002;288(2):162.
EXTRACT
| FULL TEXT
RELATED ARTICLE
December 13, 2000
JAMA. 2000;284(22):2947-2948.
EXTRACT
| FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Evidence-Based Recommendations for Cancer Fatigue, Anorexia, Depression, and Dyspnea
Dy et al.
JCO 2008;26:3886-3895.
ABSTRACT
| FULL TEXT
Revisiting depression in palliative care settings: the need to focus on clinical utility over validity
Reeve et al.
Palliat Med 2008;22:383-391.
ABSTRACT
Depression After Diagnosis of Advanced Non-Small Cell Lung Cancer and Survival: A Pilot Study
Pirl et al.
Psychosomatics 2008;49:218-224.
ABSTRACT
| FULL TEXT
The experience of hopelessness in a population of Greek cancer patients receiving palliative care.
Mystakidou et al.
International Journal of Social Psychiatry 2008;54:262-271.
ABSTRACT
Requestioning depression in patients with cancer: Contribution of somatic and affective symptoms to Beck's Depression Inventory
Wedding et al.
Ann Oncol 2007;18:1875-1881.
ABSTRACT
| FULL TEXT
Attitudes toward euthanasia among Swedish medical students
Karlsson et al.
Palliat Med 2007;21:615-622.
ABSTRACT
Suicide-associated comorbidity among US males and females: a multiple cause-of-death analysis
Rockett et al.
Inj. Prev. 2007;13:311-315.
ABSTRACT
| FULL TEXT
Palliative Care Consultation, Quality-of-Life Measurements, and Bereavement for End-of-Life Care in Patients With Lung Cancer: ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition)
Griffin et al.
Chest 2007;132:404S-422S.
ABSTRACT
| FULL TEXT
Brain-computer interfaces: communication and restoration of movement in paralysis
Birbaumer and Cohen
J. Physiol. 2007;579:621-636.
ABSTRACT
| FULL TEXT
Feeling like a burden to others: a systematic review focusing on the end of life
McPherson et al.
Palliat Med 2007;21:115-128.
ABSTRACT
End-of-Life Care: Issues Relevant to the Geriatric Psychiatrist
Lyness
Focus 2007;5:459-471.
ABSTRACT
| FULL TEXT
Desire for Hastened Death Among Patients With Advanced AIDS
Rosenfeld et al.
Psychosomatics 2006;47:504-512.
ABSTRACT
| FULL TEXT
Suicidal Ideation and Attempts in Adult Survivors of Childhood Cancer
Recklitis et al.
JCO 2006;24:3852-3857.
ABSTRACT
| FULL TEXT
Dying, Dignity, and New Horizons in Palliative End-of-Life Care.
Chochinov
CA Cancer J Clin 2006;56:84-103.
ABSTRACT
| FULL TEXT
Review of measurement instruments in clinical and research ethics, 1999-2003.
Redman
J. Med. Ethics 2006;32:153-156.
ABSTRACT
| FULL TEXT
Differences between terminally ill cancer patients who died after euthanasia had been performed and terminally ill cancer patients who did not request euthanasia
Georges et al.
Palliat Med 2005;19:578-586.
ABSTRACT
Euthanasia and Depression: A Prospective Cohort Study Among Terminally Ill Cancer Patients
van der Lee et al.
JCO 2005;23:6607-6612.
ABSTRACT
| FULL TEXT
Depression, Euthanasia, and Improving End-of-Life Care
Emanuel
JCO 2005;23:6456-6458.
FULL TEXT
Book Review: Psychosocial Issues in Palliative Care
Barnhill
AM J HOSP PALLIAT CARE 2005;22:397-398.
July 12 Highlights and Commentary: ALS, depression, and desire for a hastened death: (How) are they related?
Neurology 2005;65:1-1.
FULL TEXT
Wish to die in end-stage ALS
Albert et al.
Neurology 2005;65:68-74.
ABSTRACT
| FULL TEXT
Existential issues do not necessarily result in existential suffering: lessons from cancer patients in Israel
Blinderman and Cherny
Palliat Med 2005;19:371-380.
ABSTRACT
Competing Paradigms of Response to Assisted Suicide Requests in Oregon
Hamilton and Hamilton
Am. J. Psychiatry 2005;162:1060-1065.
FULL TEXT
End-of-Life Care: Issues Relevant to the Geriatric Psychiatrist
Lyness
Focus 2005;3:341-353.
ABSTRACT
| FULL TEXT
The level of and relation between hope, hopelessness and fatigue in patients and family members in palliative care
Benzein and Berg
Palliat Med 2005;19:234-240.
ABSTRACT
Interpersonal processes in palliative care: an attachment perspective on the patient-clinician relationship
Tan et al.
Palliat Med 2005;19:143-150.
ABSTRACT
Understanding the Will to Live in Patients Nearing Death
Chochinov et al.
Psychosomatics 2005;46:7-10.
ABSTRACT
| FULL TEXT
A Comparative Study of Variables That Have an Impact on Noncancer End-of-Life Diagnoses
Dobratz
Clin Nurs Res 2004;13:309-325.
ABSTRACT
Decision Making at a Time of Crisis Near the End of Life
Weissman
JAMA 2004;292:1738-1743.
ABSTRACT
| FULL TEXT
End-of-Life Care: Issues Relevant to the Geriatric Psychiatrist
Lyness
AJGP 2004;12:457-472.
ABSTRACT
| FULL TEXT
Religion, Spirituality, and the Practice of Medicine
Daaleman
J Am Board Fam Med 2004;17:370-376.
ABSTRACT
| FULL TEXT
Association Between Clinician Factors and a Patient's Wish to Hasten Death: Terminally Ill Cancer Patients and Their Doctors
Kelly et al.
Psychosomatics 2004;45:311-318.
ABSTRACT
| FULL TEXT
Evidence Report on the Occurrence, Assessment, and Treatment of Depression in Cancer Patients
Pirl
J Natl Cancer Inst Monogr 2004;2004:32-39.
ABSTRACT
| FULL TEXT
Prevalence of Depression in Patients With Cancer
Massie
J Natl Cancer Inst Monogr 2004;2004:57-71.
ABSTRACT
| FULL TEXT
Major Depression, Adjustment Disorders, and Post-Traumatic Stress Disorder in Terminally Ill Cancer Patients: Associated and Predictive Factors
Akechi et al.
JCO 2004;22:1957-1965.
ABSTRACT
| FULL TEXT
The quality of medical care at the end-of-life in the USA: existing barriers and examples of process and outcome measures
Yabroff et al.
Palliat Med 2004;18:202-216.
ABSTRACT
Dignity and the Eye of the Beholder
Chochinov
JCO 2004;22:1336-1340.
FULL TEXT
Facing requests for euthanasia: a clinical practice guideline
Gastmans et al.
J. Med. Ethics 2004;30:212-217.
ABSTRACT
| FULL TEXT
Hope and Hopelessness at the End of Life
Sullivan
AJGP 2003;11:393-405.
ABSTRACT
| FULL TEXT
Allowing Patients to Die: Practical, Ethical, and Religious Concerns
Kahn et al.
JCO 2003;21:3000-3002.
FULL TEXT
Characteristics of Patients Requesting and Receiving Physician-Assisted Death
Meier et al.
Arch Intern Med 2003;163:1537-1542.
ABSTRACT
| FULL TEXT
Practical Considerations in Dialysis Withdrawal: "To Have That Option Is a Blessing"
Cohen et al.
JAMA 2003;289:2113-2119.
ABSTRACT
| FULL TEXT
Clinical Factors Associated with Suicidality in Cancer Patients
Akechi et al.
Jpn J Clin Oncol 2002;32:506-511.
ABSTRACT
| FULL TEXT
Behavioral Science and the End of Life: Introduction to the Second of Two Issues on End-of-life Care and Decisions
WERTH
American Behavioral Scientist 2002;46:323-326.
Assessing Psychological Distress Near the End of Life
PESSIN et al.
American Behavioral Scientist 2002;46:357-372.
ABSTRACT
Depression and Suicidal Ideation in Patients Who Discontinue the Life-Support Treatment of Dialysis
Cohen et al.
Psychosom. Med. 2002;64:889-896.
ABSTRACT
| FULL TEXT
Discussing Treatment Options and Risks With Medical Patients Who Have Psychiatric Problems
Ness
Arch Intern Med 2002;162:2037-2044.
FULL TEXT
Introduction: Behavioral Science and the End of Life
WERTH
American Behavioral Scientist 2002;46:195-203.
Multiple sclerosis, depression, and the risk of suicide
Caine and Schwid
Neurology 2002;59:662-663.
FULL TEXT
Experiences of Oregon Nurses and Social Workers with Hospice Patients Who Requested Assistance with Suicide
Ganzini et al.
NEJM 2002;347:582-588.
ABSTRACT
| FULL TEXT
Religion, Senescence, and Mental Health: The End of Life Is Not the End of Hope
Van Ness and Larson
AJGP 2002;10:386-397.
ABSTRACT
| FULL TEXT
Suicidal and Death Ideation in Older Primary Care Patients With Depression, Anxiety, and At-Risk Alcohol Use
Bartels et al.
AJGP 2002;10:417-427.
ABSTRACT
| FULL TEXT
Dignity-Conserving Care at the End of Life |
