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November 14, 2001
JAMA. 2001;286:2337-2338.
Physicians in the United States, Canada, and Mexico
Physicians with current and valid licenses in the United States, Canada, or Mexico who read any 3 of the selected continuing medical education (CME) articles in this issue of JAMA, complete the CME Evaluation Form, and fax it to the number or mail it to the address at the bottom of the CME Evaluation Form are eligible for category 1 CME credit. There is no charge.
The American Medical Association (AMA) is accredited by the Accreditation Council for Continuing Medical Education to sponsor CME for physicians. The AMA designates this educational activity for up to 1 hour of category 1 CME credit per JAMA issue toward the AMA Physician's Recognition Award (PRA). Each physician should claim for credit only those hours that were actually spent in this educational activity.
Physicians in Other Countries
Physicians with current and valid licenses in the United States, Mexico, or Canada are eligible for CME credit even if they live or practice in other countries. Physicians licensed in other countries are also welcome to participate in this CME activity. However, the PRA is available only to physicians licensed in the United States, Canada, or Mexico.
Earning Credit and the CME Evaluation Form
To earn credit, read 3 of the articles listed below that are designated for CME credit carefully and complete the CME Evaluation Form. The CME Evaluation Form must be submitted within 1 month of the issue date. A certificate awarding 1 hour of category 1 CME credit will be faxed or mailed to you; it is then your responsibility to maintain a record of credit received.
One of our goals is to assess continually the educational needs of our readers so we may enhance the educational effectiveness of JAMA. To achieve this goal, we need your help. You must complete the CME Evaluation Form to receive credit.
Statement of Educational Purpose
JAMA is a general medical journal. Its mission and educational purpose is to promote the science and art of medicine and the betterment of the public health. A flexible curriculum of article topics is developed annually by THE JOURNAL's editorial board and is then supplemented throughout the year with information gained from readers, authors, reviewers, and editors. To accommodate the diversity of practice types within JAMA's readership, the Reader's Choice CME activity allows readers, as adult learners, to determine their own educational needs and to assist the editors in addressing their needs in future issues.
Readers of JAMA should be able to attain the following educational objectives: (1) select and read at least 3 articles in 1 issue to gain new medical information on topics of particular interest to them as physicians, (2) assess the articles' value to them as practicing physicians, and (3) think carefully about how this new information may influence their own practices. The educational objective for each CME article is given after the article title below.
CME Articles in This Issue of JAMA
Clinical Proteomics: Personalized Molecular Medicine (SEE ARTICLE)
Educational Objective: To briefly review proteomics and its place in basic and clinical sciences.
Complete Genomic Screen in Parkinson Disease: Evidence for Multiple Genes (SEE ARTICLE)
Educational Objective: To understand that Parkinson disease may have several genetic determinants.
Association of Single-Nucleotide Polymorphisms of the Tau Gene With Late-Onset Parkinson Disease (SEE ARTICLE)
Educational Objective: To learn about a specific genetic determinant of idiopathic Parkinson disease.
Tamoxifen and Breast Cancer Incidence Among Women With Inherited Mutations in BRCA1 and BRCA2: National Surgical Adjuvant Breast and Bowel Project (NSABP-P1) Breast Cancer Prevention Trial (SEE ARTICLE)
Educational Objective: To learn about differences in the effect of tamoxifen in breast cancer incidence among women with different genetic risk factors.
Postmortem Molecular Analysis of SCN5A Defects in Sudden Infant Death Syndrome (SEE ARTICLE)
Educational Objective: To learn that one cause of sudden infant death syndrome may be a genetic mutation affecting cardiac ion channels.
Potential Role of Pharmacogenomics in Reducing Adverse Drug Reactions: A Systematic Review (SEE ARTICLE)
Educational Objective: To review the evidence that adverse drug events may be prevented by individualizing drug therapy based on patients' genetic profiles.
Gene Expression Profile Analysis by DNA Microarrays: Promise and Pitfalls (SEE ARTICLE)
Educational Objective: To understand some of the technical difficulties in performing gene expression profile analyses.
The Anatomy of the Human Genome: A Neo-Vesalian Basis for Medicine in the 21st Century (SEE ARTICLE)
Educational Objective: To review the history of medical genetics.
Implications of the Human Genome for Understanding Human Biology and Medicine (SEE ARTICLE)
Educational Objective: To understand how genomic knowledge may form the basis for scientific discovery to improve human health.
Molecular Basis of Mature T-Cell Leukemia (SEE ARTICLE)
Educational Objective: To understand genetic determinants of mature T-cell leukemia.
After reading 3 of these articles, complete the CME Evaluation Form.
RELATED ARTICLES
Clinical Proteomics: Personalized Molecular Medicine
Lance A. Liotta, Elise C. Kohn, and Emanuel F. Petricoin
JAMA. 2001;286(18):2211-2214.
EXTRACT
| FULL TEXT
Complete Genomic Screen in Parkinson Disease: Evidence for Multiple Genes
William K. Scott, Martha A. Nance, Ray L. Watts, Jean P. Hubble, William C. Koller, Kelly Lyons, Rajesh Pahwa, Matthew B. Stern, Amy Colcher, Bradley C. Hiner, Joseph Jankovic, William G. Ondo, Fred H. Allen, Jr, Christopher G. Goetz, Gary W. Small, Donna Masterman, Frank Mastaglia, Nigel G. Laing, Jeffrey M. Stajich, Brandon Slotterbeck, Michael W. Booze, Robert C. Ribble, Evadnie Rampersaud, Sandra G. West, Rachel A. Gibson, Lefkos T. Middleton, Allen D. Roses, Jonathan L. Haines, Burton L. Scott, Jeffery M. Vance, and Margaret A. Pericak-Vance
JAMA. 2001;286(18):2239-2244.
ABSTRACT
| FULL TEXT
Association of Single-Nucleotide Polymorphisms of the Tau Gene With Late-Onset Parkinson Disease
Eden R. Martin, William K. Scott, Martha A. Nance, Ray L. Watts, Jean P. Hubble, William C. Koller, Kelly Lyons, Rajesh Pahwa, Matthew B. Stern, Amy Colcher, Bradley C. Hiner, Joseph Jankovic, William G. Ondo, Fred H. Allen, Jr, Christopher G. Goetz, Gary W. Small, Donna Masterman, Frank Mastaglia, Nigel G. Laing, Jeffrey M. Stajich, Robert C. Ribble, Michael W. Booze, Allison Rogala, Michael A. Hauser, Fengyu Zhang, Rachel A. Gibson, Lefkos T. Middleton, Allen D. Roses, Jonathan L. Haines, Burton L. Scott, Margaret A. Pericak-Vance, and Jeffery M. Vance
JAMA. 2001;286(18):2245-2250.
ABSTRACT
| FULL TEXT
Tamoxifen and Breast Cancer Incidence Among Women With Inherited Mutations in BRCA1 and BRCA2: National Surgical Adjuvant Breast and Bowel Project (NSABP-P1) Breast Cancer Prevention Trial
Mary-Claire King, Sam Wieand, Kathryn Hale, Ming Lee, Tom Walsh, Kelly Owens, Jonathan Tait, Leslie Ford, Barbara K. Dunn, Joseph Costantino, Lawrence Wickerham, Norman Wolmark, and Bernard Fisher
JAMA. 2001;286(18):2251-2256.
ABSTRACT
| FULL TEXT
Postmortem Molecular Analysis of SCN5A Defects in Sudden Infant Death Syndrome
Michael J. Ackerman, Benjamin L. Siu, William Q. Sturner, David J. Tester, Carmen R. Valdivia, Jonathan C. Makielski, and Jeffrey A. Towbin
JAMA. 2001;286(18):2264-2269.
ABSTRACT
| FULL TEXT
Potential Role of Pharmacogenomics in Reducing Adverse Drug Reactions: A Systematic Review
Kathryn A. Phillips, David L. Veenstra, Eyal Oren, Jane K. Lee, and Wolfgang Sadee
JAMA. 2001;286(18):2270-2279.
ABSTRACT
| FULL TEXT
Gene Expression Profile Analysis by DNA Microarrays: Promise and Pitfalls
Hadley C. King and Animesh A. Sinha
JAMA. 2001;286(18):2280-2288.
ABSTRACT
| FULL TEXT
The Anatomy of the Human Genome: A Neo-Vesalian Basis for Medicine in the 21st Century
Victor A. McKusick
JAMA. 2001;286(18):2289-2295.
ABSTRACT
| FULL TEXT
Implications of the Human Genome for Understanding Human Biology and Medicine
G. Subramanian, Mark D. Adams, J. Craig Venter, and Samuel Broder
JAMA. 2001;286(18):2296-2307.
ABSTRACT
| FULL TEXT
Molecular Basis of Mature T-Cell Leukemia
Yuri Pekarsky, Cora Hallas, and Carlo M. Croce
JAMA. 2001;286(18):2308-2314.
ABSTRACT
| FULL TEXT
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