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JAMA. 2002;287:1735-1736.

Physicians in the United States, Canada, and Mexico
Physicians with current and valid licenses in the United States, Canada, or Mexico who read any 3 of the selected continuing medical education (CME) articles in this issue of JAMA, complete the CME Evaluation Form, and fax it to the number or mail it to the address at the bottom of the CME Evaluation Form are eligible for category 1 CME credit. There is no charge.

The American Medical Association (AMA) is accredited by the Accreditation Council for Continuing Medical Education to sponsor CME for physicians. The AMA designates this educational activity for up to 1 hour of category 1 CME credit per JAMA issue toward the AMA Physician's Recognition Award (PRA). Each physician should claim for credit only those hours that were actually spent in this educational activity.

Physicians in Other Countries
Physicians with current and valid licenses in the United States, Mexico, or Canada are eligible for CME credit even if they live or practice in other countries. Physicians licensed in other countries are also welcome to participate in this CME activity. However, the PRA is available only to physicians licensed in the United States, Canada, or Mexico.

Earning Credit and the CME Evaluation Form
To earn credit, read 3 of the articles listed below that are designated for CME credit carefully and complete the CME Evaluation Form. The CME Evaluation Form must be submitted within 1 month of the issue date. A certificate awarding 1 hour of category 1 CME credit will be faxed or mailed to you; it is then your responsibility to maintain a record of credit received.

One of our goals is to assess continually the educational needs of our readers so we may enhance the educational effectiveness of JAMA. To achieve this goal, we need your help. You must complete the CME Evaluation Form to receive credit.

Statement of Educational Purpose
JAMA is a general medical journal. Its mission and educational purpose is to promote the science and art of medicine and the betterment of the public health. A flexible curriculum of article topics is developed annually by THE JOURNAL's editorial board and is then supplemented throughout the year with information gained from readers, authors, reviewers, and editors. To accommodate the diversity of practice types within JAMA's readership, the Reader's Choice CME activity allows readers, as adult learners, to determine their own educational needs and to assist the editors in addressing their needs in future issues.

Readers of JAMA should be able to attain the following educational objectives: (1) select and read at least 3 articles in 1 issue to gain new medical information on topics of particular interest to them as physicians, (2) assess the articles' value to them as practicing physicians, and (3) think carefully about how this new information may influence their own practices. The educational objective for each CME article is given after the article title below.

CME Articles in This Issue of JAMA
Dopamine Transporter Brain Imaging to Assess the Effects of Pramipexole vs Levodopa on Parkinson Disease Progression (SEE ARTICLE)

Educational Objective: To compare the effects on dopamine neuron degeneration of 2 drugs for treatment of Parkinson disease.

-Methylacyl Coenzyme A Racemase as a Tissue Biomarker for Prostate Cancer (SEE ARTICLE)

Educational Objective: To learn about a tissue biomarker for prostate cancer.

Osteopontin as a Potential Diagnostic Biomarker for Ovarian Cancer (SEE ARTICLE)

Educational Objective: To learn that osteopontin may be a marker for ovarian cancer.

Diuretic Therapy, the -Adducin Gene Variant, and the Risk of Myocardial Infarction or Stroke in Persons With Treated Hypertension (SEE ARTICLE)

Educational Objective: To learn that cardiovascular benefits of diuretic therapy for hypertensive patients may vary by genotype.

Association Between CYP2C9 Genetic Variants and Anticoagulation-Related Outcomes During Warfarin Therapy (SEE ARTICLE)

Educational Objective: To learn that the risk of excess coagulation and bleeding for patients taking warfarin therapy may vary by genotype.

Nontypeable Haemophilus influenzae in Carriage and Disease: A Difference in IgA1 Protease Activity Levels (SEE ARTICLE)

Educational Objective: To learn that genetic coding for IgA1 protease may distinguish pathogenic bacteria from normal flora.

Effect of Leptin on Arterial Thrombosis Following Vascular Injury in Mice (SEE ARTICLE)

Educational Objective: To learn that obesity may increase the risk of arterial thrombosis by means of leptin-stimulated platelet aggregation.

Mucosal Biofilm Formation in Middle-Ear Mucosa in the Chinchilla Model of Otitis Media (SEE ARTICLE)

Educational Objective To learn that biofilm formation may play a role in chronic otitis media.

After reading 3 of these articles, complete the CME Evaluation Form.

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