 |
|
Cardiorespiratory Fitness and Adiposity as Mortality Predictors in Older Adults
Xuemei Sui, MD;
Michael J. LaMonte, PhD;
James N. Laditka, PhD;
James W. Hardin, PhD;
Nancy Chase, BS;
Steven P. Hooker, PhD;
Steven N. Blair, PED
JAMA. 2007;298(21):2507-2516.
ABSTRACT
| |
Context Although levels of physical activity and aerobic capacity decline with age and the prevalence of obesity tends to increase with age, the independent and joint associations among fitness, adiposity, and mortality in older adults have not been adequately examined.
Objective To determine the association among cardiorespiratory fitness ("fitness"), adiposity, and mortality in older adults.
Design, Setting, and Patients Cohort of 2603 adults aged 60 years or older (mean age, 64.4 [SD, 4.8] years; 19.8% women) enrolled in the Aerobics Center Longitudinal Study who completed a baseline health examination during 1979-2001. Fitness was assessed by a maximal exercise test, and adiposity was assessed by body mass index (BMI), waist circumference, and percent body fat. Low fitness was defined as the lowest fifth of the sex-specific distribution of maximal treadmill exercise test duration. The distributions of BMI, waist circumference, and percent body fat were grouped for analysis according to clinical guidelines.
Main Outcome Measure All-cause mortality through December 31, 2003.
Results There were 450 deaths during a mean follow-up of 12 years and 31 236 person-years of exposure. Death rates per 1000 person-years, adjusted for age, sex, and examination year were 13.9, 13.3, 18.3, and 31.8 across BMI groups of 18.5-24.9, 25.0-29.9, 30.0-34.9, and  35.0, respectively (P = .01 for trend); 13.3 and 18.2 for normal and high waist circumference (88 cm in women; 102 cm in men) (P = .004); 13.7 and 14.6 for normal and high percent body fat (30% in women; 25% in men) (P = .51); and 32.6, 16.6, 12.8, 12.3, and 8.1 across incremental fifths of fitness (P < .001 for trend). The association between waist circumference and mortality persisted after further adjustment for smoking, baseline health status, and BMI (P = .02) but not after additional adjustment for fitness (P = .86). Fitness predicted mortality risk after further adjustment for smoking, baseline health, and either BMI, waist circumference, or percent body fat (P < .001 for trend).
Conclusions In this study population, fitness was a significant mortality predictor in older adults, independent of overall or abdominal adiposity. Clinicians should consider the importance of preserving functional capacity by recommending regular physical activity for older individuals, normal-weight and overweight alike.
INTRODUCTION
Population aging, obesity, and physical inactivity are notable public health challenges. By 2030, 22% of the US population, or 70 million individuals, will be older than 65 years.1 Approximately 32% of Americans are obese,2 and the vast majority of US adults do not engage in regular physical activity.3 A high proportion of adults have levels of functional capacity that are low enough to increase mortality risk.4 Levels of physical activity and functional aerobic capacity each decline steadily with age,5-6 while the prevalence of obesity tends to increase with age. Total medical expenditures associated with inactivity and obesity are greatest in the older population, a fact that underscores the significant economic burden to society posed by an aging population of inactive obese individuals.7
Prospective studies provide convincing evidence that obesity and physical inactivity each can produce excess mortality risk in middle-aged adults.8-15 However, data regarding associations among obesity, physical activity, and survival in older adults are sparse and largely equivocal.16-25 Some studies,17-18,20-24 but not all,19, 25 have found that obesity-related mortality risk is reduced at older ages. Most of these studies have used body mass index (BMI) as a crude measure of adiposity.17, 19-21,25 Few studies have simultaneously examined physical activity levels and clinical measures of adiposity, such as waist circumference22-24 or percent body fat,26-27 in relation to mortality specifically in older adults.17 Cardiorespiratory fitness (hereafter referred to as "fitness") is an objective reproducible measure that reflects the functional consequences of recent physical activity habits, disease status, and genetics.28 To our knowledge, no study has been conducted on the independent and joint associations among fitness, various clinical measures of adiposity, and mortality in older women and men. We therefore examined these associations in a cohort of older adults enrolled in the Aerobics Center Longitudinal Study.
METHODS
Study Population
The present study comprised 2087 men and 516 women aged 60 years or older (mean, 64.4 [SD, 4.8] years; range, 60-100). All participants completed a baseline clinical examination during 1979-2001 at the Cooper Clinic (Dallas, Texas). Study participants came to the clinic for periodic preventive health examinations and for counseling regarding diet, exercise, and other lifestyle factors associated with increased risk of chronic disease. Many participants were referred by their employers for the examination; others were referred by their personal physicians or were self-referred.
Inclusion criteria for the current analysis required participants to have a maximal treadmill exercise test at baseline, during which they must have achieved at least 85% of their age-predicted maximal heart rate (220 minus age in years). We excluded participants with a BMI less than 18.5 (calculated as weight in kilograms divided by height in meters squared) at the baseline examination and those younger than 60 years at baseline. We classified participants by race/ethnicity based on their self-report when checking specific categories on the medical history. These categories are a standard part of the medical history, and we did not collect this information for the present report. The majority of the study participants were white, well-educated, and from middle to upper socioeconomic strata. All participants provided written informed consent to participate in the follow-up study, and the Cooper Institute institutional review board approved the study annually.
Clinical Data
Participants completed a comprehensive health evaluation that included self-reported personal and family health histories; a standardized medical examination by a physician; fasting blood levels of total cholesterol, high-density lipoprotein cholesterol, triglycerides, and glucose; and a maximal treadmill exercise test. Body mass index was calculated from measured weight and height. Percent body fat was assessed with hydrostatic weighing, the sum of 7 skin-fold measures, or both, following standardized protocols.29 Detailed description of our hydrodensitometry procedures has been published.13 Fat mass (in kilograms) was calculated as weight (in kilograms) x (percent body fat ÷ 100). Fat-free mass (FFM) (in kilograms) was calculated as weight – fat mass.13 Waist circumference was measured level with the umbilicus.
Adiposity exposure groups were based on standard clinical definitions for BMI (normal weight, 18.5-24.9; overweight, 25.0-29.9; obese class I, 30.0-34.9; and obese class II, 35.0), waist circumference (normal, <88.0 cm for women and <102.0 cm for men; indicating abdominal obesity, 88.0 cm for women and 102.0 cm for men), and percent body fat (normal, <30% for women and <25% for men; obese, 30% for women and 25% for men).30 Because there is no consensus clinical categorization for FFM, groups were based on quintiles of the FFM distribution.
Blood pressure was measured with standard auscultatory methods after the participant had been seated for 5 minutes. Systolic and diastolic blood pressures were recorded as the first and fifth Korotkof sounds, respectively. Abnormal exercise electrocardiogram (ECG) responses included rhythm and conduction disturbances and ischemic ST-T wave abnormalities, as described in detail elsewhere.31 Previously, we found 90% agreement between the ECG interpretation recorded in our database and that of a group of 3 physicians who read a random sample of 357 patient records.31 Total cholesterol levels were determined in the Cooper Clinic clinical chemistry laboratory, which participates in and meets the quality control standards of the US Centers for Disease Control and Prevention lipid standardization program.
Baseline medical conditions, such as previous myocardial infarction, stroke, hypertension, diabetes, and hypercholesterolemia, were defined as a history of physician diagnosis, measured phenotypes that met clinical thresholds for a specific condition, or, when appropriate, the combination of both methods. Smoking habits (current smoker or not) and physical activity habits (physically inactive or not) were obtained from a standardized questionnaire.
We determined fitness using a maximal treadmill exercise test and a modified Balke protocol32 as previously described.12-13,33-34 Total test time correlates highly (r 0.92) with directly measured maximal oxygen uptake in men35 and women.36 Participants were encouraged not to hold onto the treadmill handrails. The test end point was volitional exhaustion or termination by the physician for medical reasons.
Fitness was grouped for our primary analysis using quintiles of the sex-specific distribution of maximal exercise duration in the overall Aerobics Center Longitudinal Study population. In secondary analyses we grouped fitness into a binary variable, low fitness (the lowest 20%) compared with higher fitness (the remaining 80%).33 Individuals in the lowest 20% within each sex group were classified as physically unfit and all others as physically fit.33 While no consensus clinical definition of low fitness currently exists, the approach we used for defining low fitness is a standardized method in the Aerobics Center Longitudinal Study. Previous reports from that study,12-13,33-34 including an earlier report in elderly participants,37 have shown that low fitness by this definition is an independent predictor of morbidity and mortality.
To standardize interpretation of exercise test performance, maximal metabolic equivalent tasks (METs) (1 MET = 3.5 mL O2 uptake/kg per minute) were estimated based on the final treadmill speed and grade.38 Exercise durations (in minutes) for the incremental fifths of fitness categories for men were less than 7.8, 7.8-10.4, 10.5-13.0, 13.1-16.4, and greater than 16.4. The corresponding durations for women were less than 5.5, 5.5-6.9, 7.0-8.9, 9.0-11.3, and greater than 11.3. In equivalent MET values, the thresholds that defined these categories were 7.2, 8.5, 9.5, and 10.8 METs for men and 5.8, 6.7, 7.6, and 8.6 METs for women.
Mortality Surveillance
Vital status was ascertained using the National Death Index and death certificates from states in which participant deaths occurred. More than 95% of mortality follow-up is complete by these methods. Causes of death were identified using International Classification of Diseases, Ninth Revision codes before 1999, and International Classification of Diseases, Tenth Revision codes (in brackets) during 1999-2003 (cardiovascular disease, 390-449.9 [I00-I78]; coronary heart disease, 410-414, 429.2 [I20-I25]; and cancer, 140-208 [C00-C97]).
Statistical Analyses
The follow-up interval was computed from the date of a participant's baseline examination until the date of death for decedents, or until December 31, 2003, for survivors. Descriptive statistics summarized baseline characteristics by survival status and by fitness levels. Groups were compared using t tests,  2 tests, and F tests. We used the Fisher Z transformation to examine the correlations among adiposity measures and exercise duration by assessing Pearson coefficients. We used Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of mortality according to fitness, adiposity, age, smoking status, abnormal exercise ECG responses, and baseline medical condition exposure categories. Multivariate analyses included the following 6 baseline covariates: age (years), sex, examination year, current smoker, abnormal exercise ECG responses, and chronic medical conditions (cardiovascular disease [myocardial infarction or stroke], hypertension, diabetes, or hypercholesterolemia). The proportional hazards assumption was examined by comparing the cumulative hazard plots grouped on exposure; no appreciable violations were noted.
Tests of linear trends in mortality rates and risk estimates across exposure categories were computed using ordinal scoring for fitness, FFM, and age groups. Models including BMI also were fitted with BMI squared to assess nonlinearity. We also examined associations between specific causes of death and fitness, BMI, waist circumference, percent body fat, and FFM. In addition, we tested joint associations of adiposity and fitness with all-cause mortality. There were no significant interactions among exposure groups.
Due to the small sample size (516) and number of deaths (52) in women, we were unable to perform a meaningful analysis in women alone. The pattern of the association between fitness, adiposity measurements, and all-cause mortality in men was similar to that observed in analyses of men and women combined. We also examined the potential interaction between sex and other covariates in the Cox regression model, and no significant interactions were observed. We therefore believe that combining women and men is an acceptable alternative. Statistical tests were 2-sided; P < .05 was accepted to indicate statistical significance.
RESULTS
Overall, the mean age of participants was 64.4 (SD, 4.8) years, and 20% of the study sample were women. There were 450 deaths during a mean follow-up of 12 years and 31 236 person-years of exposure. Participants' baseline characteristics by vital status and by fitness categories are summarized in Table 1 and Table 2. Decedents were older, had lower fitness levels, and had more cardiovascular risk factors than survivors. However, there were no significant differences in adiposity measures across vital status. Participants in the higher fitness groups were for the most part less likely to have risk factors for cardiovascular disease, such as hypertension, diabetes, or high cholesterol levels. Table 3 shows that all measures of adiposity and treadmill exercise duration were significantly correlated, except for percent body fat and FFM (r = 0.02, P = .26). Body mass index and fat mass were highly correlated, but BMI and waist circumference or percent body fat were only moderately correlated.
|
|
|
|
Table 1. Baseline Characteristics by Vital Status in 2603 Older Adults—Aerobics Center Longitudinal Study, 1979-2003
|
|
|
|
|
|
|
Table 2. Baseline Characteristics by Cardiorespiratory Fitness (Fitness) Categories in 2603 Older Adults—Aerobics Center Longitudinal Study, 1979-2003a
|
|
|
|
|
|
|
Table 3. Univariate Associations Between Adiposity Measures and Treadmill Exercise Duration in 2603 Older Adults—Aerobics Center Longitudinal Study, 1979-2003
|
|
|
Table 4 presents all-cause death rates per 1000 person-years for each exposure category, adjusted for age, sex, and examination year. Death rates were 32.6, 16.6, 12.8, 12.3, and 8.1 across incremental fifths of fitness (P < .001 for linear trend); 20.4 and 12.1 for individuals with or without abnormal exercise ECG responses, respectively (P < .001); 17.7 and 12.0 for those with or without chronic medical conditions, respectively (P < .001); and 18.2 and 13.3 for those with or without abdominal obesity, respectively (P = .004). There was a J-shaped relationship between BMI and mortality (quadratic term, P = .01). Excluding individuals who died within 2 years of follow-up did not notably alter the association between the exposures and mortality. No relationship was found between mortality risk and percent body fat or FFM.
|
|
|
|
Table 4. Risk of All-Cause Mortality Across Exposure Groups in 2603 Older Adults—Aerobics Center Longitudinal Study, 1979-2003
|
|
|
Table 5 and Table 6 show the estimated HRs and 95% CIs for fitness and adiposity exposure categories and all-cause mortality. After adjusting for age, sex, examination year, smoking, abnormal exercise ECG responses, and baseline health conditions (Table 5), HRs of mortality across incremental quintiles of fitness were 1.00, 0.53, 0.44, 0.43, and 0.30 (P <. 001 for linear trend). Additional adjustment for BMI, waist circumference, percent body fat, or FFM did not meaningfully change the results (Table 5).
|
|
|
|
Table 5. Risk of All-Cause Mortality by Cardiorespiratory Fitness (Fitness) Categories—Aerobics Center Longitudinal Study, 1979-2003
|
|
|
|
|
|
|
Table 6. Risk of All-Cause Mortality by Adiposity Measures—Aerobics Center Longitudinal Study, 1979-2003
|
|
|
When the adiposity categories were adjusted for the same set of covariates (Table 6), individuals with abdominal obesity had a higher mortality risk (HR, 1.25; 95% CI, 1.00-1.56; P = .05), although this relationship did not persist after further adjustment for fitness (HR, 0.99; 95% CI, 0.79-1.25; P = .95). The J-shaped relationship between BMI and mortality remained significant after adjusting for covariates and fitness (P = .005), although most of the interval estimates for the BMI strata are not individually significantly different from those for the reference category. There were no significant associations between mortality and percent body fat or FFM.
Also, we examined joint associations of all-cause mortality, adiposity, and fitness, for which fitness was dichotomized as unfit and fit to preserve sample size and numbers of deaths within each adiposity stratum and to provide greater clinical meaning for physicians and other health professionals working with older populations (Table 7). There were no significant interactions noted in analyses that included cross-product interaction terms for each fitness-adiposity exposure combination. Fit participants had lower death rates than unfit participants within each stratum of adiposity, except for the class I and II obesity groups. In most instances, death rates for those with higher fitness were less than half of rates for those who were unfit.
|
|
|
|
Table 7. Joint Associations of Cardiorespiratory Fitness (Fitness) and Adiposity Measures With All-Cause Mortality—Aerobics Center Longitudinal Study, 1979-2003a
|
|
|
COMMENT
The objective of this study was to evaluate relationships between mortality risk and well-defined measures of adiposity, fat distribution, and fitness in older adults. In age-, sex-, and examination year–adjusted analyses, both BMI and waist circumference were associated with mortality risk, but percent body fat and FFM were not related to mortality. The association between total mortality and waist circumference persisted after adjusting for baseline differences in age, sex, smoking, abnormal exercise ECG responses, and health status. Further adjustment for fitness eliminated the significant mortality risk associated with abdominal obesity. A J-shaped relationship between BMI and mortality remained significant after considering the influences of several covariates, including fitness.
Fitness had a strong inverse association with mortality, and this pattern of results was changed little by adjustments for adiposity or fat distribution. Thus our primary finding is that both fitness and BMI were strong and independent predictors of all-cause mortality in adults 60 years or older. Other adiposity measures either did not predict mortality (percent body fat, FFM) or did not do so in models adjusted for competing risk predictors (waist circumference).
We previously demonstrated that lower levels of fitness are strongly associated with higher risk of all-cause and cardiovascular disease mortality in younger and middle-aged men with various levels of health status.12-13,39-40 The analogous relationship is clear within adiposity subgroups.12-13 Our findings from the current study are consistent with these earlier results from the Aerobics Center Longitudinal Study and expand them to the older segment of the cohort.
Higher levels of fitness were inversely related to all-cause mortality in both normal-weight and overweight BMI subgroups, in those with a normal waist circumference and in those with abdominal obesity, and in those who have normal percent body fat and those who have excessive percent body fat (Table 7). However, obese (BMI 30.0) unfit individuals were at no higher risk for mortality when compared with obese fit individuals. The obese I and II groups had relatively small sample sizes and fewer deaths; therefore, these results must be confirmed in larger studies. In addition, we observed that fit individuals who were obese (such as those with BMI of 30.0-34.9, abdominal obesity, or excessive percent body fat) had a lower risk of all-cause mortality than did unfit, normal-weight, or lean individuals. Our data therefore suggest that fitness levels in older individuals influence the association of obesity to mortality.
Results concerning the relationship between mortality and obesity in older adults have been inconsistent. Some studies,18, 23, 25 but not all,19, 21 have suggested a lower risk of mortality in obese individuals. We found a J-shaped association between mortality and BMI calculated from measured height and weight. The age-, sex-, and examination year–adjusted mortality rate per 1000 person-years was the lowest in the overweight group and the highest in the class II obesity group (Table 4). However, the multivariate-adjusted model (without fitness) showed a nonsignificant association (HR, 0.87; 95% CI, 0.70-1.07) with overweight compared with normal-weight persons (Table 6). The fully adjusted model (including fitness) attenuated the quadratic trend (Table 6). Our findings are consistent with the report from Gale et al,26 who also found no evidence of increased mortality risk in mildly to moderately overweight women and men aged 65 or older after adjusting for self-reported physical activity.
Further joint analysis (Table 7) showed that in fit individuals the mortality risk was not significantly different across the 4 BMI categories, while in unfit individuals the mortality risk was J-shaped, with lower risk in those with BMI of 25.0-34.9 and higher risk in those with BMI of 18.5-24.9 and 35.0 or greater. These results support the hypothesis that moderate and higher fitness levels favorably influence mortality risk across categories of body composition. Normal-weight individuals in our study had greater longevity only if they were physically fit; furthermore, obese individuals who were fit did not have increased mortality.
The quadratic trend across BMI in the unfit individuals deserves further comment. In general, unfit individuals were inactive at baseline, whereas fit individuals were active. In elderly individuals, BMI is also a marker of other factors such as fitness and muscle mass; therefore, maintaining BMI at older age is an overall marker of health.17 This may be attributable to competing causes of mortality that become important factors with increasing age. It also may reflect selection factors that have allowed survival to older age.
In older populations, abdominal obesity assessed by waist circumference22-24 has been a better mortality predictor than BMI. Other indicators of adiposity, such as body fat, also have been examined for mortality associations.26-27 However, the independent association between body fat and mortality in the older population has not been adequately demonstrated.14, 27 Researchers speculate that the controversial association between adiposity and mortality in older individuals may be attributable to selective survival, cohort effects, or unadjusted confounding.41 We found that BMI or waist circumference, but not percent body fat, predicted overall mortality in adults at least 60 years old. From a practical perspective, these findings suggest that more complicated and expensive body fat measurement does not provide an advantage in assessing mortality risk over more readily available and less expensive obesity measures such as BMI or waist circumference. These findings also suggest that total adiposity per se may not be the factor that increases mortality risk among elderly individuals. Rather, fat distribution and some other factor intrinsic to BMI (eg, frame size) may underlie mortality risk in older adults. Further investigation of the effects of various measures of adiposity on mortality in other elderly populations, and on the potential role of confounding and modifying variables, would contribute usefully to this research area.
Our results also support the hypothesis that higher levels of fitness can reduce the risk of premature death12, 33, 42-43 and expand the evidence supporting this relationship in obese older persons. In a prospective cohort of 18 750 Chinese men and 37 417 Chinese women 65 or older, Schooling et al17 recently reported that self-reported physical activity was strongly associated with lower mortality in a dose-response manner. Our earlier report in older persons in the Aerobics Center Longitudinal Study also demonstrated that lower fitness, an objective measure of functional capacity that is related to recent physical activity habits, is associated with higher risk of all-cause mortality.37
However, neither our earlier report nor that by Schooling et al assessed the joint associations of physical activity, BMI, and outcomes. In the current study, we found that fitness is a strong predictor of overall death among older adults, independent of body composition and other mortality risk factors. Additional studies are needed that concurrently evaluate the joint association among objective measures of fitness or activity, body size and fatness, and longevity in the rapidly growing older population.
Increasing evidence suggests that skeletal muscle function (eg, strength, power, endurance) may contribute to improved physical functioning and longevity through biological pathways that are related to but independent of aerobic fitness.44-45 Fat-free mass was not a significant predictor of mortality risk in the present study. However, it is possible that the quality of FFM (eg, functional phenotype), rather than the absolute amount of FFM, is the key factor in determining health risk. We were unable to include in the present study an objective measure of muscle function to examine its independent and joint relationship with adiposity, fitness, and mortality risk. More data are needed to further explore the role of muscle function in successful aging and enhanced longevity among older adults.
Our study had several strengths. We used standardized and objective measurements of fitness and adiposity and examined their associations with mortality, providing quantitative risk estimates and a lower likelihood of misclassification on the exposure variables. We are unaware of any other report in which these data are available. The extensive baseline physical examination permitted systematic evaluation of the presence or absence of baseline medical conditions. The relatively long follow-up (mean, 12 years) was sufficient to accrue enough fatal end points to allow for assessing the joint association among risk factors and mortality within adiposity strata.
Limitations of the current study include a focus on participants who were primarily white and well-educated, had middle to upper socioeconomic status, and were physically able to complete a maximal exercise test. The results may not apply to other groups of older adults. However, the homogeneity of our sample strengthens the internal validity of our findings by reducing potential confounding by unmeasured factors related to socioeconomic status, such as income, education, or prestige. Residual confounding from undetected subclinical disease at baseline may exist, although it seems unlikely that it would explain all of the observed association between fitness, adiposity, and mortality, especially given the extensive medical examination performed at baseline. The primary results were not changed meaningfully when deaths in the first 2 years of follow-up were excluded. We did not have adequate information about diet or medication use to study these factors. We focused primarily on all-cause mortality because of the relatively small number of cause-specific deaths, which prevented us from stratifying cause-specific analyses by adiposity measures.
However, some exploratory analyses were performed for associations between fitness, BMI, waist circumference, percent body fat, or FFM and cause-specific mortality (data not shown). In the current study, cardiovascular disease and cancer accounted for 74% of total deaths. After adjusting for age, sex, examination year, and current smoking, fitness was significantly associated with cardiovascular disease, coronary heart disease, and cancer mortality (P < .05 for linear trend, for each). However, the associations between adiposity exposures and the above cause-specific mortality outcomes were variable. Future studies should include these important exposures and extend the analysis to these and other specific causes of death with particular interest to public health, such as stroke and diabetes mellitus. Due to a limited sample of women, who contributed relatively few deaths to the analysis, we combined women and men for analyses and adjusted the analyses for sex. In our previous reports on fitness in which we have been able to perform parallel analyses in women and men, results have generally been similar for women and men.34, 46 In this cohort we had only a single baseline assessment of fitness, adiposity measurements, and other exposures; thus, we could not examine whether changes in any of these variables occurred during follow-up and whether this may have influenced the study results.
In conclusion, in this prospective study of adults 60 years or older, low fitness predicted higher risk of all-cause mortality after adjustment for potential confounding factors, including adiposity. Fit individuals had greater longevity than unfit individuals, regardless of their body composition or fat distribution. Our data provide further evidence regarding the complex long-term relationship among fitness, body size, and survival. It may be possible to reduce all-cause death rates among older adults, including those who are obese, by promoting regular physical activity, such as brisk walking for 30 minutes or more on most days of the week (about 8 kcal/kg per week), which will keep most individuals out of the low-fitness category.43 Enhancing functional capacity also should allow older adults to achieve a healthy lifestyle and to enjoy longer life in better health.
AUTHOR INFORMATION
Corresponding Author: Xuemei Sui, MD, MPH, Department of Exercise Science, Arnold School of Public Health, University of South Carolina, 921 Assembly St, Columbia, SC 29208 (msui{at}gwm.sc.edu).
Author Contributions: Drs Sui and Blair had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Sui, LaMonte, Blair.
Acquisition of data: Sui, LaMonte, Blair.
Analysis and interpretation of data: Sui, LaMonte, Laditka, Hardin, Chase, Hooker, Blair.
Drafting of the manuscript: Sui, LaMonte, Laditka, Hardin, Chase, Hooker, Blair.
Critical revision of the manuscript for important intellectual content: Sui, LaMonte, Laditka, Hardin, Hooker, Blair.
Statistical analysis: Sui, LaMonte, Hardin.
Financial Disclosures: Dr LaMonte reported receiving book royalties (<$1000 per year) from Human Kinetics and honoraria for lectures from scientific, educational, and lay groups. Dr Blair reported receiving book royalties (<$5000 per year) from Human Kinetics; honoraria for service on the medical advisory boards of Jenny Craig, Magellan Health Services, and Matria Health Care; and honoraria for lectures from scientific, educational, and lay groups; research grants from Jenny Craig and BodyMedia Inc; and compensation as an executive lecturer for the University of North Texas. Dr Blair donates these fees to the University of South Carolina Educational Foundation or to other nonprofit groups. No other disclosures were reported.
Funding/Support: The Aerobics Center Longitudinal Study was supported by National Institutes of Health grants AG06945 and HL62508.
Role of the Sponsor: The National Institutes of Health played no role in the design and conduct of the study; the collection, management, analysis, and interpretation of data; or the preparation, review, or approval of the manuscript.
Additional Contributions: We thank the Cooper Clinic physicians and technicians for collecting the baseline data and the staff at the Cooper Institute for data entry and data management.
Author Affiliations: Departments of Exercise Science (Drs Sui, Hooker, and Blair and Ms Chase) and Epidemiology and Biostatistics (Drs Laditka, Hardin, and Blair), Center for Health Services and Policy Research (Dr Hardin), and Prevention Research Center (Dr Hooker), University of South Carolina, Columbia; Department of Social and Preventive Medicine, University at Buffalo, Buffalo, NY (Dr LaMonte); and Department of Kinesiology, Health Promotion, and Recreation, University of North Texas, Denton (Dr Blair).
REFERENCES
| |
1. Lurie N. Healthy People 2010: setting the nation's public health agenda. Acad Med. 2000;75(1):12-13.
ISI
| PUBMED
2. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA. 2006;295(13):1549-1555.
FREE FULL TEXT
3. Rosamond W, Flegal K, Friday G; et al. Heart disease and stroke statistics—2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2007;115(5):e69-e171.
FREE FULL TEXT
4. Carnethon MR, Gulati M, Greenland P. Prevalence and cardiovascular disease correlates of low cardiorespiratory fitness in adolescents and adults. JAMA. 2005;294(23):2981-2988.
FREE FULL TEXT
5. Schoenborn CA, Adams PF, Barnes PM, Vickerie JL, Schiller JS. Health behaviors of adults: United States, 1999-2001. Vital Health Stat 10. 2004(219):1-79.
PUBMED
6. Fleg JL, Morrell CH, Bos AG; et al. Accelerated longitudinal decline of aerobic capacity in healthy older adults. Circulation. 2005;112(5):674-682.
FREE FULL TEXT
7. Anderson LH, Martinson BC, Crain AL; et al. Health care charges associated with physical inactivity, overweight, and obesity. Prev Chronic Dis. 2005;2(4):A09.
PUBMED
8. National Institutes of Health. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults—the evidence report. Obes Res. 1998;6(suppl 2):51S-209S.
ISI
| PUBMED
9. Hu FB, Willett WC, Li T, Stampfer MJ, Colditz GA, Manson JE. Adiposity as compared with physical activity in predicting mortality among women. N Engl J Med. 2004;351(26):2694-2703.
FREE FULL TEXT
10. Meyer HE, Sogaard AJ, Tverdal A, Selmer RM. Body mass index and mortality: the influence of physical activity and smoking. Med Sci Sports Exerc. 2002;34(7):1065-1070.
ISI
| PUBMED
11. Hu G, Tuomilehto J, Silventoinen K, Barengo N, Jousilahti P. Joint effects of physical activity, body mass index, waist circumference and waist-to-hip ratio with the risk of cardiovascular disease among middle-aged Finnish men and women. Eur Heart J. 2004;25(24):2212-2219.
FREE FULL TEXT
12. Wei M, Kampert JB, Barlow CE; et al. Relationship between low cardiorespiratory fitness and mortality in normal-weight, overweight, and obese men. JAMA. 1999;282(16):1547-1553.
FREE FULL TEXT
13. Lee CD, Blair SN, Jackson AS. Cardiorespiratory fitness, body composition, and all-cause and cardiovascular disease mortality in men. Am J Clin Nutr. 1999;69(3):373-380.
FREE FULL TEXT
14. Katzmarzyk PT, Janssen I, Ardern CI. Physical inactivity, excess adiposity and premature mortality. Obes Rev. 2003;4(4):257-290.
FULL TEXT
| PUBMED
15. Stevens J, Cai J, Evenson KR, Thomas R. Fitness and fatness as predictors of mortality from all causes and from cardiovascular disease in men and women in the lipid research clinics study. Am J Epidemiol. 2002;156(9):832-841.
FREE FULL TEXT
16. Zamboni M, Mazzali G, Zoico E; et al. Health consequences of obesity in the elderly: a review of four unresolved questions. Int J Obes (Lond). 2005;29(9):1011-1029.
FULL TEXT
|
ISI
| PUBMED
17. Schooling CM, Lam TH, Li ZB; et al. Obesity, physical activity, and mortality in a prospective Chinese elderly cohort. Arch Intern Med. 2006;166(14):1498-1504.
FREE FULL TEXT
18. Lindqvist P, Andersson K, Sundh V, Lissner L, Bjorkelund C, Bengtsson C. Concurrent and separate effects of body mass index and waist-to-hip ratio on 24-year mortality in the Population Study of Women in Gothenburg: evidence of age-dependency. Eur J Epidemiol. 2006;21(11):789-794.
FULL TEXT
|
ISI
| PUBMED
19. Adams KF, Schatzkin A, Harris TB; et al. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N Engl J Med. 2006;355(8):763-778.
FREE FULL TEXT
20. Hjartåker A, Adami HO, Lund E, Weiderpass E. Body mass index and mortality in a prospectively studied cohort of Scandinavian women: the women's lifestyle and health cohort study. Eur J Epidemiol. 2005;20(9):747-754.
FULL TEXT
|
ISI
| PUBMED
21. Flegal KM, Graubard BI, Williamson DF, Gail MH. Excess deaths associated with underweight, overweight, and obesity. JAMA. 2005;293(15):1861-1867.
FREE FULL TEXT
22. Baik I, Ascherio A, Rimm EB; et al. Adiposity and mortality in men. Am J Epidemiol. 2000;152(3):264-271.
FREE FULL TEXT
23. Janssen I, Katzmarzyk PT, Ross R. Body mass index is inversely related to mortality in older people after adjustment for waist circumference. J Am Geriatr Soc. 2005;53(12):2112-2118.
FULL TEXT
|
ISI
| PUBMED
24. Visscher TL, Seidell JC, Molarius A, van der Kuip D, Hofman A, Witteman JC. A comparison of body mass index, waist-hip ratio and waist circumference as predictors of all-cause mortality among the elderly: the Rotterdam study. Int J Obes Relat Metab Disord. 2001;25(11):1730-1735.
FULL TEXT
|
ISI
| PUBMED
25. Folsom AR, Kushi LH, Anderson KE; et al. Associations of general and abdominal obesity with multiple health outcomes in older women: the Iowa Women's Health Study. Arch Intern Med. 2000;160(14):2117-2128.
FREE FULL TEXT
26. Gale CR, Martyn CN, Cooper C, Sayer AA. Grip strength, body composition, and mortality. Int J Epidemiol. 2007;36(1):228-235.
FREE FULL TEXT
27. Dolan CM, Kraemer H, Browner W, Ensrud K, Kelsey JL. Associations between body composition, anthropometry, and mortality in women aged 65 years and older. Am J Public Health. 2007;97(5):913-918.
FREE FULL TEXT
28. Haskell WL, Leon AS, Caspersen CJ; et al. Cardiovascular benefits and assessment of physical activity and physical fitness in adults. Med Sci Sports Exerc. 1992;24(6)(suppl):S201-S220.
ISI
| PUBMED
29. Jackson AS, Pollock ML. Generalized equations for predicting body density of men. Br J Nutr. 1978;40:497-504.
FULL TEXT
|
ISI
| PUBMED
30. Bray GA. Fat distribution and body weight. Obes Res. 1993;1(3):203-205.
PUBMED
31. Gibbons LW, Mitchell TL, Wei M, Blair SN, Cooper KH. Maximal exercise test as a predictor of risk for mortality from coronary heart disease in asymptomatic men. Am J Cardiol. 2000;86(1):53-58.
ISI
| PUBMED
32. Balke B, Ware RW. An experimental study of physical fitness in Air Force personnel. U S Armed Forces Med J. 1959;10(6):675-688.
PUBMED
33. Blair SN, Kohl HW III, Barlow CE, Paffenbarger RS Jr, Gibbons LW, Macera CA. Changes in physical fitness and all-cause mortality: a prospective study of healthy and unhealthy men. JAMA. 1995;273(14):1093-1098.
FREE FULL TEXT
34. Sui X, LaMonte MJ, Blair SN. Cardiorespiratory fitness as a predictor of nonfatal cardiovascular events in asymptomatic women and men. Am J Epidemiol. 2007;165(12):1413-1423.
FREE FULL TEXT
35. Pollock ML, Bohannon RL, Cooper KH; et al. A comparative analysis of four protocols for maximal treadmill stress testing. Am Heart J. 1976;92(1):39-46.
FULL TEXT
|
ISI
| PUBMED
36. Pollock ML, Foster C, Schmidt D, Hellman C, Linnerud AC, Ward A. Comparative analysis of physiologic responses to three different maximal graded exercise test protocols in healthy women. Am Heart J. 1982;103(3):363-373.
FULL TEXT
|
ISI
| PUBMED
37. Blair SN, Wei M. Sedentary habits, health, and function in older women and men. Am J Health Promot. 2000;15(1):1-8.
FULL TEXT
|
ISI
| PUBMED
38. American College of Sports Medicine. ACSM's Guidelines For Exercise Testing And Prescription. 7th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2005.39. Barlow CE, Kohl HW III, Gibbons LW, Blair SN. Physical fitness, mortality and obesity. Int J Obes Relat Metab Disord. 1995;19:S41-S44.
ISI
40. Church TS, Cheng YJ, Earnest CP; et al. Exercise capacity and body composition as predictors of mortality among men with diabetes. Diabetes Care. 2004;27(1):83-88.
FREE FULL TEXT
41. Elia M. Obesity in the elderly. Obes Res. 2001;9(suppl 4):244S-248S.
PUBMED
42. US Department of Health and Human Services. Physical Activity and Health: A Report of the Surgeon General. Atlanta, GA: US Dept of Health and Human Services, Centers for Disease Control and Prevention; 1996.43. Pate RR, Pratt M, Blair SN; et al. Physical activity and public health: a recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA. 1995;273(5):402-407.
FREE FULL TEXT
44. Newman AB, Kupelian V, Visser M; et al. Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort. J Gerontol A Biol Sci Med Sci. 2006;61(1):72-77.
FREE FULL TEXT
45. Sasaki H, Kasagi F, Yamada M, Fujita S. Grip strength predicts cause-specific mortality in middle-aged and elderly persons. Am J Med. 2007;120(4):337-342.
FULL TEXT
|
ISI
| PUBMED
46. Blair SN, Kampert JB, Kohl HW III; et al. Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and all-cause mortality in men and women. JAMA. 1996;276(3):205-210.
FREE FULL TEXT
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
RELATED LETTERS
Cardiorespiratory Fitness, Adiposity, and Mortality
Ming Wei
JAMA. 2008;299(9):1013.
EXTRACT
| FULL TEXT
Cardiorespiratory Fitness, Adiposity, and Mortality
Norbert Stefan, Konstantinos Kantartzis, and Hans-Ulrich Häring
JAMA. 2008;299(9):1013-1014.
EXTRACT
| FULL TEXT
Cardiorespiratory Fitness, Adiposity, and Mortality—Reply
Xuemei Sui and Steven N. Blair
JAMA. 2008;299(9):1014.
EXTRACT
| FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Role of Lifestyle and Aging on the Longitudinal Change in Cardiorespiratory Fitness
Jackson et al.
Arch Intern Med 2009;169:1781-1787.
ABSTRACT
| FULL TEXT
Randomized Controlled Trial of the Effects of Aerobic Exercise on Physical Functioning and Quality of Life in Lymphoma Patients
Courneya et al.
JCO 2009;27:4605-4612.
ABSTRACT
| FULL TEXT
Effects of leisure-time physical activity on well-being among women: a 32-year perspective
Blomstrand et al.
Scand J Public Health 2009;37:706-712.
ABSTRACT
High cardiorespiratory fitness is an independent predictor of the reduction in liver fat during a lifestyle intervention in non-alcoholic fatty liver disease
Kantartzis et al.
Gut 2009;58:1281-1288.
ABSTRACT
| FULL TEXT
The Association Between Cardiorespiratory Fitness and Risk of All-Cause Mortality Among Women With Impaired Fasting Glucose or Undiagnosed Diabetes Mellitus
Lyerly et al.
Mayo Clin Proc. 2009;84:780-786.
ABSTRACT
| FULL TEXT
Fitness and Fatness as Mortality Predictors in Healthy Older Men: The Veterans Exercise Testing Study
McAuley et al.
J Gerontol A Biol Sci Med Sci 2009;64A:695-699.
ABSTRACT
| FULL TEXT
Joint Associations of Adiposity and Physical Activity With Mortality: The National Institutes of Health-AARP Diet and Health Study
Koster et al.
Am J Epidemiol 2009;169:1344-1351.
ABSTRACT
| FULL TEXT
Clinical cardioprotection and the value of conditioning responses
Peart and Headrick
Am. J. Physiol. Heart Circ. Physiol. 2009;296:H1705-H1720.
ABSTRACT
| FULL TEXT
Associations of Cardiorespiratory Fitness and Obesity With Risks of Impaired Fasting Glucose and Type 2 Diabetes in Men
Lee et al.
Diabetes Care 2009;32:257-262.
ABSTRACT
| FULL TEXT
Effects of Exercise Modality on Insulin Resistance and Functional Limitation in Older Adults: A Randomized Controlled Trial
Davidson et al.
Arch Intern Med 2009;169:122-131.
ABSTRACT
| FULL TEXT
Effects of Exercise and Caloric Restriction on Insulin Resistance and Cardiometabolic Risk Factors in Older Obese Adults--A Randomized Clinical Trial
Yassine et al.
J Gerontol A Biol Sci Med Sci 2009;0:gln032v1-gln032.
ABSTRACT
| FULL TEXT
Letter to the Editor
Mascitelli et al.
AMERICAN JOURNAL OF LIFESTYLE MEDICINE 2009;3:74-74.
Does physical activity ameliorate the health hazards of obesity?
Lee et al.
Br. J. Sports. Med. 2009;43:49-51.
ABSTRACT
| FULL TEXT
Causes and Metabolic Consequences of Fatty Liver
Stefan et al.
Endocr. Rev. 2008;29:939-960.
ABSTRACT
| FULL TEXT
Habitual exercise and arterial aging
Seals et al.
J. Appl. Physiol. 2008;105:1323-1332.
ABSTRACT
| FULL TEXT
Association between muscular strength and mortality in men: prospective cohort study
Ruiz et al.
BMJ 2008;337:a439-a439.
ABSTRACT
| FULL TEXT
IS AGING REALLY A SOLVED PROBLEM?: Frank J. Whittington, PhD, Editor
Arking
Gerontologist 2008;48:549-553.
FULL TEXT
Update on Obesity
Bessesen
J. Clin. Endocrinol. Metab. 2008;93:2027-2034.
ABSTRACT
| FULL TEXT
Cardiorespiratory Fitness, Adiposity, and Mortality
Wei
JAMA 2008;299:1013-1013.
FULL TEXT
Cardiorespiratory Fitness, Adiposity, and Mortality
Stefan et al.
JAMA 2008;299:1013-1014.
FULL TEXT
Fitness and Mortality in Older Adults
Journal Watch Cardiology 2007;2007:3-3.
FULL TEXT
|
