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This Week in JAMA
JAMA. 2008;300(13):1489.
Adiponectin Gene Variants and Colorectal Cancer Risk
Serum levels of adiponectin, a hormone secreted by adipose tissue, are inversely associated with colorectal cancer risk and several polymorphisms of adiponectin ligand and receptor genes have been shown to influence adiponectin levels. To examine the association of adiponectin polymorphisms with colorectal cancer risk, Kaklamani and colleagues conducted 2 case-control studies involving patients with colorectal cancer and appropriate controls. In their analyses of 10 common single haplotype-tagging single nucleotide polymorphisms (SNPs) of the adiponectin (ADIPOQ) and adiponectin type 1 receptor (ADIPOR1) genes, the authors identified one ADIPOQ SNP (rs266729) that was associated with a decreased risk of colorectal cancer.
(SEE ARTICLE)
Reduced Dose of Anthrax Vaccine via IM Injection
Marano and colleagues from the Anthrax Vaccine Research Program Working Group report results from the first 1005 enrollees in a randomized clinical trial assessing the immunogenicity and safety of receiving anthrax vaccine adsorbed in a reduced dose and by intramuscular (IM) injection compared with the licensed dose regimen administered subcutaneously. The investigators found that compared with the 4-dose subcutaneous licensed regimen, the experimental 4-dose or 3-dose IM regimens were associated with noninferior immunological outcomes at 7-months' follow-up and a significantly lower occurrence of adverse events at the injection site.
(SEE ARTICLE)
Funding and Media Coverage of Medication Research
The news media are a major source of information about medical research. How the media address potential sources of bias in research—such as funding source—has received little attention. In a review of 306 news articles that reported findings from medication research published in 5 prominent medical journals and from a survey of editors of 93 widely circulated US newspapers, Hochman and colleagues found that newspaper stories often failed to mention pharmaceutical company funding and frequently referred to medications by their brand names, despite newspaper editors' contention that this was not the case.
(SEE ARTICLE)
Long-term Psychodynamic Psychotherapy
The effectiveness of long-term psychodynamic psychotherapy for patients with complex mental disorders, including personality disorders and chronic and multiple mental disorders, is not clear. In a meta-analysis of data from 11 randomized controlled trials and 12 observational studies of long-term psychodynamic psychotherapy lasting for at least a year or 50 sessions, Leichsenring and Rabung (SEE ARTICLE) found that long-term psychodynamic psychotherapy was effective and superior to shorter-term methods of psychotherapy for patients with complex mental disorders. In an editorial, Glass (SEE ARTICLE) discusses challenges in the conduct of psychotherapy research and implications for the care of patients with complex mental disorders.
CLINICIAN'S CORNER
A 60-Year-Old Woman With Mild Memory Impairment
Clinical Crossroads
Ms E, a 60-year-old semiretired and active woman, had good cognitive health until 2005 when she experienced difficulty remembering conversations and encountered an increased need to rely on written reminders. Magnetic resonance imaging of the brain revealed white matter lesions. Ellison discusses the evaluation and treatment of mild cognitive impairment.
(SEE ARTICLE)
A Piece of My Mind
"I really didn't think that I was immortal, but I thought I was close." From "The Physician in Winter."
(SEE ARTICLE)
Medical News & Perspectives
As companies market direct-to-consumer genome scans as a way for individuals to assess their future health risks, some are questioning the clinical value of these tests.
(SEE ARTICLE)
Commentaries
Right to bear arms and public health
(SEE ARTICLE)
Nosocomial infections and the Deficit Reduction Act
(SEE ARTICLE)
Reductionism and complex systems
(SEE ARTICLE)
JAMA Classics
Closed-chest cardiac massage
(SEE ARTICLE)
Editorial
JAMA's updated policy on release of information to the public.
(SEE ARTICLE)
Author in the Room Teleconference
Join Ingrid Nygaard, MD, MS, October 15 from 2 to 3 PM eastern time to discuss symptomatic pelvic floor disorders in women. To register, go to http://www.ihi.org/AuthorintheRoom.
Readers Respond
How would you manage an 82-year-old woman with hypertension and renal artery stenosis? Go to www.jama.com, read the case, and submit your response. Submission deadline is October 29.
JAMA Patient Page
For your patients: Information about mild cognitive impairment.
(SEE ARTICLE)
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