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Evidence for Safety and Efficacy Against Inhalational Anthrax

Arthur M. Friedlander, MD; Phillip R. Pittman, MD, MPH; Gerald W. Parker, DVM, PhD

JAMA. 1999;282:2104-2106.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Several countries are believed to have biological weapons programs capable of causing widespread devastating illness among unprotected individuals. Bacillus anthracis, the causative agent of anthrax, is one of the most likely pathogens to be used.¹ The decision by Secretary of Defense William S. Cohen to vaccinate the US Armed Forces against anthrax, using a licensed vaccine with which most civilian and military medical personnel were unfamiliar, prompts this review of the evidence of the safety and efficacy of the vaccine (anthrax vaccine adsorbed [AVA]).

The most common form of naturally occurring anthrax is cutaneous, acquired by direct inoculation of the organism through the skin after handling infected animal tissue or contaminated animal products. However, the form of the disease acquired as a result of a biological attack would likely be inhalational anthrax, caused by inhaling . . . [Full Text of this Article]

History of AVA

Safety of AVA

Efficacy of AVA in Humans and Animals

Efficacy Against Geographically Diverse Strains of B anthracis

Conclusion

Author Affiliations: US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Md.

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