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Use of  -Blockers and Risk of Fractures
Raymond G. Schlienger, PhD, MPH;
Marius E. Kraenzlin, MD;
Susan S. Jick, DSc;
Christoph R. Meier, PhD, MSc
JAMA. 2004;292:1326-1332.
Context Animal studies suggest that the  -blocker propranolol increases bone formation, but data on whether use of -blockers (with or without concomitant use of thiazide diuretics) is associated with reduced fracture risk in humans are limited.
Objective To determine whether use of -blockers alone or in combination with thiazides is associated with a decreased risk of fracture in adults.
Design, Setting, and Participants Case-control analysis using the UK General Practice Research Database (GPRD). The study included 30 601 case patients aged 30 to 79 years with an incident fracture diagnosis between 1993 and 1999 and 120 819 controls, matched to cases on age, sex, calendar time, and general practice attended.
Main Outcome Measures Odds ratios (ORs) of having a fracture in association with use of -blockers or a combination of -blockers with thiazides.
Results The most frequent fractures were of the hand/lower arm (n = 12 837 [42.0%]) and of the foot (n = 4627 [15.1%]). Compared with patients who did not use either -blockers or thiazide diuretics, the OR for current use of -blockers only ( 3 prescriptions) was 0.77 (95% confidence interval [CI], 0.72-0.83); for current use of thiazides only (3 prescriptions), 0.80 (95% CI, 0.74-0.86); and for combined current use of -blockers and thiazides, 0.71 (95% CI, 0.64-0.79). Data were adjusted for smoking; body mass index; number of practice visits; and use of calcium channel blockers, angiotensin-converting enzyme inhibitors, antipsychotics, antidepressants, statins, antiepileptics, benzodiazepines, corticosteroids, and estrogens.
Conclusions Our data suggest that current use of -blockers is associated with a reduced risk of fractures, taken alone as well as in combination with thiazide diuretics. Many elderly patients with hypertension who are at risk of developing osteoporosis may potentially benefit from combined therapy with -blockers and thiazides.
Author Affiliations: Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacology and Toxicology (Drs Schlienger and Meier) and Division of Endocrinology, Diabetes and Clinical Nutrition (Dr Kraenzlin), University Hospital, and Institute of Clinical Pharmacy, Department of Pharmaceutical Sciences, University of Basel (Drs Schlienger and Meier), Basel, Switzerland; and Boston Collaborative Drug Surveillance Program, Boston University, School of Medicine, Lexington, Mass (Drs Jick and Meier).
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