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  Vol. 296 No. 2, July 12, 2006 TABLE OF CONTENTS
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Daily Activity Energy Expenditure and Mortality Among Older Adults

Todd M. Manini, PhD; James E. Everhart, MD, MPH; Kushang V. Patel, PhD, MPH; Dale A. Schoeller, PhD; Lisa H. Colbert, PhD; Marjolein Visser, PhD; Frances Tylavsky, PhD; Douglas C. Bauer, MD; Bret H. Goodpaster, PhD; Tamara B. Harris, MD

JAMA. 2006;296:171-179.

Context  Exercise is associated with mortality benefits but simply expending energy through any activity in an individual's free-living environment may confer survival advantages.

Objective  To determine whether free-living activity energy expenditure is associated with all-cause mortality among older adults.

Design, Setting, and Participants  Free-living activity energy expenditure was assessed in 302 high-functioning, community-dwelling older adults (aged 70-82 years). Total energy expenditure was assessed over 2 weeks using doubly labeled water. Resting metabolic rate was measured using indirect calorimetry and the thermic effect of meals was estimated at 10% of total energy expenditure. Free-living activity energy expenditure was calculated as: (total energy expenditure x 0.90) – resting metabolic rate. Participants were followed up over a mean of 6.15 years (1998-2006).

Main Outcome Measures  Free-living activity energy expenditure (3 tertiles: low, <521 kcal/d; middle, 521-770 kcal/d; high, >770 kcal/d) and all-cause mortality.

Results  Fifty-five participants (18.2%) died during follow-up. As a continuous risk factor, an SD increase in free-living activity energy expenditure (287 kcal/d) was associated with a 32% lower risk of mortality after adjusting for age, sex, race, study site, weight, height, percentage of body fat, and sleep duration (hazard ratio, 0.68; 95% confidence interval, 0.48-0.96). Using the same adjustments, individuals in the highest tertile of free-living activity energy expenditure were at a significantly lower mortality risk compared with the lowest tertile (hazard ratio, 0.31; 95% confidence interval, 0.14-0.69). Absolute risk of death was 12.1% in the highest tertile of activity energy expenditure vs 24.7% in the lowest tertile; absolute risks were similar to these for tertiles of physical activity level. The effect of free-living activity energy expenditure changed little after further adjustment for self-rated health, education, prevalent health conditions, and smoking behavior. According to self-reports, individuals expending higher levels of free-living activity energy were more likely to work for pay (P = .004) and climb stairs (P = .01) but self-reported high-intensity exercise, walking for exercise, walking other than for exercise, volunteering, and caregiving did not differ significantly across the activity energy expenditure tertiles.

Conclusions  Objectively measured free-living activity energy expenditure was strongly associated with lower risk of mortality in healthy older adults. Simply expending energy through any activity may influence survival in older adults.


Author Affiliations: National Institute on Aging, Laboratory of Epidemiology, Demography and Biometry (Drs Manini, Patel, and Harris) and National Institute of Diabetes and Digestive and Kidney Diseases (Dr Everhart), Bethesda, Md; Departments of Nutritional Sciences (Dr Schoeller) and Kinesiology (Dr Colbert), University of Wisconsin, Madison; Institute of Health Sciences, Faculty of Earth and Life Sciences, VU University and Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, the Netherlands (Dr Visser); Department of Biostatistics and Epidemiology, University of Tennessee, Memphis (Dr Tylavsky); Department of Medicine, University of California, San Francisco (Dr Bauer); and Division of Endocrinology and Metabolism, University of Pittsburgh Medical Center, Pittsburgh, Pa (Dr Goodpaster).


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