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R. Monina Klevens, DDS, MPH; Melissa A. Morrison, MPH; Joelle Nadle, MPH; Susan Petit, MPH; Ken Gershman, MD, MPH; Susan Ray, MD; Lee H. Harrison, MD; Ruth Lynfield, MD; Ghinwa Dumyati, MD; John M. Townes, MD; Allen S. Craig, MD; Elizabeth R. Zell, MSTAT; Gregory E. Fosheim, MPH; Linda K. McDougal, MS; Roberta B. Carey, PhD; Scott K. Fridkin, MD; for the Active Bacterial Core surveillance (ABCs) MRSA Investigators

JAMA. 2007;298:1763-1771.

Context  As the epidemiology of infections with methicillin-resistant Staphylococcus aureus (MRSA) changes, accurate information on the scope and magnitude of MRSA infections in the US population is needed.

Objectives  To describe the incidence and distribution of invasive MRSA disease in 9 US communities and to estimate the burden of invasive MRSA infections in the United States in 2005.

Design and Setting  Active, population-based surveillance for invasive MRSA in 9 sites participating in the Active Bacterial Core surveillance (ABCs)/Emerging Infections Program Network from July 2004 through December 2005. Reports of MRSA were investigated and classified as either health care–associated (either hospital-onset or community-onset) or community-associated (patients without established health care risk factors for MRSA).

Main Outcome Measures  Incidence rates and estimated number of invasive MRSA infections and in-hospital deaths among patients with MRSA in the United States in 2005; interval estimates of incidence excluding 1 site that appeared to be an outlier with the highest incidence; molecular characterization of infecting strains.

Results  There were 8987 observed cases of invasive MRSA reported during the surveillance period. Most MRSA infections were health care–associated: 5250 (58.4%) were community-onset infections, 2389 (26.6%) were hospital-onset infections; 1234 (13.7%) were community-associated infections, and 114 (1.3%) could not be classified. In 2005, the standardized incidence rate of invasive MRSA was 31.8 per 100 000 (interval estimate, 24.4-35.2). Incidence rates were highest among persons 65 years and older (127.7 per 100 000; interval estimate, 92.6-156.9), blacks (66.5 per 100 000; interval estimate, 43.5-63.1), and males (37.5 per 100 000; interval estimate, 26.8-39.5). There were 1598 in-hospital deaths among patients with MRSA infection during the surveillance period. In 2005, the standardized mortality rate was 6.3 per 100 000 (interval estimate, 3.3-7.5). Molecular testing identified strains historically associated with community-associated disease outbreaks recovered from cultures in both hospital-onset and community-onset health care–associated infections in all surveillance areas.

Conclusions  Invasive MRSA infection affects certain populations disproportionately. It is a major public health problem primarily related to health care but no longer confined to intensive care units, acute care hospitals, or any health care institution.

Author Affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia (Drs Klevens, Carey, and Fridkin and Mss Morrison, Zell, and McDougal and Mr Fosheim); California Emerging Infections Program, Oakland (Ms Nadle); Connecticut Department of Health, Hartford (Ms Petit); Colorado Emerging Infections Program, Denver (Dr Gershman); Grady Memorial Hospital, Atlanta (Dr Ray); Maryland Emerging Infections Program and Johns Hopkins Bloomberg School of Public Health, Baltimore (Dr Harrison); Minnesota Department of Health, Minneapolis (Dr Lynfield); University of Rochester, Rochester General Hospital, Rochester, New York (Dr Dumyati); Oregon Health & Science University, Portland (Dr Townes); and Tennessee Department of Health, Nashville (Dr Craig).

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