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Patrick E. McBride, MD, MPH

JAMA. 2007;298:336-338.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Evidence that elevated serum triglyceride levels are associated with increased risk for atherosclerotic events is increasing. In this issue of JAMA, 2 large, long-term prospective cohort studies conducted in different populations by Bansal and colleagues¹ and by Nordestgaard and colleagues² support the role of nonfasting triglyceride levels as a significant risk factor for coronary heart disease (CHD) events. However, a high serum triglyceride level is associated with abnormal lipoprotein metabolism, as well as with other CHD risk factors including obesity, insulin resistance, diabetes mellitus, and lowered levels of high-density lipoprotein cholesterol (HDL-C).³ When determining CHD risk, how important is it to know which came first—high serum triglyceride levels or the risk factors that cause high levels?

Elevated triglyceride levels have a substantial effect on lipoprotein metabolism, which explains much of the controversy about the role of serum triglycerides as a risk factor for CHD.⁴ . . . [Full Text of this Article]

Author Affiliations: Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison.

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