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Christiane K. Kuhl, MD

JAMA. 2008;299(18):2203-2205.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The study by Berg and colleagues¹ published in this issue of JAMA addresses important clinical questions: What is the additional cancer diagnosis yield of screening ultrasound in women at increased risk of breast cancer, and what are the "costs" of such strategies in terms of false-positive diagnoses. The design of this American College of Radiology Imaging Network (ACRIN) trial, from the multi-institutional setting to source documentation and independent data analysis, is excellent from every aspect. This study and several other previously published trials^2-4 demonstrate how important it is to have institutions like ACRIN sponsor and help organize prospective clinical trials that follow good clinical practice in the world of diagnostic imaging, which, unlike clinical research in the therapeutic sector, has to proceed without the financial support and scientific infrastructure usually provided by the pharmaceutical and medical device industries.

The results of this study are impressive. Ultrasound . . . [Full Text of this Article]

Author Affiliation: Department of Radiology, University of Bonn, Bonn, Germany.

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