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Mass Antibiotic Administration for Eradication of Ocular Chlamydia trachomatis
David Mabey, DM, FRCP;
Anthony W. Solomon, MRCP, PhD
JAMA. 2008;299(7):819-821.
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Trachoma, a chronic keratoconjunctivitis caused by the bacterium Chlamydia trachomatis, is the leading infectious cause of blindness in the world. Until the 20th century it was endemic in Europe and North America, and eye hospitals established in the 19th century were founded to treat trachoma. As living standards improved, trachoma disappeared from the developed world, but it remains endemic in poor rural communities in some 55 countries, most of them in Africa and Asia. The World Health Organization (WHO) estimates suggest that more than 100 million individuals have the disease, of whom 7.6 million have potentially blinding sequelae, and 1.3 million are blind.1-2
In its early stages, mainly seen in children, trachoma causes few symptoms, but clinical signs may be observed in the conjunctiva of the everted upper eyelid, which takes on a roughened appearance due to the presence of . . . [Full Text of this Article]
Author Affiliations: Clinical Research Unit, London School of Hygiene & Tropical Medicine, London, England.
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