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Comilla Sasson, MD, MS; A. J. Hegg, MD; Michelle Macy, MD; Allison Park, MPH; Arthur Kellermann, MD, MPH; Bryan McNally, MD, MPH; for the CARES Surveillance Group

JAMA. 2008;300(12):1432-1438.

Context  Identifying patients in the out-of-hospital setting who have no realistic hope of surviving an out-of-hospital cardiac arrest could enhance utilization of scarce health care resources.

Objective  To validate 2 out-of-hospital termination-of-resuscitation rules developed by the Ontario Prehospital Life Support (OPALS) study group, one for use by responders providing basic life support (BLS) and the other for those providing advanced life support (ALS).

Design, Setting, and Patients  Retrospective cohort study using surveillance data prospectively submitted by emergency medical systems and hospitals in 8 US cities to the Cardiac Arrest Registry to Enhance Survival (CARES) between October 1, 2005, and April 30, 2008. Case patients were 7235 adults with out-of-hospital cardiac arrest; of these, 5505 met inclusion criteria.

Main Outcome Measures  Specificity and positive predictive value of each termination-of-resuscitation rule for identifying patients who likely will not survive to hospital discharge.

Results  The overall rate of survival to hospital discharge was 7.1% (n = 392). Of 2592 patients (47.1%) who met BLS criteria for termination of resuscitation efforts, only 5 (0.2%) patients survived to hospital discharge. Of 1192 patients (21.7%) who met ALS criteria, none survived to hospital discharge. The BLS rule had a specificity of 0.987 (95% confidence interval [CI], 0.970-0.996) and a positive predictive value of 0.998 (95% CI, 0.996-0.999) for predicting lack of survival. The ALS rule had a specificity of 1.000 (95% CI, 0.991-1.000) and positive predictive value of 1.000 (95% CI, 0.997-1.000) for predicting lack of survival.

Conclusion  In this validation study, the BLS and ALS termination-of-resuscitation rules performed well in identifying patients with out-of-hospital cardiac arrest who have little or no chance of survival.

Author Affiliations: Department of Emergency Medicine (Drs Sasson and Macy) and Robert Wood Johnson Clinical Scholars Program (Dr Sasson), University of Michigan, Ann Arbor; Department of Emergency Medicine/Internal Medicine, Henry Ford Health System, Detroit, Michigan (Dr Hegg); and CARES Project (Ms Park) and Department of Emergency Medicine (Drs Kellermann and McNally), Emory University, Atlanta, Georgia.

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