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The Disconnect Between Practice Guidelines and Clinical Practice—Stressed Out
George A. Diamond, MD;
Sanjay Kaul, MD
JAMA. 2008;300(15):1817-1819.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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Despite increasing evidence supporting plaque instability as the proximate cause of atherosclerotic events,1-2 treatment strategies continue to focus on the anatomic stenosis.3 This preoccupation with coronary luminology causes clinicians to perform stress tests and angiograms to identify flow-limiting lesions, even among asymptomatic patients, and to mitigate the effects of these lesions by direct mechanical or surgical intervention. As a result, clinical practice guidelines currently recommend revascularization when stress testing reveals demonstrable myocardial ischemia despite optimal medical management.3-4
Unfortunately, the guidelines are not as clear as they might be on this matter. For example, one guideline reads as follows3:
[Percutaneous coronary intervention] may be considered in patients with [Canadian Cardiovascular Society] class III angina and no evidence of ischemia on noninvasive testing or who are undergoing medical therapy and have 2- or 3-vessel [coronary artery disease] with significant proximal [left anterior descending coronary . . . [Full Text of this Article]
Author Affiliations: Division of Cardiology, Cedars-Sinai Medical Center, and the David Geffen School of Medicine, University of California, Los Angeles.
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