This Article  • Full text  • PDF  • Original Article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Topic Collections  • JAMA Classics  • Gastrointestinal Diseases  • Humanities  • History of Medicine  • Alert me on articles by topic

Commentary by Richard S. Blumberg, MD

JAMA. 2008;300(4):439-440.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

SUMMARY OF THE ORIGINAL ARTICLE

Regional Ileitis, A Pathologic and Clinical Entity

Burrill B. Crohn, MD; Leon Ginzburg, MD; Gordon D. Oppenheimer, MD

JAMA. 1932;99(6):1323-1329

This article describes, in clinical and pathologic detail, a disease of the terminal ileum characterized by a subacute or chronic necrotizing and cicatrizing inflammation. The ulceration is reported to be accompanied by a disproportionate connective tissue reaction of the involved intestinal wall, which frequently leads to stenosis of the lumen and is associated with the formation of multiple fistulas.

The disease is clinically featured by symptoms resembling those of ulcerative colitis, ie, fever, diarrhea, emaciation, and a mass in the right iliac fossa usually requiring surgical resection. The etiology is unknown.

See PDF for full text of the original JAMA article.

Author Affiliation: Harvard Medical School, Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts.