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Risk of Pancreatic Cancer in Families With Lynch Syndrome
Fay Kastrinos, MD, MPH;
Bhramar Mukherjee, PhD;
Nabihah Tayob, MS;
Fei Wang, MS;
Jennifer Sparr, MD;
Victoria M. Raymond, MS;
Prathap Bandipalliam, MD;
Elena M. Stoffel, MD, MPH;
Stephen B. Gruber, MD, MPH, PhD;
Sapna Syngal, MD, MPH
JAMA. 2009;302(16):1790-1795.
Context Lynch syndrome is an inherited cause of colorectal cancer caused by mutations of DNA mismatch repair (MMR) genes. A number of extracolonic tumors have been associated with the disorder, including pancreatic cancer; however, the risk of pancreatic cancer in Lynch syndrome is uncertain and not quantified.
Objective To estimate pancreatic cancer risk in families with germline MMR gene mutations.
Design, Setting, and Patients Cancer histories of probands and their relatives were evaluated in MMR gene mutation carriers in the familial cancer registries of the Dana-Farber Cancer Institute (n = 80), Boston, Massachusetts, and University of Michigan Comprehensive Cancer Center (n = 67), Ann Arbor, Michigan. Families enrolled before the study start date (June 2008) were eligible. Age-specific cumulative risks and hazard ratio estimates of pancreatic cancer risk were calculated and compared with the general population using modified segregation analysis, with correction for ascertainment.
Main Outcome Measures Age-specific cumulative risks and hazard ratio estimates of pancreatic cancer risk.
Results Data on 6342 individuals from 147 families with MMR gene mutations were analyzed. Thirty-one families (21.1%) reported at least 1 case of pancreatic cancer. Forty-seven pancreatic cancers were reported (21 men and 26 women), with no sex-related difference in age of diagnosis (51.5 vs 56.5 years for men and women, respectively). The cumulative risk of pancreatic cancer in these families with gene mutations was 1.31% (95% confidence interval [CI], 0.31%-2.32%) up to age 50 years and 3.68% (95% CI, 1.45%-5.88%) up to age 70 years, which represents an 8.6-fold increase (95% CI, 4.7-15.7) compared with the general population.
Conclusions Among 147 families with germline MMR gene mutations, the risk of pancreatic cancer was increased compared with the US population. Individuals with MMR gene mutations and a family history of pancreatic cancer are appropriate to include in studies to further define the risk of premalignant and malignant pancreatic neoplasms and potential benefits and limitations of surveillance.
Author Affiliations: Department of Internal Medicine, Brigham and Women's Hospital, Boston, Massachusetts (Drs Kastrinos, Stoffel, and Syngal); Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York (Dr Kastrinos); Departments of Biostatistics (Dr Mukherjee, Ms Tayob, and Mr Wang), Internal Medicine (Dr Gruber and Ms Raymond), and Epidemiology and Human Genetics (Dr Gruber), University of Michigan School of Public Health, Ann Arbor; and Population Sciences Division, Dana-Farber Cancer Institute, Boston, Massachusetts (Drs Sparr, Bandipalliam, Stoffel, and Syngal). Dr Kastrinos is now with Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Pancreatic Cancer and Gene Mutations for Lynch Syndrome
JWatch Gastroenterology 2009;2009:3-3.
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