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INEFFECTIVENESS OF LARGE DOSES IN THE PROPHYLAXIS OF OTITIS MEDIA COMPLICATING SCARLET FEVER

W. D. SUTLIFF, M.D.; EDWIN H. PLACE, M.D.; SAMUEL H. SEGOOL, M.D.

J Am Med Assoc. 1933;100(10):725-728.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The frequency with which localized purulent infections appear on the mucous membranes of animals and of men deprived of vitamin A has led to the view that an adequate supply of this vitamin may be essential for the maintenance of resistance to infection. It is logical to inquire whether certain purulent complications of the acute infectious diseases of childhood may not be prevented by supplying large amounts of vitamin A. An approach to an answer for this question has been made in the work to be reported. The otitis media following scarlet fever was chosen as the most suitable purulent infection for observation because of the following reasons: It develops at a site commonly infected in vitamin A deficient animals; it is relatively simple to diagnose; it occurs with considerable frequency and regularity; and it usually appears in the second, third and even fourth week of the disease, thus giving . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Thorndike Memorial Laboratory, Second and Fourth medical services (Harvard) of the Boston City Hospital and the Department of Medicine of the Harvard Medical School, and the South Department (for Infectious Diseases) of the Boston City Hospital.

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