This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

CLINICAL LECTURE AT ST. LOUIS SESSION

JOSEPH C. EDWARDS, M.D.; CHARLES L. HOAGLAND, M.D.; LAWRENCE D. THOMPSON, M.D.

J Am Med Assoc. 1939;113(21):1876-1880.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The application of the intracutaneous test with type specific pneumococcic polysaccharide as a guide in serum therapy rests on a basis as sound theoretically as that of the Schick test in the measurement of dermal resistance to diphtheria toxin. In the case of the pneumococcus polysaccharide a positive reaction indicates resistance to the pneumococcus, while in the Schick test a positive reaction is indicative of a lack of such resistance. In either case, however, dermal reactivity is used as a criterion of the immune status of the whole organism.

That pneumococci are not alike was an observation made in 1897 by Bezançon and Griffon,¹ who reported serologic differences among morphologically indistinguishable pneumococci. Briefly, the intact pneumococcus cell may be considered to exist as a body, or soma, of bacterial protein, surrounded by a discrete capsule consisting of a carbohydrate substance of relatively complex structure. When released from the intact . . . [Full Text PDF of this Article]

Author Affiliations
ST. LOUIS

From the Department of Internal Medicine, Washington University School of Medicine.

Footnotes
The work was made possible by grants to the Washington University School of Medicine from Eli Lilly & Co., Indianapolis.

Read in the General Scientific Meetings at the Ninetieth Annual Session of the American Medical Association, St. Louis, May 15, 1939.

The visiting and resident staffs and the laboratory personnel of St. Louis City Hospital, Barnes Hospital, St. Louis County Hospital, Jewish Hospital, St. Luke's Hospital and St. Mary's Hospital and the Department of Health of the City of St. Louis cooperated in this study. Eli Lilly & Co. supplied antipneumococcus rabbit serum and certain of the pneumococcus cultures from which Dr. C. L. Hoagland extracted the polysaccharides.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?