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BACITRACIN THERAPYThe First Hundred Cases of Surgical Infections Treated Locally with the Antibiotic
FRANK L. MELENEY, M.D.;
BALBINA JOHNSON, B.A.
J Am Med Assoc. 1947;133(10):675-680.
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In May 1943, while searching for evidence of bacterial antagonism in the bacterial mixtures to be found in badly contaminated accidental wounds, we discovered an aerobic gram-positive spore-forming bacillus which produced, in ordinary culture mediums, a powerful antibiotic agent with a wide spectrum of antibacterial activity. When it was found that the active principle was present in the filtrate of the bacterial culture and was nontoxic for laboratory animals, studies were begun on its concentration and purification for the purpose of applying it to the treatment of human infections.
The organism was found in the debrided tissue removed from a compound fracture of the tibia in a 7 year old girl by the name of Margaret Tracey. In her honor the new antibiotic has been named "bacitracin." The crude filtrate was found to inhibit the growth of hemolytic streptococci in the test tube and on blood agar plates. It was
. . . [Full Text PDF of this Article]
Author Affiliations
New York
From the Department of Surgery, Columbia University College of Physicians and Surgeons, and the Presbyterian Hospital.
Footnotes
The work described in this paper was done under a contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and the Columbia University College of Physicians and Surgeons and since Jan. 1, 1946 under a contract between the Office of the Surgeon General of the United States Army and Columbia University.
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