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J. WILLIAM CROSSON, M.D.; WILLIAM P. BOGER, M.D.; CHRISTOPHER C. SHAW, M.D.; A. KATHRINE MILLER, Ph.D.

J Am Med Assoc. 1947;134(18):1528-1532.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A new drug, caronamide,¹ when given orally to patients receiving penicillin produces a physiologic and reversible inhibition of the excretion of this antibiotic, which results in elevation of the concentration of penicillin in the plasma.

The primary objective of penicillin therapy is the maintenance of therapeutic concentrations of the antibiotic in the body tissues, but there appears to be no general agreement concerning therapeutic concentrations. Nor has it yet been made clear whether the maintenance of a constant level of penicillin plasma concentration is more desirable than the attainment of intermittent and temporary high levels. There does appear to be general agreement, however, that the attainment of high concentrations of penicillin is desirable.

It is difficult to attain elevated concentrations because of the rapidity with which penicillin is absorbed from the site of injection and excreted by the kidneys. Efforts have been made to maintain plasma concentrations of the . . . [Full Text PDF of this Article]

Author Affiliations
Philadelphia

Footnotes
The work herein reported was made possible by the cooperation of Garfield C. Duncan, M.D., Director of the Division of Medicine, Pennsylvania Hospital, who granted permission for the study of patients on the medical wards.

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