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CHARLES A. JANEWAY, M.D.

J Am Med Assoc. 1948;138(12):859-865.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Physiologic reasoning underlies sound practice in all fields of medicine today. But physiology, in turn, is dependent on chemistry for insight into the fundamental nature of the phenomena of health and disease. The work of a distinguished company of clinicians and medical scientists over a long period of years has evolved our present state of knowledge of the multiple functions of the blood and of their dependence on the molecular properties of the specific proteins by which they are mediated.

The development of blood derivatives stems logically from this concept that each function of the blood is due to one or more specific components. Great progress has been made in the decade since plasma first came into general clinical use as a derivative of blood in which its osmotic and certain of its nutritional properties could be preserved for use when separated from the more labile cells. Chemical and physical . . . [Full Text PDF of this Article]

Author Affiliations
Boston

From the Department of Pediatrics, Harvard Medical School and the Children's Medical Center, Boston.

Footnotes
Read in the General Scientific Meetings at the Ninety-Seventh Annual Session of the American Medical Association, Chicago, June 22, 1948.

This paper is number 74 in the series "Studies on the Plasma Proteins" from the Harvard Medical School, Boston, on products developed by the Department of Physical Chemistry from blood collected by the American Red Cross.

This work was originally supported by grants from the Rockefeller Foundation and from funds of Harvard University. It was aided early in 1941 by grants from the Committee on Medicine of the National Research Council, which included a grant from the American College of Physicians. From August 1941 to July 1946, it was carried out under contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and Harvard University. Since then it has been aided by a grant, recommended by the Panel of Hematology of the National Institute of Health, from the United States Public Health Service.

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