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NUTRITIONAL NEEDS IN ILLNESS AND DISEASE
GEORGE V. MANN, Sc.D., M.D.;
FREDRICK J. STARE, Ph.D., M.D.
J Am Med Assoc. 1950;142(6):409-419.
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Physicians are puzzled by the inability of their colleagues who work in investigative nutrition to supply them with the simple accurate statements of the daily requirements of the essential nutrients of a healthy human being. To the uninitiated it would seem a straightforward request of easy solution. However, the elusive mechanisms by which many of the essential nutrients function, coupled with a paucity of biochemical technics by which specific deficiencies can be accurately detected, have limited these answers to approximations.
In laboratory animals, when dietary factors can be rigorously controlled and when the use of large numbers of subjects allow statistically sound conclusions, the requirements are reasonably well established for at least a few species. The nutritional requirements of the rat, for example, are known fairly well, but this achievement has required the concerted efforts of hundreds of workers over a period of decades.
When one considers the abnormal, that
. . . [Full Text PDF of this Article]
Author Affiliations
Boston
From the Department of Nutrition, Harvard School of Public Health, Department of Biological Chemistry, Harvard Medical School, and the Medical Clinic, Peter Bent Brigham Hospital, Boston.
Footnotes
The authors wish to recognize grants-in-aid from the American Meat Institute, Chicago; Milbank Memorial Fund, New York; The Nutrition Foundation, Inc., New York; Swift & Company, Chicago, and the Upjohn Company, Kalamazoo, Mich. during the preparation of this review article.
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