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WITH INCREASED POTASSIUM FOR ROUTINE FLUID AND ELECTROLYTE REPLACEMENT

Charles L. Fox, Jr., M.D.; James M. Winfield, M.D.; Lawrence B. Slobody, M.D.; Charles M. Swindler, M.D.; John K. Lattimer, M.D.

J Am Med Assoc. 1952;148(10):827-833.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Recent studies have emphasized the desirability of maintaining normal levels of electrolytes and water in plasma and tissue cells. This is difficult to accomplish because the electrolyte composition of the primary replacement solutions generally available for parenteral therapy is significantly different from normal plasma. For example, 0.9% sodium chloride solution contains too much chloride but no bicarbonate and no potassium.

Attempts were made, therefore, to devise a water solution of plasma electrolytes to correct most anomalies. Animal experiments were conducted to obtain the first approximations, and then the proposed solution was subjected to clinical trial. The results to date have been sufficiently encouraging to warrant this report of our observations.

ANIMAL EXPERIMENTS

Hemorrhage was investigated first because of its ubiquity and importance in medicine and surgery and its reproducibility in dogs. Massive volumes of blood were removed from unanesthetized dogs and concurrently replaced with an electrolyte solution.¹ During and after the . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Departments of Bacteriology, Orthopedics, and Urology, College of Physicians and Surgeons, Columbia University, and the Departments of Surgery and Pediatrics, New York Medical College, Flower and Fifth Avenue Hospitals.

Footnotes
Aided in part by a grant from the Division of Research Grants and Fellowships, National Institutes of Health.

The balanced electrolyte solution was prepared by the Research Division of the Cutter Laboratories (Dr. Walter E. Ward, Medical Director) in accordance with our formula for experimental study and clinical trials.

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