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H. Shwachman, M.D.; B. K. Silverman, M.D.; P. R. Patterson, M.D.; L. J. Zheutlin, M.D.

J Am Med Assoc. 1952;149(12):1101-1108.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The beneficial effects of aureomycin in the management of patients with pancreatic fibrosis (mucoviscidosis) have been demonstrated.¹ An extension of observations begun three years ago, and including over 100 patients, shows a favorable response in over 90%. Anticipation of the appearance of refractoriness to aureomycin and the poor response of the occasional patient to aureomycin suggested the use of terramycin.² The present report is an evaluation of terramycin in the treatment of 49 patients with pancreatic fibrosis. All patients, with two exceptions (the patients in cases 2 and 3), had pulmonary infections of varying severity. A brief note concerning the efficacy of terramycin has been made.³ A full description of this disease is given elsewhere.⁴ The main clinical features drawing attention to this condition in early infancy are hunger, with failure to gain weight on an adequate caloric intake; the passage of large, foul, and frequent . . . [Full Text PDF of this Article]

Author Affiliations
Boston

From the Children's Medical Center, Boston, Division of Laboratories and Research, and Department of Pediatrics, Harvard Medical School.; Assistant Professor of Pediatrics, Harvard Medical School, Chief, Division of Clinical Laboratories, Children's Hospital (Dr. Shwachman); House Officer, Division of Laboratories, Children's Hospital (Dr. Silverman); Instructor in Pediatrics, Harvard Medical School (Dr. Patterson); and Research Fellow, Division of Laboratories and Research, Children's Hospital (Dr. Zheutlin).

Footnotes
The terramycin used in this study was supplied by Dr. Gladys L. Hobby and Dr. W. Alan Wright of the Chas. Pfizer & Co., Inc., Brooklyn.

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