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Some Clinical and Climatological Aspects Part II

Jerome W. Conn, MD

JAMA. 1963;183(10):871-878.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

STUDIES upon the mechanism by which normal¹ men acclimatize to heat, carried out in our laboratory between 1943 and 1946, gave information which was responsible for the recognition of primary aldosteronism as a clinical entity.

This included evidence that:

1. In the process of heat adaptation an endogenous desoxycorticosterone-like steroid is produced in large amounts as reflected in decreasing concentrations of sodium in thermal sweat. Administered desoxycorticosterone produced the same effects.
   
2. Increased steroidal activity of this type continued in the absence of evidence of increased activity of the adrenal cortex in other respects.
   
3. The ability of the acclimatizing man to maneuver himself into a condition of positive sodium balance, despite large sweat volumes, was accomplished by an integrated response of the kidney and sweat glands with respect to salt conservation, and that this was mediated by increased activity of the endogenous desoxycorticosteronelike steroid.
   
4. Renal escape from
   

Author Affiliations
Ann Arbor, Mich.

From the Department of Internal Medicine, The University of Michigan Medical Center. Professor of Internal Medicine and Director of the Division of Endocrinology and Metabolism and the Metabolism Research Unit.

Footnotes
Presented as the Gordon Wilson Lecture of the American Clinical and Climatological Association at French Lick, Ind., Oct 26, 1962.

Part I was published in last week's issue.

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