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Joseph F. Fraumeni, Jr., MD; Fred Ederer, MA; Robert W. Miller, MD, DrPH

JAMA. 1963;185(9):713-718.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE DISCOVERY that simian virus 40 (SV40) is oncogenic for certain newborn laboratory animals has raised the question of its carcinogenicity in man, particularly since this agent has been found in poliomyelitis and adenovirus vaccines. It is estimated that live SV40 has been injected into and ingested by hundreds of thousands, if not millions, of vaccines.¹ Although clinical disease has not been reported, SV40 has low infectivity in man when administered by mouth with attenuated poliovirus vaccine¹ and by the respiratory route.² From the evidence presently available, however, it appears that the largest source of potential human infectivity by SV40 in the US was formalinized poliomyelitis vaccine containing the simian agent administered subcutaneously.³ The purpose of this report is to present a brief review of the literature and an epidemiologic study bearing on this problem.

Review of Literature

In 1960 Sweet and Hilleman⁴ reported the . . . [Full Text PDF of this Article]

Author Affiliations
Bethesda, Md.

Medical Officer (Dr. Fraumeni) and Chief (Dr. Miller), Epidemiology Branch, and Head, Biometrics Analysis Section, Biometry Branch (Mr. Ederer), National Cancer Institute, National Institutes of Health, US Public Health Service.

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