This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (33)  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

James O. Davis, MD

JAMA. 1964;188(12):1062-1068.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ALDOSTERONE AND ANGIOTENSIN II are Ltwo of the important hormones associated with the formation of edema. It also seems likely that both hormones are involved in certain types of hypertensive disease. Aldosterone, a complex steroid, is the naturally occurring sodium-retaining hormone secreted by the adrenal cortex. Angiotensin II is a peptide composed of eight amino acids and is formed by enzymatic reactions which take place in blood. Renin, an enzyme secreted by the kidney, initiates the reactions leading to the formation of angiotensin II.

In 1960, two new findings focused attention on the relationship of the renin-angiotensin system to aldosterone secretion. First, it was discovered that an aldosterone-stimulating hormone is secreted by the kidney,^1-3 and, second, synthetic angiotensin II was found to stimulate aldosteron secretion in man.^4-5 These experimental results were the culmination of a series of researches following the isolation and identification of aldosterone in 1953. These . . . [Full Text PDF of this Article]

Author Affiliations
Bethesda, Md

From the Section on Experimental Cardiovascular Disease, Laboratory of Kidney and Electrolyte Metabolism, National Heart Institute.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?