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JAMA. 1964;190(12):1064.

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The application of ointments containing salicylic acid to dermatoses associated with hyperkeratosis has long been a standard method of treatment. Intoxication with salicylic acid by percutaneous penetration is not a frequent complication, or perhaps its occurrence has not always been recognized. The December issue of the Archives of Dermatology¹ presents three instances of nonfatal intoxication by percutaneous penetration of salicylic acid in adults with extensive psoriasis. The patients were treated with an ointment containing 3% or 6% salicylic acid, which was applied six times a day. Between the second and fourth day symptoms of salicylism developed in all three patients. The outstanding symptoms were nausea, dyspnea, decreased ability to hear, confusion and hallucinations. The levels of salicylic acid in the serum ranged from 46 to 64 mg/100 ml. Within one day after discontinuing the application of the ointment, the symptoms had largely disappeared. Also, the levels of salicylic acid in . . . [Full Text PDF of this Article]

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