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Alvin S. Zelickson, MD

JAMA. 1965;194(6):670-672.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SINCE THE first reports detailing a new syndrome of dermatologic and ophthalmologic changes in patients receiving prolonged and high doses of chlorpromazine,^1,2 there have been many subsequent papers dealing with the subject.^3-10 Many of the reports have been concerned with the development of slate-blue skin pigmentation in these patients, and the general consensus has been that it is the result of a melanin or melaninlike substance.

As previously reported, this syndrome is characterized by discoloration of the exposed areas of the body. The pigmentation may range in degree from a slight darkening of the skin to a definite slate-gray or blue color. Histologic examination has revealed a pigment chiefly in the corium, which has been suggested to be melanin. Ocular changes have been noted with and without overt skin pigmentation. The eye changes consist of a deposition of fine particles in the anterior capsular and subcapsular portion of . . . [Full Text PDF of this Article]

Author Affiliations
From the Division of Dermatology, University of Minnesota Medical School, Minneapolis.

Footnotes
Reprint requests to University of Minnesota Medical School, Minneapolis 55455.

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