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Preliminary Report

Warren Winkelstein, Jr., MD, MPH; Seymour Kantor; Michel Ibrahim, MD, PhD; David L. Sackett, MD

JAMA. 1966;195(10):848-850.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The familial aggregation of blood pressure levels has been repeatedly documented and variously interpreted as supporting either a polygenic^1,2 or a single-gene^3,4 mechanism for blood pressure regulation. Only a few recent studies have mentioned the possibility that familial aggregation of blood pressure levels may be a manifestation of common environmental influences. Of these, three have included data from husbands and wives, who serve as controls within kinships since, in western society, consanguinous marriages are quite rare. From two studies^5,6 there was no evidence that husbands and wives acquired similar blood pressure levels over time, while from the third⁷ evidence of spouse aggregation was reported. Given the occurrence of blood pressure aggregation among blood kin, the demonstration of spouse aggregation would support an environmental explanation of familial aggregation if it were not present early in marriage but developed later.

Methods and Materials

Familial aggregation of blood pressure . . . [Full Text PDF of this Article]

Author Affiliations
From the departments of preventive medicine (Drs. Winkelstein, Ibrahim, Sackett, and Mr. Kantor) and medicine (Dr. Sackett), State University of New York at Buffalo School of Medicine.

Footnotes
Reprint requests to 2211 Main St, Buffalo, NY 14214 (Dr. Winkelstein).

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