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Balanced Salt Solution in the Treatment of Hemorrhagic ShockStudies in Dogs
Robert N. McClelland, MD;
G. Tom Shires, MD;
Charles R. Baxter, MD;
C. Dale Coln, MD;
James Carrico, MD
JAMA. 1967;199(11):830-834.
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Previous studies show a decreased mortality from hemorrhagic shock when Ringer's lactate solution is given intravenously in addition to replacement of shed blood. The improved survival rate seems related to restoration of a disproportionate extracellular fluid reduction occurring with hemorrhagic shock.1
The objectives of this study were (1) to define some of the physiological effects of the treatment of hemorrhagic shock with blood replacement and Ringer's lactate solution, and (2) to investigate the theoretical objection that Ringer's lactate solution may aggravate lactic acidosis when used to treat shock.
Materials and Methods
Twenty-four previously splenectomized mongrel dogs ranging in weight from 17 to 26 kg (38 to 58 lb) were anesthetized with pentobarbital given intravenously and breathing was controlled by a respirator using room air. Bilateral femoral artery and vein and external jugular vein cannulizations were done. Mean femoral arterial blood pressure and pulse rate were monitored continuously with a
. . . [Full Text PDF of this Article]
Author Affiliations
From the Department of Surgery, University of Texas, South-western Medical School, Dallas.
Footnotes
Read before the session on cardiovascular subjects of the Sixth Multidiscipline Research Forum during the 115th annual convention of the American Medical Association, Chicago, June 30, 1966.
Reprint requests to 5323 Harry Hines Blvd, Dallas 75235 (Dr. McClelland).
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