This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Bernard B. Brodie, PhD

JAMA. 1967;202(7):600-609.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

There are two facets to the problem of the biochemical and physical aspects of drug actions, the influence of drugs on the body and the influence of the body on drugs. In the past, pharmacology has emphasized the action of drugs on the living organism. But to be effective, a substance must have characteristics that allow it to reach its site of action in adequate concentration and to remain there for a suitable period of time. For this reason, we become concerned with the physical and biochemical factors that determine the duration of drug action.

About 25 years ago, when I first became interested in the fate of drugs, I felt like the bat in Aesop's fable. Journals of pharmacology showed considerable reluctance in associating themselves with this "biochemical" topic, while biochemical journals refused these "drug" papers outright. But over the years pharmacology has broadened and these sort of studies . . . [Full Text PDF of this Article]

Author Affiliations
From the Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, Md.

Footnotes
Presented as a 1967 Albert Lasker Basic Research Award Lecture at the New York University Medical Center, New York, Nov 9, 1967.

Reprint requests to Laboratory of Chemical Pharmacology, National Heart Institute, Bethesda, Md 20014.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?