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Localized Renal Adenocarcinoma

Philip Rubin, MD

JAMA. 1968;204(3):219-220.

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The misnomer of "hypernephroma" for renal carcinoma originated historically and identifies the controversial and confusing nature of this tumor. The earliest literature describes this tumor as a medullary sarcoma of the kidney¹ and so-called lipoma.² Renal carcinoma was thought to arise from adrenal rests in the kidney, and its early recognition in the upper pole of the kidney led to the name of hypernephroma. The proper nomenclature would be "adenocarcinoma of the kidney," but a variety of terms have been introduced because of differences in microscopic appearance: (1) cell type related to the clearness or granularity of the cytoplasm, ie, clear or granular cells; (2) cell morphology, ie, its state of differentiation or anaplasia; and (3) cell arrangement, ie, medullary, tubular, cystic, papillary. However, the differences in prognosis ascribed to these histologic appearances and various authors' attempts to relate the clinical course to a specific cell type have . . . [Full Text PDF of this Article]

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