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Two Simple Methods for Rapid Detection of Malignant Cells in Spinal Fluid

Roland T. Skeel, MD; Ronald A. Yankee, MD; Edward S. Henderson, MD

JAMA. 1968;205(12):863-865.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The syndrome of meningeal leukemia is one of the major complications of acute leukemia.^1,2 The manifestations of the clinical syndrome include headache, nausea, vomiting, eye signs, cranial nerve palsies, and lethargy, and may be associated with increased intracranial pressure. The observation that cerebrospinal fluid (CSF) pleocytosis is almost always associated with the clinical syndrome has shifted the emphasis in the criteria for diagnosis from dependence on clinical signs and symptoms to a greater reliance on laboratory findings.^3,4 More recent studies further demonstrate that the CSF pleocytosis may precede the symptoms. In the review of cases reported by Nies et al,³ the diagnosis of meningeal leukemia was said to be established by the presence of ten or more mononuclear cells per cubic millimeter in the spinal fluid. Judged by this criterion, of 38 cases of meningeal leukemia, 14 had no presenting signs or symptoms at the time of . . . [Full Text PDF of this Article]

Author Affiliations
From the National Cancer Institute, Bethesda, Md.

Footnotes
Reprint requests to Room 2B51, Bldg 10, National Cancer Institute, National Institutes of Health, Bethesda, Md 20014 (Dr. Skeel).

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