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1-Antitrypsin Deficiency and Emphysema

Jack Lieberman, MD; Charles Mittman, MD
City of Hope Medical Center Duarte, Calif

JAMA. 1970;211(10):1701.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Dr. Resnick and his colleagues "have been unable to find a single homozygous deficient subject, but found a number of TICs below 0.4, ie, in the heterozygous range." Our communications^1,2 and most others state that TIC values below 0.4 are in the homozygous range, not heterozygous. Normal TIC values fall above 0.85 units; heterozygates between 0.4 and 0.85 units. The finding of a number of homozygates in their group of miners is of great interest.

It is possible that Resnick et al were unable to detect a bimodal distribution of TIC values in their study of a relatively healthy population because the miners studied had no definitive chest disease other than a complaint of shortness of breath. We were not able to demonstrate a bimodal distribution in our normal control populations, but 4.7% of the subjects tested, comprising the lowermost tail of the distribution curve, were . . . [Full Text PDF of this Article]

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