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JAMA. 1970;211(13):2150.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Uncertainty persists about the etiology of vascular disease in diabetes mellitus. Its wide prevalence in this genetically determined disorder has suggested that the tendency toward an unhealthy vasculature may be connected somehow with the gene or genes responsible for diabetes itself. On the other hand, there are good, though not compelling, reasons for believing that poor control of diabetes favors, if it does not cause, both macroangiopathy and microangiopathy. At least two kinds of evidence militate against a genetic influence as being the sole offending agent. First, typical small-vessel disease has been found in a sizable number of patients with diabetes caused by hemochromatosis, chronic pancreatitis, or pancreatectomy in the absence of a diabetic family history. Second, similar lesions have been described in animals with long-term, poorly controlled, experimental diabetes.

If the diabetic state, with or without genetic predilection, induces vascular abnormalities, what aspects of that state could be incriminated? . . . [Full Text PDF of this Article]

Footnotes
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