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Joel S. Steinberg, MD; David A. Rosin, MD
Case Western Reserve University Cleveland

JAMA. 1970;211(6):1012.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Lithium salts were introduced as pharmacologically effective agents in the treatment of affective psychoses in 1949 by Cade.¹ Many reporting attest to the efficacy of lithium salts in these disorders.^1-11 Cade also proposed that the claiming effects of certain medicinal springs might lie in the concentration of lithium ions in the water. To our knowledge, no attempt has been published testing the above hypothesis. Cade himself has not studied the matter further (personal communication, 1967).

Some mineral waters have been found to have lithium ion concentrations approaching 1 mEq/liter,¹² and some naturally occurring brines have even higher concentrations.¹²

Commercially significant deposits of lithium are by no means ubiquitous. In North America, there are four such areas known. They are in the Black Hills of South Dakota, Kings Mountain area of North Carolina, Val d'Or region of Quebec, and in the brines of Searles . . . [Full Text PDF of this Article]

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