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Jerome Motto, MD
San Francisco

JAMA. 1970;211(7):1188-1189.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

I welcome the comments of my colleagues but regret that they offer no specific data in their letter. The assertion that current data on antidepressants demonstrate their efficacy is open to question.

Cole¹ states that after seven years of experience with antidepressants "their place in the physicians' armamentarium is far from clear" and that "the differences between the efficacy of the drug and a placebo have not been as great as one might wish." Klein and Davis³ list 25 controlled comparisons of imipramine and placebo imipramine is found superior in 7, questionable in 13, and equal to placebo in 5. Kalinowski and Hippius⁴ caution that while published figures reflect the optimal potential of these drugs, "in actual practice other considerations often arise," that4 "agitated depressions respond poorly or not at all," that those depressions with "much neurotic symptomatology or hypochrondriasis give poor results," and . . . [Full Text PDF of this Article]

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