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JAMA. 1970;211(8):1367-1368.

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The ban on the general use of cyclamates as individual sweetening agents and in food products has raised two major questions: Is there a risk associated with their continued use; and in the interest of the diabetic patient, what special dietary foods containing cyclamates will be permitted to be marketed?

It is impossible to assess the carcinogenic hazard to human beings from the information currently available from studies on animals. The research which prompted the action to greatly restrict the availability of cyclamates was a two-year toxicologic study with rats fed three levels of a 10:1 cyclamatesaccharin mixture. Rats fed 2,500 mg/kg of body weight developed malignant bladder tumors. No tumors were found in animals fed 500 or 1,200 mg/kg of body weight. The secretary of Health, Education, and Welfare, when made aware of this information, had no choice under the provisions of the so-called Delaney clause of the Food, . . . [Full Text PDF of this Article]

Footnotes
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