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Donald F. Klein, MD
Glen Oaks, NY

John M. Davis, MD
Bethesda, Md

JAMA. 1970;212(11):1962-1963.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

The exchange of letters by Callaway et all with Motto (211:1188, 1970) concerning the drug treatment of depression requires some comment.

Callaway et al criticize Motto for stating that he is "unimpressed by what are called antidepressant drugs," that he could not find reasonable evidence of antidepressive effects, and had "yet to see a welldesigned and executed clinical investigation that demonstrates more than a mild tranquilizing benefit" from the tricyclic antidepressants. He then recommends the use of dextroamphetamine.

Callaway et al point out that there has been ample demonstration of the efficacy of antidepressants and that the evidence is plentiful and accessible. They further disagree with Motto's view that amphetamines are very effective, and in fact state that there is available "literature as to their demonstrated ineffectiveness."

In rebuttal Motto first quotes Cole¹ as stating that the place of antidepressants in the physician's armamentarium is . . . [Full Text PDF of this Article]

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