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Jo Leigh Simpson, MD; James German, MD
New York

JAMA. 1970;212(13):2264-2265.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

Familial occurrence of a given disorder may provide the first indication that genetic factors are of importance in its etiology. Our purposes here are (1) to provide the references to previously published reports concerning the uropathies and anomalies of the ureters and bladder and (2) to record some personal observations of familial urinary tract anomalies, thus, raising a question concerning the possible importance of heredity in this group of disorders.

Hydronephrosis without hydroureters, suggesting uretero-pelvic junction obstruction, has been observed in sibs¹ and in two^2,3 and three^4,5 generations of families; in two^1,3 of these families aberrant renal vessels were described. Hydronephrosis accompanied by hydroureters,⁶ ureterocele,⁷ bladder neck obstruction,⁸ or posterior urethral valves^9,10 has occurred in sibs or twins. Familial occurrence of ectopic ureteral insertion¹¹ and duplication of the collecting system^2,12-15 have also been observed. Lenz² refers . . . [Full Text PDF of this Article]

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