This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Ramon B. Jenkins, MD; Robert H. Groh, MD
Washington, DC

JAMA. 1970;212(13):2265.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

The letter of Drs. Tobias and Merlis (211:1857,1970) reported their experience of the aggravation of psychiatric symptoms following the administration of levodopa to schizophrenic patients suffering from drug-induced parkinsonism, and the appearance of psychiatric symptoms in patients with Parkinson's disease.

The production of psychotic and other mental symptoms in nonschizophrenic patients has been reported by others.^1-3 Bunney and coworkers⁴ reported an apparent antidepressant action of levodopa but other authors have reported the appearance of severe depression in some patients.^3,5 A number of drugs and foods are reputed to antagonize the therapeutic effects of levodopa. They include monoamine oxidase inhibitors and psychic energizers, reserpine, phenothiazines, antiemetics, tranquillizers, and alpha methyldopa,⁶ cheese, chocolate, and red wine,⁷ butyrophenones, and pyridoxine.⁸

Because of the lack of information on psychic features given in most articles, and because the warnings against certain other drugs appears to be . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?