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Ambiguous External Genitalia in the Newborn and Prepubescent Child
W. Paul Dmowski, MD;
R. B. Greenblatt, MD
JAMA. 1970;212(2):308-311.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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The sexual makeup of an individual consists of several components both physical and psychological in nature. In the normal being, male or female, all characteristics are expected to be of one gender, harmonious with the chromosomal pattern established in the zygote at the time of fertilization. However, the bisexual potential inherent in everyone may result in the emergence of abnormalities both physical and psychological. Aberrations at any of the stages of development may thus result in the incomplete or faulty differentiation of the particular component and sexual ambiguity.
Ambiguous external genitalia is not a syndrome per se, but manifestation of abnormal development common to many disorders. The occurrence is approximately one in every 30,000 newborns. Despite its relative rarity, this condition carries several serious implications and requires careful evaluation when observed neonatally or in the prepubescent child.
Embryogenesis of External Genitalia
External genitalia originate from the same primordial structures in
. . . [Full Text PDF of this Article]
Author Affiliations
From the Medical College of Georgia, Augusta. Dr. Dmowski holds a research fellowship from the Population Council.
Footnotes
Reprint requests to Medical College of Georgia, Gwinette Street, Augusta 30902 (Dr. Greenblatt).
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