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JAMA. 1970;212(3):482.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor:—

Glucagon was discovered in 1923 as a contaminant of early insulin preparations. Since that time a welter of observations and facts have been accumulated on which the current day assessment of glucagon's place in clinical medicine must be made.

A recent study by Kock et al¹ has prompted us to apply their findings in an attempt to increase portal vein blood flow following hepatic artery ligation for metastatic cancer to the liver.

Kock et al demonstrated in dogs by use of the electromagnetic flow meter that following the intravenous administration of 10µg/kg of glucagon a 90% maximal increase in portal vein flow occurred associated with a 70% increase in portal pressure. The effect was maximal in approximately 5 minutes and then decreased appoximating normal flow and pressure readings at 35 minutes.

It is known that the portal vein in the human supplies approximately 75% of the . . . [Full Text PDF of this Article]

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