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Bruce Ettinger, MD; Felix O. Kolb, MD
University of California Medical Center San Francisco

JAMA. 1970;212(4):627.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.—

In a previous PRELIMINARY COMMUNICATION (205: 846,1968) from this laboratory, Fariss and Kolb reported that chlordiazepoxide hydrochloride (Librium) appeared to have a crystalretarding effect in six patients with cystinuria. These outpatient studies were carried out on spot urine specimens using a qualitative evaluation of crystalluria. In a subsequent double-blind study of 12 cystinuric patients, using quantitative measurements of cystine excretion and also a method to quantitate cystine crystal formation at various concentrations and temperatures, chlordiazepoxide did not affect (1) the appearance and degree of spontaneous crystalluria, (2) the daily excretion of cystine, (3) the solubility of cystine in urine, or (4) the rate of crystallization of cystine from supersaturated urine specimens. These data have been submitted for publication.

There appears to be a factor retarding crystal formation in cystinuric patients which is more pronounced in concentrated than in dilute urine. This may account for the intermittent occurrence . . . [Full Text PDF of this Article]

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